Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment

Zhang, Nisi; Wang, James; Foiret, Josquin; Dai, Zhifei; Ferrara, Katherine W.

doi:10.1016/j.addr.2021.113906

Cited by 30 publications

(21 citation statements)

References 183 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrasound has successfully been used as a minimally invasive diagnostic tool for the detection and follow-up of cancer patients [ 26 , 107 , 121 ] and for analyte detection [ 122 , 123 , 124 , 125 ]. Ultrasound has also been used for cancer treatment due to its effective real-time capabilities in imaging and has more recently been used for drug delivery from responsive hydrogel systems [ 126 , 127 , 128 , 129 , 130 , 131 ]. Like the hydrogel systems used for drug delivery in tissue engineering, these hydrogels were chosen due to their high loading efficiencies, stability, and flexibility [ 17 ].…”

Section: Applications For Cancer Therapymentioning

confidence: 99%

Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels

Yeingst

Arrizabalaga

Hayes

2022

Gels

View full text Add to dashboard Cite

Stimuli-responsive hydrogel drug delivery systems are designed to release a payload when prompted by an external stimulus. These platforms have become prominent in the field of drug delivery due to their ability to provide spatial and temporal control for drug release. Among the different external triggers that have been used, ultrasound possesses several advantages: it is non-invasive, has deep tissue penetration, and can safely transmit acoustic energy to a localized area. This review summarizes the current state of understanding about ultrasound-responsive hydrogels used for drug delivery. The mechanisms of inducing payload release and activation using ultrasound are examined, along with the latest innovative formulations and hydrogel design strategies. We also report on the most recent applications leveraging ultrasound activation for both cancer treatment and tissue engineering. Finally, the future perspectives offered by ultrasound-sensitive hydrogels are discussed.

show abstract

Section: Applications For Cancer Therapymentioning

confidence: 99%

Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels

Yeingst

Arrizabalaga

Hayes

2022

Gels

View full text Add to dashboard Cite

show abstract

“…10,11 In recent decades, viral and nonviral vectors have been widely applied for the delivery of therapeutic nucleic acids including plasmid DNA, siRNA, miRNA, and so on, each with advantages and limitations. 12 Due to their safety and amenable surface functionalization, nonviral gene delivery systems have made great progress. Among these, poly-(ethylenimine) (PEI)-based nanovectors are attractive.…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylenimine)-Cyclodextrin-Based Cationic Polymer Mediated HIF-1α Gene Delivery for Hindlimb Ischemia Treatment

Li,

Lu,

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Hindlimb ischemia is a common disease worldwide featured by the sudden decrease in limb perfusion, which usually causes a potential threat to limb viability and even amputation or death. Revascularization has been defined as the gold-standard therapy for hindlimb ischemia. Considering that vascular injury recovery requires cellular adaptation to the hypoxia, hypoxiainducible factor 1 α (HIF-1α) is a potential gene for tissue restoration and angiogenesis. In this manuscript, effective gene delivery vector PEI-β-CD (PC) was reported for the first application in the hindlimb ischemia treatment to deliver HIF-1α plasmid in vitro and in vivo. Our in vitro finding demonstrated that PC/HIF-1α-pDNA could be successfully entered into the cells and mediated efficient gene transfection with good biocompatibility. More importantly, under hypoxic conditions, PC/HIF-1α-pDNA could up-regulate the HUEVC cell viability. In addition, the mRNA levels of VEGF, Ang-1, and PDGF were upregulated, and transcriptome results also demonstrated that the cell-related function of response to hypoxia was enhanced. The therapeutic effect of PC/HIF-1α-pDNA was further estimated in a murine acute hindlimb ischemia model, which demonstrated that intramuscular injection of PC/HIF-1α-pDNA resulted in significantly increased blood perfusion and alleviation in tissue damage, such as tissue fibrosis and inflammation. The results provide a rationale that HIF-1αmediated gene therapy might be a practical strategy for the treatment of limb ischemia.

show abstract

“…The urgent need for novel, more efficient therapeutic approaches has created new molecular therapeutic options. There is great hope for gene therapy among the various strategies investigated for cancer treatment 1,2 . In the past few years, gene therapy and gene delivery methods for targeting cancer cells have evolved tremendously, leading to new frontiers and opportunities for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Escherichia coli cytosine deaminase: Structural and biotechnological aspects

Vosough,

Vafadar,

Naderi

et al. 2023

Biotech and App Biochem

View full text Add to dashboard Cite

Suicide gene therapy involves introducing viral or bacterial genes into tumor cells, which enables the conversion of a nontoxic prodrug into a toxic‐lethal drug. The application of the bacterial cytosine deaminase (bCD)/5‐fluorocytosine (5‐FC) approach has been beneficial and progressive within the current field of cancer therapy because of the enhanced bystander effect. The basis of this method is the preferential deamination of 5‐FC to 5‐fluorouracil by cancer cells expressing cytosine deaminase (CD), which strongly inhibits DNA synthesis and RNA function, effectively targeting tumor cells. However, the poor binding affinity of toward 5‐FC compared to the natural substrate cytosine and/or inappropriate thermostability limits the clinical applications of this gene therapy approach. Nowadays, many genetic engineering studies have been carried out to solve and improve the activity of this enzyme. In the current review, we intend to discuss the biotechnological aspects of Escherichia coli CD, including its structure, functions, molecular cloning, and protein engineering. We will also explore its relevance in cancer clinical trials. By examining these aspects, we hope to provide a thorough understanding of E. coli CD and its potential applications in cancer therapy.

show abstract

Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment

Cited by 30 publications

References 183 publications

Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels

Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels

Poly(ethylenimine)-Cyclodextrin-Based Cationic Polymer Mediated HIF-1α Gene Delivery for Hindlimb Ischemia Treatment

Escherichia coli cytosine deaminase: Structural and biotechnological aspects

Contact Info

Product

Resources

About