Synergism among Oral Carcinogens. I. Results of the Simultaneous Feeding of Four Tumorigens to Rats

Radomski, Jack L.; Deichmann, William B.; MacDonald, W.E.; Glass, E. M.

doi:10.1097/00043764-196606000-00018

Cited by 5 publications

(7 citation statements)

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“…In the latter study, the authors observed " low-grade hepatic cell carcinomas " in four rats and " nodular adenomatoid hyperplasia " in 1 1 . Other studies with DDT in rats gave no evidence of carcinogenicity (Haag et al, 1950;Cameron and Cheng, 1951 ;Treon and Cleveland, 1955;Klimmer, 1955;Kimbrough et al, 1964;Deichmann et al, 1967 ;Weisburger and Weisburger, 1968), with the possible exception of an increased lung tumor incidence in rats treated with a low dose of DDT (Radomski et al, 1965). A comprehensive review of the biological effects of DDT in animals and man appears in IARC Monograph No.…”

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confidence: 99%

Long‐term administration of ddt or phenobarbital‐na in wistar rats

Rossiz

Ravera

Repetti

et al. 1977

Intl Journal of Cancer

110

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In lifespan studies, outbred male and female Wistar rats were given either technical DDT mixed into the diet at a dose of 500 parts per million (ppm) or phenobarbital-sodium dissolved in drinking water at a dose of 500 ppm. Liver-cell tumors developed in treated animals but not in controls. The incidence of liver tumors was 45% in the DDT-treated group and 44% in the phenobarbital-sodium-group. When evaluated by sex, DDT-treated females and males had incidences of 56% and 35%, respectively, while in the phenobarbital-sodium group, the respective incidences were 32% and 59% in females and males. These data show a varying susceptibility between the sexes, with regard to induction of liver-cell tumors by the two compounds. In both treated groups, the number of nodular tumors per rat and the average size increased with age and were greater in females. None of these tumors and metastasized. Histologically, the liver tumors were nodular growths, which compressed surrounding parenchyma did not infiltrate it. The total incidence of extrahepatic tumors was higher in controls than in treated animals. In this connection, we must mention the apparent, but not significant, reduction of adrenal tumors in treated rats compared to the controls.

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mentioning

confidence: 99%

Long‐term administration of ddt or phenobarbital‐na in wistar rats

Rossiz

Ravera

Repetti

et al. 1977

Intl Journal of Cancer

110

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“…(19). Male and female rats given the other doses of methoxychlor survived about as well as the control rats.…”

Section: Methoxychlor Study Of Haag Et Almentioning

confidence: 90%

Carcinogenicity and Toxicity of Methoxychlor

Reuber¹

1980

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives.Methoxychlor is carcinogenic for the liver of C3H and BALB/c mice and Osborne-Mendel rats, and possibly for the liver of dogs. Methoxychlor is also carcinogenic for the testis of BALB/c male mice, bone of B6C3F1 female mice, and the ovary of Osborne-Mendel female rats. The incidences of carcinomas of the liver were increased in C3H male mice and BALB/c male and female mice fed methoxychlor. There also was an increase in malignant neoplasms at all sites in BALB/c male and female mice. C3H and BALB/c male mice were more susceptible to the carcinogenic effects of methoxychlor than were female mice. BALB/c mice were more susceptible than C3H mice. Osborne-Mendel male and female rats developed significant incidences of carcinomas of the liver. The incidence of sarcomas of the spleen and abdomen, mostly hemangiosarcomas, was increased in male rats. Neoplasms of the pituitary, adrenals, and mammary gland were also increased in methoxychlor-treated female rats. Miniature swine given methoxychlor developed chronic renal disease in relatively short periods of time. There also was hyperplasia of the mammary gland and uterus, suggesting an estrogen-like effect on those organs. Methoxychlor applied to the skin of rabbits caused a dose-related atrophy of the testes, as well as chronic renal disease. Atrophy of the testes and chronic renal disease could not be evaluated in mice and rats because of insufficient data. thoxychlor Rat Study, FDA Methoxychlor Dog Study, FDA Methoxychlor Swine Studies, FDA Methoxychlor Rabbit Study, NCI Methoxychlor Rat Study, and NCI Methoxychlor Mouse Study. Other studies reviewed were by Hodge et al., Radomsky et al., and Deichmann et al. C1 3 CH H CI CH30<3 CH OCH3 DDT METHOXYCHLOR FDA Methoxychlor Mouse Study BALB/c (BALB/cJ) and C3H (C3HeB/FeJ) strains male and female mice ingested 750 ppm technical methoxychlor (1,2). Mice, 3 weeks of age, were given the pesticide in ground laboratory meal for periods up to 2 years. There were 100 mice of each strain and sex given methoxychlor, as well as 100 controls of each sex.Tissues from all mice with lesions, as well as tissues from many grossly normal mice, were fixed in 10% formalin. Hematoxylin and eosin November 1980 205This content downloaded from 185.2.32.28 on Wed, 18 Jun 2014 02:05:45 AM All use subject to JSTOR Terms and Conditions

