Synergism of Hydrochlorothiazide and Nifedipine on Blood Pressure Variability Reduction and Organ Protection in Spontaneously Hypertensive Rats

Xie, He-Hui; Zhang, Xiaofei; Chen, Yuanyuan; Shen, Fu‐Ming; Su, Ding‐Feng

doi:10.1291/hypres.31.685

Cited by 21 publications

(21 citation statements)

References 32 publications

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“…Based on this consideration, we examined the effect of various antihypertensive treatments on cardiac hypertrophy. antihypertensives have been reported to have an effect on cardiac hypertrophy in SHr (32,33). in this study, there were no significant differences between the corrected heart and lV weights; the level of cardiac hypertrophy prevention in the treatment groups was almost the same.…”

Section: Bsupporting

confidence: 40%

Combination therapy based on the angiotensin receptor blocker olmesartan for vascular protection in spontaneously hypertensive rats

Tomita¹

2009

Mol Med Rep

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Abstract. For hypertension, combination therapies are recommended to acheive a low target blood pressure. in this study, the efficacy of combination therapies for preventing organ damage was investigated in spontaneously hypertensive rats (SHr). Twenty-week-old male SHr were orally administered olmesartan (Olm) (5 mg/kg/day) for the first 4 weeks. Subsequently, rats were randomly divided into 5 groups and administered add-on drugs for another 4 weeks as follows: olm+olm (5 mg/kg/day), olm+azelnidipine (aze) (30 mg/kg/ day), olm+temocapril (Tem) (10 mg/kg/day), olm+atenolol (ate) (5 mg/kg/day), olm+hydrochlorothiazide (HcTZ) (5 mg/kg/ day). Blood pressure and heart rate were measured at weeks 0, 4 and 8 by the tail-cuff method. Heart and kidney weights were determined, and endothelial function was assessed by evaluating the dilator response to acetylcholine. in comparison to untreated control SHR, a significant reduction in systolic blood pressure was observed at weeks 4 and 8 in all groups (p<0.05), while heart rate was significantly reduced at week 8 in only the olm+aze and olm+ate groups (p<0.05). in all groups, heart but not kidney weight was significantly decreased (p<0.05), and endothelial function was significantly improved (p<0.05) compared to the control SHr. in the olm+olm, olm+Tem and olm+aze groups, endothelial function was significantly improved as compared to the other treatment groups (p<0.05). Thus, when using an angiotensin receptor blocker as a first-line therapy, an antihypertensive in the form of an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, or calcium channel blocker, such as azelnidipine, should be used as a second-line drug to protect against vascular damage.

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Section: Bsupporting

confidence: 40%

Combination therapy based on the angiotensin receptor blocker olmesartan for vascular protection in spontaneously hypertensive rats

Tomita¹

2009

Mol Med Rep

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“…These results suggest that long-term treatment with a combination of hydrochlorothiazide and nifedipine results in a significant synergistic effect on BPV reduction and organ protection in SHR, and the decrease in BPV may contribute importantly to the observed effect of organ protection. Thus, the study by Xie et al (13) in this issue not only provides new evidence but also novel insights into the relationship between BPV and organ damage in hypertension. Although their experimental data reveal that therapeutic intervention has a clear effect on BPV and organ damage in hypertension, these experimental observations need to be validated in hypertensive subjects.…”

mentioning

confidence: 90%

“…In this issue of Hypertension Research, the same authors further address the effects of a hydrochlorothiazide-nifedipine combination on hemodynamic parameters and organ protection in spontaneously hypertensive rats (SHR) (13). They found that long-term treatment with this combination produces a significant synergistic effect on BPV reduction, baroreflex sensitivity enhancement, and organ protection in SHR.…”

mentioning

confidence: 99%

Blood Pressure Variability Reduction and Organ Protection in Hypertension Treatment

Chen

2008

Hypertens Res

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“…In another report, long-term administration of nitrendipine has been shown to prevent target organ damage in spontaneously hypertensive rats and the beneficial effect was closely related to the attenuation of long-term systolic BPV but not to BP level [77]. In addition to these findings, research from Xie et al also demonstrates the existence of a synergism of different antihypertensive drug combinations, including nitrendipine/atenolol and hydrochlorothiazide/nifedipine, in the decrease of BPV and organ protection in spontaneously hypertensive rats [78,79].…”

Section: Preclinical Evidencementioning

confidence: 99%

Blood Pressure Variability: Prognostic Value and Therapeutic Implications

Höcht

2013

ISRN Hypertension

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Blood pressure variability (BPV) is considered nowadays a novel risk factor for cardiovascular disease. Early findings in sinoaortic denervated rats have clearly shown that enhanced fluctuation of blood pressure induced left ventricular hypertrophy, vascular stiffness, and renal lesion. A large number of clinical trials confirm that short-term and long-term blood pressure variability independently contributes to target organ damage, cardiovascular events, and mortality not only in hypertensive patients but also in subjects with diabetes mellitus and chronic kidney disease. Therefore, amelioration of BPV has been suggested as an additional target of the treatment of cardiovascular diseases. Preliminary evidence obtained from meta-analysis and controlled clinical trials has shown that antihypertensive classes differ in their ability to control excessive BP fluctuations with an impact in the prevention of cardiovascular events. Calcium channel blockers seem to be more effective than other blood pressure lowering drugs for the reduction of short-term and long-term BPV. In order to increase actual knowledge regarding the prognostic value and therapeutic significance of BPV in cardiovascular disease, there is a need for additional clinical studies specifically designed for the study of the relevance of short-term and long-term BPV control by antihypertensive drugs.

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Synergism of Hydrochlorothiazide and Nifedipine on Blood Pressure Variability Reduction and Organ Protection in Spontaneously Hypertensive Rats

Cited by 21 publications

References 32 publications

Combination therapy based on the angiotensin receptor blocker olmesartan for vascular protection in spontaneously hypertensive rats

Combination therapy based on the angiotensin receptor blocker olmesartan for vascular protection in spontaneously hypertensive rats

Blood Pressure Variability Reduction and Organ Protection in Hypertension Treatment

Blood Pressure Variability: Prognostic Value and Therapeutic Implications

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