Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology

Głowacka, Urszula; Brzozowski, T; Magierowski, Marcin

doi:10.3390/biom10030445

Cited by 24 publications

(14 citation statements)

References 85 publications

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“…While Bacteroides is not typically viewed as an important genus for H 2 S production (46), many Bacteroides strains process the necessary enzymes for cysteine-to-H 2 S conversion (52, 53). H 2 S has been proposed to have both anti-inflammatory and proinflammatory effects on the human host depending on a number of increasingly understood factors (54–56), including whether H 2 S is synthesized endogenously by mucosal epithelial cells or derived from the gut microbiota (43, 57). More specifically, H 2 S synthesized by the gut microbiota through cysteine degradation has been proposed to promote gut health at relatively low concentrations (47).…”

Section: Discussionmentioning

confidence: 99%

Interrogation of the Perturbed Gut Microbiota in Gouty Arthritis Patients Throughin silicoMetabolic Modeling

Henson

2020

Preprint

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Recent studies have shown perturbed gut microbiota associated with gouty arthritis, a metabolic disease in which an imbalance between uric acid production and excretion leads to the deposition of uric acid crystals in joints. To mechanistically investigate altered microbiota metabolism in gout disease, 16S rRNA gene amplicon sequence data from stool samples of gout patients and healthy controls were computationally analyzed through bacterial community metabolic modeling. Patient-specific models were used to cluster samples according to their metabolic capabilities and to generate statistically significant partitioning of the samples into a Bacteroides-dominated, high gout cluster and a Faecalibacterium-elevated, low gout cluster. The high gout cluster samples were predicted to allow elevated synthesis of the amino acids D-alanine and L-alanine and byproducts of branched-chain amino acid catabolism, while the low gout cluster samples allowed higher production of butyrate, the sulfur-containing amino acids L-cysteine and L-methionine and the L-cysteine catabolic product H2S. The models predicted an important role for metabolite crossfeeding, including the exchange of acetate, D-lactate and succinate from Bacteroides to Faecalibacterium to allow higher butyrate production differences than would be expected based on taxa abundances in the two clusters. The surprising result that the high gout cluster could underproduce H2S despite having a higher abundance of H2S-synthesizing bacteria was rationalized by reduced L-cysteine production from Faecalibacterium in this cluster. Model predictions were not substantially altered by constraining uptake rates with different in silico diets, suggesting that sulfur-containing amino acid metabolism generally and H2S more specifically could be novel gout disease markers.

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Section: Discussionmentioning

confidence: 99%

Interrogation of the Perturbed Gut Microbiota in Gouty Arthritis Patients Throughin silicoMetabolic Modeling

Henson

2020

Preprint

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“…Hydrogen sulfide (H 2 S) is produced from from L-cysteine by cistationine-γ-lyase. Hydrogen sulfide (H 2 S) increases the activity of N -methyl-D-aspartate receptor and β-adrenergic receptors through a cAMP-dependent protein kinase and activates NOS and the hemoxygenase favoring the formation of Nitric oxide (NO) and carbon monoxide (CO) from heme metabolism [ 134 ]. Hydrogen sulfide (H 2 S) is a metal ligand that reacts with other biological electrophilic sulfur species such as hydropersulfide (RSSR) and sulfenic acid (RSOH) [ 135 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka

Vécsei

2020

Biomedicines

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Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by a wide range of motor, autonomic, and psychobehavioral symptoms, including depression, anxiety, and dementia. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients provide evidence on the disturbance of reduction-oxidation (redox) homeostasis, such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discusses the components of redox homeostasis, including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species cover frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive, as well as pro-oxidative stressors. The antioxidative enzyme systems cover the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring the battery of reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products helps to evaluate the redox status of MS patients to expedite the building of personalized treatment plans for the sake of a better quality of life.

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“…Hydrogen sulfide (H2S) is produced from from L-cysteine by cistationine-γ-lyase. Hydrogen sulfide (H2S) increases the activity of N-methyl-D-aspartate receptor (NMDA) and βadrenergic receptors through a cAMP-dependent protein kinase and activates NOS and the hemoxygenase favoring the formation of Nitric oxide (NO) and carbon monoxide (CO) from heme metabolism [91]. Hydrogen sulfide (H2S) is a metal ligand that reacts with other biological electrophilic sulfur species such as hydropersulfide (RSSR) and sulfenic acid (RSOH) [92].…”

Section: Reactive Sulfur Speciesmentioning

confidence: 99%

“…Superoxide (O2 −• ) anion is one of reactive nucleophilic species and powerful reducing agent under physiological conditions, which initiates reaction cascades generating another ROS such as hydrogen peroxide (H2O2) and sulfur dioxide (SO2) derivatives. Hydrogen sulfide (H2S), thiolate (RS − ), hydropersulfide (RSS -) and disulfide (RSSR) are reactive nucleophilic species that can participate in nucleophilic substitution in vivo [91]. Selenium is more nucleophilic than sulfur due to its greater electron density.…”

Section: Reactive Nucleophilic Speciesmentioning

confidence: 99%

Monitoring the Redox Status in Multiple Sclerosis

Tanaka¹,

Vécsei²

2020

Preprint

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Worldwide, over 2.2 million people are suffered from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system, characterized by multifocal inflammatory or demyelinating attacks associated with neuroinflammation and neurodegeneration. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients evidenced the presence of reduction-oxidation (redox) homeostasis disturbance such as the alternations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discussed the components of redox homeostasis including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species covered frequently discussed reactive oxygen/nitrogen species, rarely featured reactive chemicals such as sulfur, carbonyls, halogens, selenium, and nucleophilic species that potentially act as reductive as well as pro-oxidative stressors. The antioxidative enzyme systems covered the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway, a possible biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed, some of which turned to be MS subtype- or treatment-specific and thus potentially become diagnostic, prognostic, predictive, and/or therapeutic biomarkers. Finally, monitoring a battery of redox components including oxidative, antioxidative and degradation products helps evaluate the redox status of MS patients, which expedites prolongation of remission, relapse prevention, and building personalized treatment plans.

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Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology

Cited by 24 publications

References 85 publications

Interrogation of the Perturbed Gut Microbiota in Gouty Arthritis Patients Throughin silicoMetabolic Modeling

Interrogation of the Perturbed Gut Microbiota in Gouty Arthritis Patients Throughin silicoMetabolic Modeling

Monitoring the Redox Status in Multiple Sclerosis

Monitoring the Redox Status in Multiple Sclerosis

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