Synergism between alpha1-blockade and angiotensin converting enzyme inhibition in essential hypertension

Dickerson, J. E. C.

doi:10.1097/00004872-199112000-00165

Cited by 12 publications

(12 citation statements)

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“…In hypertensive patients, doxazosin lowers blood pressure by selectively inhibiting post-junctional a 1 -adrenergic receptors and antagonizing the stimulant activity of noradrenaline, thereby decreasing systemic vascular stress (Brown & Dickerson, 1991;Englert & Barlage, 1991;Fulton et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

In vivo administration of doxazosin in rats highly decreases serum circulating levels of testosterone through a mechanism involving the testicular renin–angiotensin system

et al. 2007

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Men are at greater risk of cardiovascular and renal diseases than women. Several hypertensive rat models also exhibit gender differences in blood pressure. Although the mechanisms responsible for these gender differences are not clear, androgens have been shown to promote hypertension. Testosterone is produced by Leydig cells under the regulation of catecholamines acting through both alpha- and beta-adrenoceptors. Some investigators have postulated a putative role of angiotensin II (Ang II) in modulating the action of gonadotropin in Leydig cells, inhibiting testosterone production. In the present work, we analysed the potential mechanism by which the testicular renin-angiotensin system (RAS) decreases the serum circulating levels of testosterone after the in vivo administration of the long-acting selective alpha(1)-adrenergic receptor antagonist doxazosin. RAS was analysed through assessment of the activity of its proteolytic regulatory enzymes. We can conclude that the testicular testosterone production, at least in rat, is regulated by catecholamines through a mechanism involving alpha(1)-adrenergic receptors and RAS, with a putative role for Ang III. Because doxazosin is usually used as a pharmacological therapy in the treatment of hypertension and benign prostatic hyperplasia, our results could also indicate that its benefits are due, at least in part, to decreased serum circulating levels of testosterone.

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Section: Introductionmentioning

confidence: 99%

In vivo administration of doxazosin in rats highly decreases serum circulating levels of testosterone through a mechanism involving the testicular renin–angiotensin system

et al. 2007

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“…It has been used in a variety of clinical trials, including various populations of hypertensive patients such as diabetics, the elderly, patients with benign prostatic hyperplasia or hypercholesterolaemia, the obese or Afro-Americans and in combination with all major groups of antihypertensive drugs such as: calciumchannel antagonists, diuretics, β -adrenoreceptor antagonists, ACEIs and ARBs [4,7,[10][11][12]14,17,19,20,22,24,[43][44][45][46][47][48] . In these studies, doxazosin in either standard or GITS formulation was added as a second-or third-line agent.…”

Section: Downloaded By [Eczacibasi Ilac Sanayi] At 15:17 28 Septembermentioning

confidence: 99%

Doxazosin in the current treatment of hypertension

Wykretowicz¹,

Guzik²,

Wysocki³

2008

Expert Opinion on Pharmacotherapy

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In these studies doxazosin in either standard or extended-release formulation was added as a second- or third-line agent. The two formulations of doxazosin, although chemically identical, appear to differ in some other effects. A large proportion of patients demonstrated a favourable blood pressure response with relatively few treatment-associated side effects showing that this drug appears to be a valuable add-on antihypertensive treatment option. Doxazosin reduces blood pressure and additionally influences other risk factors of coronary heart disease. However, it should be clearly stated that the clinical role of 'beyond blood pressure' effects of doxazosin are largely undetermined.

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“…Doxazosin is a long-acting selective a 1 -adrenoceptor antagonist that is effective and well tolerated in the treatment of patients with hypertension [5][6][7][8][9][10]. Doxazosin has also been shown to have a beneficial effect on lipid metabolism after short-term [9] and long-term treatment [11].…”

Section: Introductionmentioning

confidence: 99%