Synergism of CAY-1 with Amphotericin B and Itraconazole

Lucca, Anthony J. De; Bland, John M.; Boué, Stephen M.; Vigo, C. B.; Walsh, Thomas J.

doi:10.1159/000095959

Cited by 14 publications

(5 citation statements)

References 11 publications

(6 reference statements)

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“…The results of our experiment showed that gentamicin decreased the dose of T. terrestris, so it had a synergistic effects with gentamicin. The synergistic effects of saponins with amphotericin B, itraconazole [31], mancozeb [32], and vancomycin [33] were confirmed, while saponins had no synergistic effects with ampicillin, streptomycin and ciprofloxacin against clinical isolates [27]. The synergy between T. terrestris methanol extract and gentamicin were confirmed by two methods in this study and are reported for the first time.…”

Section: Antibacterial Activity Of Tribulus Terrestris Methanol Extrasupporting

confidence: 66%

Antibacterial activity of Tribulus terrestris methanol extract against clinical isolates of Escherichia coli

Batoei

Mahboubi²,

Yari

2016

Herba Polonica

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S u m m a r yIntroduction: Tribulus terrestris L. is traditionally used for treatment of urinary tract infections. Escherichia coli, as the most prominent agent of urinary tract infections, can be sensitive to T. terrestris extract. Objectives: The aim of this study was to evaluate the antibacterial activity of T. terrestris methanol extract against clinical isolates of E. coli from urinary tract infections. Saponins were determined as main constituents of T. terrestris methanol extract. Methods: The antibacterial activities of T. terrestris methanol extract were evaluated by micro-broth dilution assay. The synergistic effects of T. terrestris methanol extract were screened with gentamicin by micro titer plate and disc diffusion assays. The isobologram curve was figured and the Fractional Inhibitory Concentration Index (FICI) was determined. Results: The saponin content of T. terrestris methanol extract was 54% (w/w). The means of MIC and MBC values for E. coli clinical isolates (n=51) were 3.5±0.27 and 7.4±0.5 mg/ml while these amounts were 3.9±1.3 and 6.4±1.8 µg/ml for gentamicin. T. terrestris methanol extract and gentamicin had synergistic effect with FICI equal to 0.1375. Conclusion: Therefore, T. terrestris can be applicable as alternative treatment in management of urinary tract infections.

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Section: Antibacterial Activity Of Tribulus Terrestris Methanol Extrasupporting

confidence: 66%

Antibacterial activity of Tribulus terrestris methanol extract against clinical isolates of Escherichia coli

Batoei

Mahboubi²,

Yari

2016

Herba Polonica

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“…In addition, antifungal drugs can cause toxic or adverse drug reactions. For example, the polyene antifungal, amphotericin B, has a broad range of activity but is limited in its use due to numerous adverse effects [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, thermal, crystal characterization and biological activity of [Ni(phen)3][Ni(dipic)2]2.17H2O (H2dipic:pyridine-2,6-dicarboxylic acid, phen: 1,10-phenanthroline)

Çolak

Yeşılel

et al. 2010

JICS

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The new {[Ni(phen) 3 ][Ni(dipic) 2 ]} 2 .17H 2 O (1) (phen = 1,10-phenanthroline, dipic = dipicolinate)) has been prepared and characterized by elemental analysis, IR, UV-Vis, magnetic measurement and single crystal X-ray diffraction. The complex consists of two tris(1,10-phenanthroline)nickel(II) cations, two bis(dipicolinato)nickelate(II) anions and seventeen uncoordinated water molecules. The Ni(II) complex crystallizes in the triclinic space group P-1. The complex consisting of cation has distorted octahedral coordination by three bidentate phen ligands. In the complex anion, each dipic ligand simultaneously exhibits tridentate coordination modes through N atom of pyridine ring and oxygen atoms of the carboxylate groups. The crystal packing of 1 is a composite of intermolecular hydrogen bonding, ʌ-ʌ and C-H···ʌ interactions. The complex has also been investigated in terms of biological activity and it showed high activity against S. aureus from Gram positive bacteria and C. albicans from yeast tested.

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“…A previous report showed that CAY-1 (Fig. 1), a saponin from cayenne pepper (Capsicum frutescens), had fungicidal activities against Candida albicans and Aspergillus species [7].…”

Section: Introductionmentioning

confidence: 96%

“…CAY-1 also enhanced the activity of amphotericin B and itraconazole against the same organisms [7,8]. The aim of this study was to evaluate the in vitro activity of CAY-1 against both conidia and hyphae of dermatophytes, since it is not known whether the antifungal susceptibilities of these two morphological forms are similar.…”

Section: Introductionmentioning

confidence: 99%

In vitroactivity of CAY-1, a saponin fromCapsicum frutescens, againstMicrosporumandTrichophytonspecies

et al. 2008

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Dermatomycoses are among the world's most common diseases and their incidence has increased over recent years, particularly in immunosuppressed patients. In previous studies, the saponin CAY-1 from cayenne pepper (Capsicum frutescens), has shown antifungal activities against Candida albicans and Aspergillus spp. We therefore studied the in vitro antifungal activity of CAY-1 against non-germinating conidia and hyphae of clinical isolates of the dermatophytes Trichophyton mentagrophytes, T. rubrum, T. tonsurans and Microsporum canis. We used a microdilution method to assess the growth inhibitory activities of CAY-1 against conidia (CLSI document M38-A) and a colorimetric procedure (XTT method) to investigate the metabolic inhibitory activity of CAY-1 against hyphae. The minimal inhibitory concentrations (complete visual growth inhibition) of CAY-1 against non-germinating conidia ranged from 10-20 microg/ml for all dermatophyte isolates included in this investigation. In addition, we found >90% inhibition of hyphal metabolic activity of these same isolates with 10-20 microg/ml of CAY-1. Results indicate that CAY-1 merits further investigation as a potential agent for the treatment of dermatomycoses.

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Synergism of CAY-1 with Amphotericin B and Itraconazole

Cited by 14 publications

References 11 publications

Antibacterial activity of Tribulus terrestris methanol extract against clinical isolates of Escherichia coli

Antibacterial activity of Tribulus terrestris methanol extract against clinical isolates of Escherichia coli

Synthesis, spectroscopic, thermal, crystal characterization and biological activity of [Ni(phen)3][Ni(dipic)2]2.17H2O (H2dipic:pyridine-2,6-dicarboxylic acid, phen: 1,10-phenanthroline)

In vitroactivity of CAY-1, a saponin fromCapsicum frutescens, againstMicrosporumandTrichophytonspecies

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