Synergistic and enhanced anticancer effect of a facile surface modified non-cytotoxic silver nanoparticle conjugated with gemcitabine in metastatic breast cancer cells

Karuppaiah, Arjunan; Karthik, S.; Selvaraj, Divakar; Ramasamy, Mohankandhasamy; Babu, Dinesh; Sankar, Veintramuthu

doi:10.1016/j.mtcomm.2019.100884

Cited by 19 publications

(14 citation statements)

References 52 publications

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“…The experimental results reported until recently are not enough to conclude with precision which are the effects and mechanisms of toxicity of AgNPs. However, toxicity is a limiting factor for its in vivo use [20,58,59].…”

Section: Biotoxicitymentioning

confidence: 99%

“…AgNPs were also exploited as nanocarriers of the anticancer drug gemcitabine in 2020 by Karuppaiah et al [59]. Gemcitabine (Figure 3G) is an anticancer drug used in the treatment of various cancers, namely pancreas, lung, and breast cancers.…”

Section: Gemcitabine Anticancer Drugmentioning

confidence: 99%

“…Figure11. Profiles of GEM release, free in solution and from GEM-AgNPs, in a phosphate buffer solution (pH = 7.4), for 24 h. Reprinted from[59], with permission from Elsevier, 2021.…”

mentioning

confidence: 99%

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Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

2021

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Since the last decade, nanotechnology has evolved rapidly and has been applied in several areas, such as medicine, pharmaceutical, microelectronics, aerospace, food industries, among others. The use of nanoparticles as drug carriers has been explored and presents several advantages, such as controlled and targeted release of loaded or coupled drugs, and the improvement of the drug’s bioavailability, in addition to others. However, they also have some limitations, related to their in vivo toxicity, which affects all organs including the healthy ones, and overall improvement in the disease treatment, which can be unnoticeable or minimal. Silver nanoparticles have been increasingly investigated due to their peculiar physical, chemical, and optical properties, which allows them to cover several applications, namely in the transport of drugs to a specific target in the body. Given the limitations of conventional cancer chemotherapy, which include low bioavailability and the consequent use of high doses that cause adverse effects, strategies that overcome these difficulties are extremely important. This review embraces an overview and presentation about silver nanoparticles used as anticancer drug carrier systems and focuses a discussion on the state of the art of silver nanoparticles exploited for transport of anticancer drugs and their influence on antitumor effects.

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Section: Biotoxicitymentioning

confidence: 99%

Section: Gemcitabine Anticancer Drugmentioning

confidence: 99%

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Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

2021

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“…Silver nanoparticles have a special role in modern anticancer therapy, being explored for detection and diagnosis of malignant tumors [ 232 , 233 ], controlled and externally triggered drug delivery systems [ 234 , 235 ]. In a similar way with the antimicrobial activity of AgNPs, their efficiency against cancer cells require the cellular uptake of nanosilver, which can be acquired by diffusion, phagocytosis, pinocytosis and receptor-mediated endocytosis [ 236 , 237 ].…”

Section: Silver Nanoparticles For Cancer Therapymentioning

confidence: 99%

“…The same cytotoxic effects were evidenced after cellular treatment with AgNPs biosynthesized with extract from Ochradenus arabicus medicinal shrub [ 251 ] and marine bacilli [ 252 ]. Synergistic toxicity against breast cancer cells were reported by using Capecitabine-loaded citrate-capped AgNPs [ 253 ] and Gemcitabine-loaded PVP-stabilized nanosilver [ 235 ].…”

Section: Silver Nanoparticles For Cancer Therapymentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines

Jalalpour Choupanan,

Shahbazi,

Reiisi

2023

Mol Biol Rep

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Synergistic and enhanced anticancer effect of a facile surface modified non-cytotoxic silver nanoparticle conjugated with gemcitabine in metastatic breast cancer cells

Cited by 19 publications

References 52 publications

Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

An Updated Review on Silver Nanoparticles in Biomedicine

Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines

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