Synergism between oral paracetamol and nefopam in a murine model of postoperative pain

Cabañero, David

doi:10.1002/ejp.1787

Cited by 4 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A single dose of nefopam might be insufficient to control moderate pain in an ACDF or lumbosacral spine operation. In a previous study, [ 22 ] an animal model showed a synergistic antinociceptive interaction between low doses of nefopam and paracetamol to treatment of postoperative hypersensitivity to peripheral stimuli. In both groups, all patients received oral paracetamol which may cover mild to moderate postoperative pain after anterior cervical surgery.…”

Section: Discussionmentioning

confidence: 99%

Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial

et al. 2022

View full text Add to dashboard Cite

Background: Nefopam is a non-opioid, non-nonsteroidal anti-imflammatory drug, analgesic drug that inhibits the reuptake of serotonin, norepinephrine, and dopamine. It is widely used as an adjuvant for pain. This study investigated whether the intraoperative, intravenous infusion of nefopam (20 mg) reduces postoperative morphine consumption, pain scores, and alleviates neuropathic pain in patients undergoing cervical spine surgery.Methods: A prospective, paralleled design, randomized study was conducted on 50 patients (aged 18-75 years) in a universitybased hospital. The patients were assigned to an intervention or a control group (25 patients in each). The intervention group received a 1-hour infusion of nefopam (20 mg) before the end of surgery. The control group received normal saline (NSS). The outcome measures were morphine consumption during the first 24 postoperative hours, numerical rating scale (NRS) pain scores, and scores for the Thai version of the Neuropathic Pain Symptom Inventory (NPSI-T) in patients with neuropathic pain and adverse drug reactions. The NPSI-T scores were assessed on the preoperative day, postoperative day 1, 3, 15, and 30. The outcome assessors were blinded to group allocation.Results: Fifty patients were analyzed. During the first 24 postoperative hours, morphine consumption was 8 mg (nefopam) and 12 mg (NSS; P = .130). The intervention and control groups demonstrated no significant differences in the median NRS scores or total NPSI-T scores or adverse drug reactions.Conclusions: A single, intraoperative infusion of 20 mg of nefopam did not significantly reduce postoperative (24 hours) morphine consumption in patients undergoing anterior cervical spine surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…There are few studies evaluating the efficacy of multimodal analgesia on PPP, however an example of its effectiveness can be seen in a breast cancer surgery trial, whereby pain and analgesic consumption was significantly reduced at 3 months in patients that received gabapentin, a mixture of local anesthetic cream, and ropivacaine wound infiltration ( 215 ). Pre-clinical models demonstrate analgesic synergy between clinically approved analgesics, as well as novel pharmacotherapies including a combination of selective Na v 1.7 inhibitors, with baclofen or opioids ( 124 , 216 ). A detailed summary of randomized controlled trials using pharmacological interventions to prevent the development of PPP can be found in the following review ( 202 ).…”

Section: Prevention and Treatment Of Pppmentioning

confidence: 99%

The mechanisms and management of persistent postsurgical pain

2023

View full text Add to dashboard Cite

An estimated 10%–50% of patients undergoing a surgical intervention will develop persistent postsurgical pain (PPP) lasting more than 3 months despite adequate acute pain management and the availability of minimally invasive procedures. The link between early and late pain outcomes for surgical procedures remains unclear—some patients improve while others develop persistent pain. The elective nature of a surgical procedure offers a unique opportunity for prophylactic or early intervention to prevent the development of PPP and improve our understanding of its associated risk factors, such as pre-operative anxiety and the duration of severe acute postoperative pain. Current perioperative pain management strategies often include opioids, but long-term consumption can lead to tolerance, addiction, opioid-induced hyperalgesia, and death. Pre-clinical models provide the opportunity to dissect mechanisms underpinning the transition from acute to chronic, or persistent, postsurgical pain. This review highlights putative mechanisms of PPP, including sensitisation of peripheral sensory neurons, neuroplasticity in the central nervous system and nociceptive signalling along the neuro-immune axis.

show abstract

Nefopam prescribing preferences in French hospitals: results of a survey

Schulz¹,

Lalande²,

Aubrun³

et al. 2022

Pan Afr Med J

View full text Add to dashboard Cite

Synergism between oral paracetamol and nefopam in a murine model of postoperative pain

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 4 publications

References 58 publications

Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial

Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial

The mechanisms and management of persistent postsurgical pain

Nefopam prescribing preferences in French hospitals: results of a survey

Contact Info

Product

Resources

About