Synergic effect of curcumin or lycopene with irradiation upon oral squamous cell carcinoma cells

Camacho‐Alonso, Fabio; López‐Jornet, Pía; Tudela‐Mulero,

doi:10.1111/odi.12025

Cited by 13 publications

(9 citation statements)

References 54 publications

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“…This result does not automatically exclude lactate generation by amino acid catabolism, as the glutamine pathway has not been described for OSCC and has yet to be revealed. Finally, focusing on combination strategies [116,158,186,244] (Table 2) with different signaling pathways ( e.g. mTOR) [245] that have the potential to eradicate malignant and premalignant clones are warranted [245,246].…”

Section: Discussionmentioning

confidence: 99%

Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

Grimm¹,

Cetindis²,

Lehmann³

et al. 2014

J Transl Med

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BackgroundTumor metabolism is a crucial factor for the carcinogenesis of oral squamous cell carcinoma (OSCC).MethodsExpression of IGF-R1, glycolysis-related proteins (GLUT-1, HK 2, PFK-1, LDHA, TKTL1), mitochondrial enzymes (SDHA, SDHB, ATP synthase) were analyzed in normal oral mucosa (n = 5), oral precursor lesions (simple hyperplasia, n = 11; squamous intraepithelial neoplasia, SIN I-III, n = 35), and OSCC specimen (n = 42) by immunohistochemistry and real-time polymerase chain reaction (qPCR) analysis in OSCC cell lines. Metabolism-related proteins were correlated with proliferation activity (Ki-67) and apoptotic properties (TUNEL assay) in OSCC. Specificity of antibodies was confirmed by western blotting in cancer cell lines.ResultsExpression of IGF-R1, glycolysis-related proteins (GLUT-1, HK 2, LDHA, TKTL1), and mitochondrial enzymes (SDHA, SDHB, ATP synthase) were significantly increased in the carcinogenesis of OSCC. Metabolic active regions of OSCC were strongly correlated with proliferating cancer (Ki-67+) cells without detection of apoptosis (TUNEL assay).ConclusionsThis study provides the first evidence of the expression of IGF-R1, glycolysis-related proteins GLUT-1, HK 2, PFK-1, LDHA, and TKTL1, as well as mitochondrial enzymes SDHA, SDHB, and ATP synthase in the multi-step carcinogenesis of OSCC. Both, hypoxia-related glucose metabolism and mitochondrial oxidative phosphorylation characteristics are associated with the carcinogenesis of OSCC. Acidosis and OXPHOS may drive a metabolic shift towards the pentose phosphate pathway (PPP). Therefore, inhibition of the PPP, glycolysis, and targeted anti-mitochondrial therapies (ROS generation) by natural compounds or synthetic vitamin derivatives may act as sensitizer for apoptosis in cancer cells mediated by adjuvant therapies in OSCC.

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Section: Discussionmentioning

confidence: 99%

Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

Grimm¹,

Cetindis²,

Lehmann³

et al. 2014

J Transl Med

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“…Antioxidant compounds may take the form of synthetic molecules, which have roles through oxidative modification (Lopez-Jornet et al, 2016). Various works have researched the antioxidant potential of lycopene and its act in the protection of chronic diseases, such as cardiovascular disorders and cancers (Camacho-Alonso, López-Jornet, & Tudela-Mulero, 2013). It prevents cells versus the damage caused by chemicals, as it blocks of the membrane lipid per oxidation and radicals (Lopez-Jornet et al, 2016).…”

Section: Stz-caused Dm Induces Oxidative Stress and Then Hyperglycemimentioning

confidence: 99%

Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Saracoğlu¹,

Baş

Pandır

2018

J Food Biochem

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The objective of this current study is to search the impacts of furan and lycopene on a diabetic rat's heart. Diabetes increases prevalence with a sedentary lifestyle and obesity. Furan, a carcinogen, was detected in foods that had undergone thermal treatment. Two groups were formed, such as: the control and diabetic groups. Diabetic groups fall into four allocated groups: control, lycopene, furan, and furan + lycopene. The changes in malondialdehide levels, antioxidant enzymes’ activities, and histopathology of the heart were pointed out. We observed that the changes in both the MDA level and the antioxidant enzymes’ activities were due to diabetes. Furan‐induced increment in MDA levels, but GST, CAT, SOD, and GPx activities showed a decrease. Lycopene influenced these changes positively. In terms of the pathological studies, changes were also observed in diabetic rats. The histological damage in the diabetic furan groups was found to be very serious. Lycopene was protective against furan that caused histopathological changes. Diabetes and furan resulted into heart damages in rats and lycopene showed preventive effects. But this was not a complete protection. Practical applications Furan by product of chlorinated chemical compounds production and chemical processes including combustion, are virtually ubiquitous in the environment. Because of this, furan occur potential risk for human health. Furan is known to exist at higher levels in fatty foods, such as full‐fat milk and dairy products, meat and eggs. They can accumulate in the fatty tissues of animals and humans. Diabetes increase in the prevalence of a sedentary lifestyle and obesity. Diabetes with furan‐induced cardiotoxicity. Foods should not be heated over and over again, especially diabetic heart patients should stay away from this situation.

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“…Camacho-Alonso et al [123] demonstrated that lycopene increases cytotoxic activity of radiotherapy in oral squamous cell carcinoma cells and reduces its invasiveness [123]. Similarly, Tabassum et al [124] reported that lycopene exerts a synergic effect when combined with radiation, in certain types of tumors such as HNSCC and prostate cancer.…”

Section: Potential Mechanisms Of Actions Of Lycopenementioning

confidence: 99%

Multiple Molecular and Cellular Mechanisms of Action of Lycopene in Cancer Inhibition

Trejo-Solís

Pedraza‐Chaverrí

Torres-Ramos

et al. 2013

Evidence-Based Complementary and Alternative Medicine

118

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Epidemiological studies suggest that including fruits, vegetables, and whole grains in regular dietary intake might prevent and reverse cellular carcinogenesis, reducing the incidence of primary tumours. Bioactive components present in food can simultaneously modulate more than one carcinogenic process, including cancer metabolism, hormonal balance, transcriptional activity, cell-cycle control, apoptosis, inflammation, angiogenesis and metastasis. Some studies have shown an inverse correlation between a diet rich in fruits, vegetables, and carotenoids and a low incidence of different types of cancer. Lycopene, the predominant carotenoid found in tomatoes, exhibits a high antioxidant capacity and has been shown to prevent cancer, as evidenced by clinical trials and studies in cell culture and animal models. In vitro studies have shown that lycopene treatment can selectively arrest cell growth and induce apoptosis in cancer cells without affecting normal cells. In vivo studies have revealed that lycopene treatment inhibits tumour growth in the liver, lung, prostate, breast, and colon. Clinical studies have shown that lycopene protects against prostate cancer. One of the main challenges in cancer prevention is the integration of new molecular findings into clinical practice. Thus, the identification of molecular biomarkers associated with lycopene levels is essential for improving our understanding of the mechanisms underlying its antineoplastic activity.

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Synergic effect of curcumin or lycopene with irradiation upon oral squamous cell carcinoma cells

Abstract: Curcumin and lycopene increase cytotoxic activity in the PE/CA-PJ15 cell line and reduce cell migration capacity, while the combination of curcumin or lycopene with irradiation exerts a synergic effect.

Cited by 13 publications

References 54 publications

Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Multiple Molecular and Cellular Mechanisms of Action of Lycopene in Cancer Inhibition

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