Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

Pharmaceutical interventions by collaboration between staff pharmacists and clinical pharmacists and implementation of Joint Commission International Accreditation Standards on medication use may optimize pharmacotherapy in geriatric patients

“…Kon et al23 published a 2- and 6-month follow-up clinical comparative study with similar findings; the intervention effective peak was at ∼6–8 weeks and the residual effectiveness was up to 6 months. However, HA injection serves as a transient synovial fluid supplement when endogenous HA in the synovial joint decreases in concentration and production during the process of degeneration; HA injection also provides further metabolic anti-inflammatory effects by normalizing the synthesis of endogenous HA and induces chondroprotection 5,7,27. Some case series have already reported the positive result of combined HA and PRP for pressure sore and wound healing 28–30.…”

“…A recent study showed the potential of combined use of HA and PRP due to the different mechanisms in reducing inflammation, indicated by decreased IL-6 and synoviocyte matrix metalloproteinase-13 expression 21. Moreover, another study by Chen et al27 revealed that the combined use of PRP and HA can promote chondrogenesis of OA chondrocytes in both cell and animal models. Therefore, the combined use of HA and PRP is considered to provide a better method to treat knee OA.…”

Naringin Protects Against Cartilage Destruction in Osteoarthritis Through Repression of NF-κB Signaling Pathway

“…To investigate the therapeutic function of recombinant PGRN, 10-week-old WT mice (n=6, respectively) were anesthetized, and the anterior cruciate ligament (ACL) of right knee joint was transected as previously reported [11], followed by oral administration of 100 mg/kg naringin or PBS once a day for 4 weeks. The left knee joint was sham-operated, in which the joint was prepared using the same approach as that for the right knee joint but without any ligament transection.…”

Platelet-rich Plasma in Orthopedics: Efficacy, Evidence, and Evolution of Our Understanding over 10 Years

“…We are looking at using PRP and HA combinations, which has also been supported by a few trials with contradictory results. [38][39][40][41] Currently, there are issues regarding the right formulation, dosage, and sequence and we are on our way to answer that research question through our animal study. We are also working toward more efficient delivery of PRP into knee joint, by combining PRP with various biocompatible nanoparticles with a hope of delivering targeted and controlled release which we hypothesize to be better than the present traditional PRP.…”