Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility

Yarosh, Sergey L.; Кохтенко, Е. В.; Churnosov, Mikhail; Атаман, Олександр Васильович; Solodilova, Maria; Polonikov, Alexey

doi:10.1016/j.rbmo.2014.04.008

Cited by 13 publications

(11 citation statements)

References 70 publications

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“…This approach was proposed to overcome a problem of contradictory results between genetic association studies of male infertility and to better understand the mechanisms by which environmental factors provoke the disease in genetically susceptible men. Although such investigations are yet in their infancy, the results of our recent studies clearly demonstrated that oxidant and antioxidant exposures of the environment may potentiate the development of male infertility and their effects mediated by polymorphic genes for antioxidant and xenobiotic‐metabolising enzymes (Yarosh et al ., , ). It is known that smoking status may mask the relationship between polymorphism of GST genes and male infertility risk.…”

Section: Discussionmentioning

confidence: 97%

“…Although exact reasons of inconsistent results across the genetic association studies in different ethnicities are not yet fully understood, the absence of association between GST genes alone and male infertility risk in some populations of the world may be attributed to gene–gene and gene–environment interactions within the framework of common metabolic pathway of xenobiotic biotransformation determined by the enzymes. In particular, our recent studies (Yarosh et al ., , ) demonstrated an importance of gene–environment interactions analysis for better understanding the role of genes for xenobiotic‐metabolising enzymes in the pathogenesis of idiopathic infertility in men. This study was designed to investigate a comprehensive contribution of GSTM1 , GSTT1 and GSTP1 gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men.…”

Section: Introductionmentioning

confidence: 99%

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Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

et al. 2014

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Inconsistent results of association studies investigated the role of glutathione S-transferase genes in idiopathic male infertility may be explained by ethnical differences in gene-gene and gene-environm ent interactions. In this study, we investigated a joint contribution of GSTM1, GSTT1 and GSTP1 gene polym or phisms and cigarette smoking to the risk of idiopathic infertility in Russian men. DNA samples from 203 infertile and 227 fertile m en were genotyped by a multiplex polymerase chain reaction (GSTM1 and GSTT1 deletions) and PCRrestriction fragment length polym orphism (GSTP1 I105V) methods. The GSTP1 genotype 105IV was associated with increased risk of male infertility (OR = 1.50 95% Cl 1.02-2.20 P = 0.04). Genotype com binations GSTP1 10511/ GSTT1 del (Gl), GSTM1 delIGSTT1 del (G2) and GSTM1 + IGSTT1 del (G3) were associated with decreased risk of male infertility (P < 0.003), whereas a genotype com bination GSTP1 1051V/GSTT1 + (G4) was associated with increased disease risk (P = 0.001). The genotype com binations G3 and G4 showed a significant association with infertility in smokers; however, nonsm ok ers carriers did show the disease risk. In conclusion, GSTM1, GSTT1 and GSTP1 genes are collectively involved in the development of idiopathic male infertility and their phenotypic effects on the disease risk are potentiated by cigarette smoking.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

et al. 2014

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“…N-acetyltransferase (NAT2) is a xenobiotic metabolism enzyme that plays a role in the detoxification of toxicants of tobacco, such as hydrazines, aromatic amines, and arylamines. Hypoacetylated genotypes of NAT2 have been shown to be associated with a link between cigarette smoking and infertility, presumably by increasing ROS production and OS (odds ratio [OR]=1.71, 95% confidence interval [CI]=1.02~2.87, p=0.042) [ 145 ].…”

Section: Smoking-related Genetic Epigenetic and Molecular Alterationmentioning

confidence: 99%

Smoking and Male Infertility: An Evidence-Based Review

Harlev

Agarwal

Güneş

et al. 2015

World J Mens Health

214

131

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Many studies have reported that the contents of cigarette smoke negatively affect sperm parameters, seminal plasma, and various other fertility factors. Nevertheless, the actual effect of smoking on male fertility is not clear. The effect of smoking on semen parameters is based on the well-established biological finding that smoking increases the presence of reactive oxygen species, thereby resulting in oxidative stress (OS). OS has devastating effects on sperm parameters, such as viability and morphology, and impairs sperm function, hence reducing male fertility. However, not all studies have come to the same conclusions. This review sheds light upon the arguable association between smoking and male fertility and also assesses the impact of non-smoking routes of tobacco consumption on male infertility. It also highlights the evidence that links smoking with male infertility, including newly emerging genetic and epigenetic data, and discusses the clinical implications thereof.

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“…Male infertility is a complex multifactorial disease, and in approximately half of the cases the aetiology is unknown (Krausz et al, 2015). It is widely believed that genetic factors may play an important role in male infertility (Sen et al, 2016;Yarosh et al, 2014;Zhang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Impact of CAG repeat length in the androgen receptor gene on male infertility – a meta-analysis

Xiao

Lan

Lin

et al. 2016

Reproductive BioMedicine Online

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CAG repeats are polymorphic nucleotide repeats present in the androgen receptor gene. Many studies have estimated the association between CAG repeat length and male infertility, but the conclusions are controversial. Previous meta-analyses have come to different conclusions; however, new studies have been published. An updated meta-analysis was conducted. PubMed, CBM, CNKI and Web of Science databases were systematically searched for studies published from 1 January 2000 to 1 October 2015. Case-control studies on the association between CAG repeat length and male infertility using appropriate methodology were included. Forty studies were selected, including 3858 cases and 3161 controls. Results showed statistically significantly longer CAG repeat length among cases compared with controls (SMD = 0.14; 95% CI, 0.02-0.26). Shorter repeat length was associated with a lower risk of male infertility compared with a longer repeat length in the overall analysis (OR = 0.79, 95% CI: 0.66-0.95). Moreover, CAG repeat length was associated with male infertility in Caucasian populations, but not Asian or Egyptian populations. Subgroup analysis revealed no significant difference in German populations, but CAG repeat length was associated with male infertility in China and the USA. There were no significant differences between cases and controls in azoospermia and severe oligozoospermia.

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Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility

Cited by 13 publications

References 70 publications

Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

Smoking and Male Infertility: An Evidence-Based Review

Impact of CAG repeat length in the androgen receptor gene on male infertility – a meta-analysis

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