Synergistic anti-inflammatory activities of a new flavone and other flavonoids from <i>Tephrosia hildebrandtii</i> vatke

Owor, Richard Oriko; Bedane, Kibrom Gebreheiwot; Openda, Yolande Ikala; Zühlke, Sebastian; Derese, Solomon; Ong’amo, George; Ndakala, Albert; Spiteller, Michael

doi:10.1080/14786419.2020.1736065

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Recent in vitro studies have described the anti-inflammatory effects of isoflavones on peripheral blood mononuclear cells stimulated with lipopolysaccharide, thereby reducing IL1-β, IL-2, IL-6, and TNF-α levels [89,90]. [80,91] Nevertheless, it must also be stressed that studies have been published showing no impact of this alternative approach on the immune systems of menopausal women.…”

Section: Isoflavones and Inflammation In Menopausal Womenmentioning

confidence: 99%

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Effects of Hormone Therapy and Flavonoids Capable on Reversal of Menopausal Immune Senescence

et al. 2021

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Menopause, probably the most important natural change in a woman’s life and a major component of female senescence, is characterized, inter alia, by cessation of ovarian estrogen and progesterone production, resulting in a gradual deterioration of the female immune system. Hormone replacement therapy (HRT) is used in postmenopausal women to relieve some of the peri- and postmenopausal symptoms, while there is also evidence that the therapy may additionally partially reverse menopausal immune senescence. Flavonoids, and especially isoflavones, are widely used for the treatment of menopausal symptoms, although it is not at present clear whether they can reverse or alleviate other menopausal changes. HRT reverses the menopausal CD4/CD8 ratio and also limits the general peri- and postmenopausal inflammatory state. Moreover, the increased levels of interleukins (IL)-1β, IL-6, and IL-8, as well as of tumor necrosis factor-α (TNF-α) are decreased after the initiation of HRT. However, some reports show no effect of HRT on IL-4, IL-10, and IL-12. It is thus evident that the molecular pathways connecting HRT and female immune senescence need to be clarified. Interestingly, recent studies have suggested that the anti-inflammatory properties of isoflavones possibly interact with inflammatory cytokines when applied in menopause treatments, thereby potentially reversing immune senescence. This narrative review presents the latest data on the effect of menopausal therapies, including administration of flavonoid-rich products, on age-associated immune senescence reversal with the aim of revealing possible directions for future research and treatment development.

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Section: Isoflavones and Inflammation In Menopausal Womenmentioning

confidence: 99%

Section: Isoflavones and Inflammation In Menopausal Womenmentioning

confidence: 99%

Effects of Hormone Therapy and Flavonoids Capable on Reversal of Menopausal Immune Senescence

et al. 2021

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“…Flavonoids ( Figure 1 ) can modulate proliferation [ 5 , 39 , 41 , 42 , 43 , 44 ], invasion [ 45 , 46 ], and inflammatory signals through a variety of pathways associated with their qualities as antioxidants [ 24 , 47 ], estrogen agonists, or CYP1 (Cytochrome P450) inhibitors [ 39 ]. Flavonoids have also been found to influence inflammatory signaling via systems such as NF-кB (nuclear factor B), which regulates cell proliferation and survival [ 21 , 23 ].…”

Section: Flavonoid and Anti-cancer Effectmentioning

confidence: 99%

“…Flavones, flavanones, flavanols, flavonols, isoflavones, and anthocyanidins are the six subclasses of flavonoids [ 20 ]. According to a study, flavonoids have anti-inflammatory [ 21 ], antiviral [ 22 ], anti-allergic [ 23 ], antioxidant [ 24 ], and anti-tumor [ 25 ] properties. According to a study, flavonoids also inhibit tumor growth by causing death in cancer cells [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Function and Application of Flavonoids in the Breast Cancer

Park

Kim

et al. 2022

IJMS

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Breast cancer is one of the top causes of death, particularly among women, and it affects many women. Cancer can also be caused by various factors, including acquiring genetic alteration. Doctors use radiation to detect and treat breast cancer. As a result, breast cancer becomes radiation-resistant, necessitating a new strategy for its treatment. The approach discovered by the researchers is a flavonoid, which is being researched to see if it might help treat radiation-resistant breast cancer more safely than an approved medicine already being used in the field. As a result, this study focuses on the role of flavonoids in breast cancer suppression, breast cancer gene anomalies, and the resulting apoptotic mechanism.

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“…CFs are composed of two or more flavonoid ingredients, with many pharmacological activities including anticancer, antivirus, antioxidation, and immune-enhancing functions [11][12][13]. Furthermore, CFs have stronger radical scavenging capability and immune-modulating effect than single CHM flavonoids [14,15]. e limiting factors of the yield of flavonoids can be divided into quantitative variables (e.g., liquid-solid ratio, extraction temperature, and extraction duration) and qualitative variables (e.g., extraction mode).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Extraction of Compound Flavonoids from Chinese Herbal Medicines Based on Quantification Theory and Evaluation of Their Antioxidant Activity

Yang

Cao

et al. 2022

Journal of Food Quality

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Plant-derived flavonoids have been attracting increasing research interest because of their multiple health promoting effects, where numerous investigations were carried out on the optimization of extraction and bioactivities. is study aims to optimize the extraction process of compound flavonoids (CFs) from Chinese herbal medicines and detect their antioxidant activity in vitro. CFs were extracted from the raw materials named "medicine food homology," composed of hawthorn, lotus leaf, tartary buckwheat, cassia seed, Lycium barbarum, and Poria cocos in a mass ratio of 4 : 2 : 2 : 1.5 : 1 : 1. L 9 (3 4 ) orthogonal design, level effect and engineering average estimation, and quantification theory were utilized to improve the extraction method of CFs, and the predictive model for CFs yield was constructed.e 2,2ʹ-diphenyl-1-picrylhydrazyl (DPPH), 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), hydroxyl radical scavenging rate, and reducing power of CFs were measured. e highest CFs yield was obtained under the following extraction condition: liquid-solid ratio of 35 : 1 mL/g, extraction temperature of 75 °C, extraction duration of 75 min, and extraction mode enzyme-assisted extraction. e forecasted yield was 37.62%. e result was accurate and the established prediction equation was reliable (R � 0.95). e antioxidant activity of CFs was significantly positively correlated with the concentration from 0.05 to 0.4 mg/mL. e DPPH, ABTS, hydroxyl radical scavenging abilities, and the reducing power of CFs were 81.82 ± 1.75%, 49.35 ± 0.09%, 89.78 ± 0.66%, and 0.232 ± 0.001 at the concentration of 0.4 mg/mL, respectively. CFs could be exploited as natural antioxidants in pharmaceuticals and functional foods.

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Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke

Cited by 7 publications

References 29 publications

Effects of Hormone Therapy and Flavonoids Capable on Reversal of Menopausal Immune Senescence

Effects of Hormone Therapy and Flavonoids Capable on Reversal of Menopausal Immune Senescence

Function and Application of Flavonoids in the Breast Cancer

Optimization of Extraction of Compound Flavonoids from Chinese Herbal Medicines Based on Quantification Theory and Evaluation of Their Antioxidant Activity

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