2020
DOI: 10.1080/14786419.2020.1736065
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Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke

Abstract: A new flavone, named hildeflavone (1) along with 7 other known flavonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPSstimulated PBMCs with the isolated flavonoids at a concentration of 100 µM signif… Show more

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Cited by 7 publications
(5 citation statements)
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“…Recent in vitro studies have described the anti-inflammatory effects of isoflavones on peripheral blood mononuclear cells stimulated with lipopolysaccharide, thereby reducing IL1-β, IL-2, IL-6, and TNF-α levels [89,90]. [80,91] Nevertheless, it must also be stressed that studies have been published showing no impact of this alternative approach on the immune systems of menopausal women.…”
Section: Isoflavones and Inflammation In Menopausal Womenmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent in vitro studies have described the anti-inflammatory effects of isoflavones on peripheral blood mononuclear cells stimulated with lipopolysaccharide, thereby reducing IL1-β, IL-2, IL-6, and TNF-α levels [89,90]. [80,91] Nevertheless, it must also be stressed that studies have been published showing no impact of this alternative approach on the immune systems of menopausal women.…”
Section: Isoflavones and Inflammation In Menopausal Womenmentioning
confidence: 99%
“…Recent in vitro studies have described the anti-inflammatory effects of isoflavones on peripheral blood mononuclear cells stimulated with lipopolysaccharide, thereby reducing IL1-β, IL-2, IL-6, and TNF-α levels [ 89 , 90 ].…”
Section: Isoflavones and Inflammation In Menopausal Womenmentioning
confidence: 99%
“…Flavonoids ( Figure 1 ) can modulate proliferation [ 5 , 39 , 41 , 42 , 43 , 44 ], invasion [ 45 , 46 ], and inflammatory signals through a variety of pathways associated with their qualities as antioxidants [ 24 , 47 ], estrogen agonists, or CYP1 (Cytochrome P450) inhibitors [ 39 ]. Flavonoids have also been found to influence inflammatory signaling via systems such as NF-кB (nuclear factor B), which regulates cell proliferation and survival [ 21 , 23 ].…”
Section: Flavonoid and Anti-cancer Effectmentioning
confidence: 99%
“…Flavones, flavanones, flavanols, flavonols, isoflavones, and anthocyanidins are the six subclasses of flavonoids [ 20 ]. According to a study, flavonoids have anti-inflammatory [ 21 ], antiviral [ 22 ], anti-allergic [ 23 ], antioxidant [ 24 ], and anti-tumor [ 25 ] properties. According to a study, flavonoids also inhibit tumor growth by causing death in cancer cells [ 26 ].…”
Section: Introductionmentioning
confidence: 99%
“…CFs are composed of two or more flavonoid ingredients, with many pharmacological activities including anticancer, antivirus, antioxidation, and immune-enhancing functions [11][12][13]. Furthermore, CFs have stronger radical scavenging capability and immune-modulating effect than single CHM flavonoids [14,15]. e limiting factors of the yield of flavonoids can be divided into quantitative variables (e.g., liquid-solid ratio, extraction temperature, and extraction duration) and qualitative variables (e.g., extraction mode).…”
Section: Introductionmentioning
confidence: 99%