Synergic control of action in levodopa-naïve Parkinson’s disease patients: II. Multi-muscle synergies stabilizing vertical posture

Freitas, Sandra Maria Sbeghen Ferreira de; Freitas, Paulo Barbosa de; Falaki, Ali; Corson, Tyler; Lewis, Mechelle M.; Huang, Xuemei; Latash, Mark L.

doi:10.1007/s00221-020-05947-z

Cited by 11 publications

(2 citation statements)

References 65 publications

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“…This was also justified by the fact that for many of our patients it would have been very difficult, or even impossible, to autonomously perform a 5-min walking task in their OFF medication state. In addition, we did not expect to find differences between ON and OFF medication states from the point of view of muscle synergies, from what is already known from the literature 24 , 26 , 27 , 32 . In the perspective of testing PD patients during their best-ON condition, the stimulation parameters (other than the stimulation frequency) were tailored to the specific needs of each patient for obtaining their “best” condition.…”

Section: Discussionmentioning

confidence: 78%

Muscle synergies in Parkinson’s disease before and after the deep brain stimulation of the bilateral subthalamic nucleus

Ghislieri

Lanotte

Knaflitz

et al. 2023

Sci Rep

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The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T0), at 3 months (T1), and at 12 months (T2) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients—that at T0 was smaller with respect to controls (PD T0: 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p = 0.004)—increased at T1 (75.8 ± 1.8%), becoming not different from that of controls at T2 (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.

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Section: Discussionmentioning

confidence: 78%

Muscle synergies in Parkinson’s disease before and after the deep brain stimulation of the bilateral subthalamic nucleus

Ghislieri

Lanotte

Knaflitz

et al. 2023

Sci Rep

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show abstract

“…Trajectory of the slow component (RA) was commonly first separated from the COP trajectory when the horizontal forces reach zero, and then the trajectory of the fast component (TR) was calculated as the deviation of COP from the trajectory of RA. Using this method, the postural control function in different populations (such as in artistic gymnasts [ 27 ], in patients with PD [ 13 , 28 ], and in subjects with neck pain [ 29 ]) was investigated. Moreover, by using the DCRFP system and the Zatsiorsky analysis method, investigation of the effects of dcGVS on dynamic balance is possible.…”

Section: Introductionmentioning

confidence: 99%

Galvanic vestibular stimulation with low intensity improves dynamic balance

Chen

Chai

et al. 2021

Translational Neuroscience

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Background Dynamic balance is associated with fall risk. The aim of this study is to explore the effects of galvanic vestibular stimulation with very low intensity direct current (dcGVS) on dynamic balance. Methodology We used a rocker force platform for assessing the dynamic balance performance. Center-of-pressure (COP) coordinates were acquired and decomposed to rambling (RA) and trembling (TR). We measured sway parameters, including length, average speed, and average range, affected by dcGVS at 0.01 mA with eyes open (EO) and eyes closed (EC). Results We assessed 33 young healthy subjects and found that all sway parameters were shorter in the EO condition, indicating a better dynamic balance performance. dcGVS significantly improved the dynamic balance performance both in EO and EC conditions. All the sway parameters in COP in EO were significantly shorter than those in EC, indicating a better dynamic balance performance in EO. In EO, RA had greater improvement rates than TR. In EC, only average speed had a greater improvement rate in RA, whereas length and average range had greater improvement rates in TR. These results indicate a different modulation model between EO and EC. Conclusion These findings indicate that very low intensity dcGVS improved the sway parameters of dynamic balance in young healthy subjects. Moreover, our results suggest different dynamic balance control models between having EO and EC. The mechanisms of these phenomena caused by very low intensity dcGVS require further investigation.

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One more time about motor (and non-motor) synergies

Latash

2021

Exp Brain Res

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Synergic control of action in levodopa-naïve Parkinson’s disease patients: II. Multi-muscle synergies stabilizing vertical posture

Cited by 11 publications

References 65 publications

Muscle synergies in Parkinson’s disease before and after the deep brain stimulation of the bilateral subthalamic nucleus

Muscle synergies in Parkinson’s disease before and after the deep brain stimulation of the bilateral subthalamic nucleus

Galvanic vestibular stimulation with low intensity improves dynamic balance

One more time about motor (and non-motor) synergies

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