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“…This chemical has a weak estrogenic activity 18 and is degraded poorly in the environment and is persistent in soil. MXC can alter fertility in male and female rats 18 , but no clear positive results have been obtained in the majority of the studies on its potential carcinogenicity 23,35 . In the present stud y, no ute rine pro life ra tive lesions in cluding adenocarcinomas were induced in the ENU+MXC group.…”

Section: Discussionmentioning

confidence: 99%

Modifying Effects of Genistein, 4-Nonylphenol and Methoxychlor on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in RasH2 Transgenic Mice Harboring a Human Prototype C-Ha-ras Gene

et al. 2002

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In our previous study, uterine endometrial atypical hyperplasias and adenocarcinomas were induced in female transgenic mice harboring human proto type c-Ha-ras gene (rasH2 mice) within 22 weeks by a single intraperitoneal injection of N-ethyl-N-nitrosourea (ENU). In order to clarify the modifying effects of genistein (GE), 4-nonylphenol (NP), and methoxychlor (MXC) on uterine endometrial carcinogenesis, female rasH2 mice received an intraperitoneal injection of 120 mg/kg body weight (bw) of ENU, followed by no further treatment, diet containing 250 ppm GE, diet containing 250 ppm NP, or diet containing 1,000 ppm MXC for 24 weeks. Uterine proliferative lesions that were observed in treated groups were composed of endometrial hyperplasias, atypical hyperplasias of the endometrium, and adenocarcinomas. The incidence of adenocarcinomas in the ENU alone, ENU+GE, ENU+NP, and ENU+MXC groups was 55.6, 57.1, 47.1, and 0%, respectively, that in the ENU+MXC group being significantly depressed as compared to the ENU alone group (p<0.05). The incidence of atypical hyperplasias in the ENU+MXC group was also decreased. The results in the present study suggest that 1,000 ppm MXC, but not GE and NP, shows an inhibitory effect on the development of uterine adenocarcinomas in rasH2 mice initiated with ENU. (J Toxicol Pathol 2002; 15: 145-151)

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Synergism among Oral Carcinogens. I. Results of the Simultaneous Feeding of Four Tumorigens to Rats

Cited by 5 publications

References 0 publications

Long‐term administration of ddt or phenobarbital‐na in wistar rats

Long‐term administration of ddt or phenobarbital‐na in wistar rats

Carcinogenicity and Toxicity of Methoxychlor

Modifying Effects of Genistein, 4-Nonylphenol and Methoxychlor on <i>N</i>-ethyl-<i>N</i>-nitrosourea-induced Uterine Carcinogenesis in RasH2 Transgenic Mice Harboring a Human Prototype C-Ha-<i>ras</i> Gene

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