Synergistic Ameliorative Effects of Resveratrol with Leflunomide on Serum Levels of Inflammatory Biomarkers and Joint Damage in Rats with Adjuvant Arthritis
Abstract:Background: Rheumatoid arthritis (RA) is chronic irreversible inflammatory disorder and characterized by the thickening of synovial tissue with pannus formation and the destruction of joint structure; due to persistent overproduction of proinflammatory cytokines (TNF-α and IL-6), proinflammatory enzymes such as cyclooxygenase II (COX-2) and matrix metalloproteinases. Leflunomide, potent pyrimidine biosynthesis inhibitor, exhibiting anti-inflammatory and immunosuppressive actions and resveratrol is a potent ant… Show more
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