Synergistic anti-tumor activity and mechanisms of total glycosides from Cimicifuga dahurica in combination with cisplatin

Zhang, Leilei; Si, Jianmin; Zhang, Lijing; Huo, Xiaowei; Lin, Li Fang; Li, Ruyi; Chen, Dan; Cao, Li

doi:10.1007/s11655-015-2108-3

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Limited information regarding the in vivo effects of actein on tumor growth, especially breast cancer, has ever been shown. Though the efficacies of extracts of other Cimicifuga species in tumor-bearing models were reported, the findings were controversy 20 21 22 23 24 . In the present study, the efficacies of actein on angiogenesis, breast tumor growth and metastasis in an immunocompetent mouse model were revealed for the first time.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the in vivo anti-tumor activities of extracts or active components from Cimicifuga species have been reported, such as extracts of C. racemosa in breast cancer rat model 20 , prostate cancer mouse model 21 and total glycosides from C. dahurica in hepatoma-bearing mice 22 23 . However, controversial findings were also observed in transgenic mice expressing c-erbB2, in which extract of C. racemosa increased metastatic mammary cancer 24 .…”

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confidence: 99%

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New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

Yue

Xie

Lee

et al. 2016

Sci Rep

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Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida (Chinese herb “shengma”) which could inhibit the growth of breast cancer cells. Nevertheless, the effect of actein on angiogenesis, which is an essential step for tumor growth and metastasis, has never been reported. Hence, this study aimed to investigate the in vitro and in vivo effects of actein on angiogenesis using human microvascular endothelial cells (HMEC-1), matrigel plug and tumor-bearing mouse models. Our results showed that actein significantly inhibited the proliferation, reduced the migration and motility of endothelial cells, and it could suppress the protein expressions of VEGFR1, pJNK and pERK, suggesting that JNK/ERK pathways were involved. In vivo results showed that oral administration of actein at 10 mg/kg for 7 days inhibited blood vessel formation in the growth factor-containing matrigel plugs. Oral actein treatments (10–15 mg/kg) for 28 days resulted in decreasing mouse 4T1 breast tumor sizes and metastasis to lungs and livers. The apparent reduced angiogenic proteins (CD34 and Factor VIII) expressions and down-regulated metastasis-related VEGFR1 and CXCR4 gene expressions were observed in breast tumors. Our novel findings provide insights into the use of actein for development of anti-angiogenic agents for breast cancer.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

Yue

Xie

Lee

et al. 2016

Sci Rep

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“…In addition, total glycosides of C. dahurica against hepatoma through inducing cycle arrest and apoptosis in HepG2 cells and inhibiting the implanted mouse H22 tumor growth dose-dependently [ 74 ]. It elevated the anti-hepatoma activity and also had the ability to inhibit the growth of human colon cancer cells when combined with cisplatin [ 75 ]. Actein and 26-deoxyactein performed significant anti-tumor activity in 12 human cancer cell lines with the IC 50 range of 12.29 ~ 88.39 µg/mL in vitro .…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma: a comprehensive review

Zhang,

Wei,

Jin

et al. 2024

Chin Med

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Cimicifugae Rhizoma, generally known as “Sheng Ma” in China, has great medicinal and dietary values. Cimicifugae Rhizoma is the dried rhizome of Cimicifuga foetida L., Cimicifuga dahurica (Turcz.) Maxim. and Cimicifuga heracleifolia Kom., which has been used to treat wind-heat headache, tooth pain, aphtha, sore throat, prolapse of anus and uterine prolapse in traditional Chinese medicine. This review systematically presents the traditional uses, phytochemistry, pharmacology, clinical studies, quality control and toxicity of Cimicifugae Rhizoma in order to propose scientific evidence for its rational utilization and product development. Herein, 348 compounds isolated or identified from the herb are summarized in this review, mainly including triterpenoid saponins, phenylpropanoids, chromones, alkaloids, terpenoids and flavonoids. The crude extracts and its constituents had various pharmacological properties such as anti-inflammatory, antitumor, antiviral, antioxidant, neuroprotective, anti-osteoporosis and relieving menopausal symptoms. The recent research progress of Cimicifugae Rhizoma in ethnopharmacology, phytochemistry and pharmacological effects demonstrates the effectiveness of its utilization and supplies valuable guidance for further research. This review will provide a basis for the future development and utilization of Cimicifugae Rhizoma.

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Anticancer Chemodiversity of Ranunculaceae Medicinal Plants

Hao¹

2019

Ranunculales Medicinal Plants

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Synergistic anti-tumor activity and mechanisms of total glycosides from Cimicifuga dahurica in combination with cisplatin

Abstract: TGCD enhanced the anticancer activity of CDDP in an additive-to-synergistic manner by activating multiple signaling pathways (including apoptosis). These fifi ndings suggest the potential benefifi t of combined treatment of the TGCD and CDDP against cancer of the colon and liver.

Cited by 4 publications

References 24 publications

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma: a comprehensive review

Anticancer Chemodiversity of Ranunculaceae Medicinal Plants

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