Synergetic toxicity of DATR, a recombinant soluble human TRAIL mutant, in combination with traditional chemotherapeutics in rats

Zou, Yingxin; Zhang, Xiaodong; Mao, Yu; Huang, Mao; Yuan, Bo; Chu, Zun-hua; L, Gao

doi:10.1016/j.yrtph.2012.09.005

Cited by 2 publications

(1 citation statement)

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“…Increases in AST, ALT, BUN, creatinine, LDH and ALP are markers of cellular damage in systemic tissues. Consistent with hepatorenal and gastrointestinal damage caused by CPT-11 application, a significant increase in serum enzyme activities was observed [ 36 , 37 ]. The serum activities of these markers were found to be significantly raised in the CPT-11 group, and NAC significantly reduced these increases and reversed CPT-11 toxicity.…”

Section: Discussionmentioning

confidence: 71%

Investigation of the Possible Protective Effect of N-Acetylcysteine (NAC) against Irinotecan (CPT-11)-Induced Toxicity in Rats

et al. 2022

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Irinotecan (CPT-11) is a chemotherapeutic agent involved in the treatment regimens for several malignancies such as colorectal cancer. N-acetylcysteine (NAC) is a strong antioxidant and anti-inflammatory agent used in the treatment of several diseases related to oxidative stress and inflammation. This study aimed at investigating whether NAC provides protection against hepatorenal and gastrointestinal tissue damage induced by CPT-11. Thirty-two Wistar albino rats were divided into four groups as control, NAC, CPT-11, and CPT-11+NAC. Following the experimental period, blood, and tissue samples (liver, kidney, stomach, and small intestine) were collected, and biochemical indicators, together with pro-inflammatory cytokines (TNF-α and IL-1β), matrix metalloproteinases (MMPs), malondialdehyde (MDA), glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels were evaluated. Both the biochemical indicators and the pro-inflammatory cytokines, MMP, and MDA levels increased in animals treated with CPT-11, while SOD and GPx activities decreased. Histopathological evaluation revealed structural damage in all examined tissues. With NAC administration, significant improvements were observed, both biochemically and histologically. In conclusion, the results of the present study suggest that NAC treatment together with CPT-11 may have a beneficial effect on reducing CPT-11 toxicity in rats, by modulating inflammation and the oxidant–antioxidant balance. These results strongly promote further investigative studies.

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Section: Discussionmentioning

confidence: 71%