Synergetic effect of the Onion CHI gene on the PAP1 regulatory gene for enhancing the flavonoid profile of tomato skin

Lim, Wansang; Li, Jiarui

doi:10.1038/s41598-017-12355-x

Cited by 15 publications

(13 citation statements)

References 48 publications

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“…Based on the knowledge gained by genetic/genomic approaches, vegetables with an increased amount of such compounds via enhanced biosynthesis can be produced through genetic transformation. For instance, co-introduction of the PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1), a regulatory gene from Arabidopsis, and the CHALCONE ISOMERASE (CHI) gene, from Allium cepa, into tomato caused 130-and 30-times higher levels of rutin (a bioactive flavonol) and total anthocyanin content, respectively, than those found in wild tomato skin [86].…”

Section: Production Of Vegetables With Higher Agi Activitymentioning

confidence: 99%

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Assefa

Yang

Chae

et al. 2019

Plants

113

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Type-2 diabetes mellitus is one of the most prevalent metabolic diseases in the world, and is characterized by hyperglycemia (i.e., high levels of glucose in the blood). Alpha-glucosidases are enzymes in the digestive tract that hydrolyze carbohydrates into glucose. One strategy that has been developed to treat type-2 diabetes is inhibition of the activity of alpha-glucosidases using synthetic drugs. However, these inhibitors are usually associated with gastrointestinal side effects. Therefore, the development of inhibitors from natural products offers an alternative option for the control of hyperglycemia. In recent years, various studies have been conducted to identify alpha-glucosidases inhibitors from natural sources such as plants, and many candidates have transpired to be secondary metabolites including alkaloids, flavonoids, phenols, and terpenoids. In this review, we focus on the alpha-glucosidases inhibitors found in common vegetable crops and the major classes of phytochemicals responsible for the inhibitory activity, and also as potential/natural drug candidates for the treatment of type-2 diabetes mellitus. In addition, possible breeding strategies for production of improved vegetable crops with higher content of the inhibitors are also described.Plants 2020, 9, 2 2 of 17 potential α-glucosidase inhibitors (AGIs) have been extensively screened or studied and acarbose, miglitol, voglibose, and 1-deoxynojirimycin (DNJ) are currently commercialized anti-glucosidase drugs (Figure 1; [7]) against type-2 diabetes, a chronic condition in which the body becomes resistant to the normal effects of insulin, resulting in ineffectiveness at managing the blood glucose levels.

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Section: Production Of Vegetables With Higher Agi Activitymentioning

confidence: 99%

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Assefa

Yang

Chae

et al. 2019

Plants

113

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“…The crossing of transgenic lines has been also described in another study, in which tomato lines over-expressing the onion CHI gene and the Arabidopsis PAP1 (Production of Anthocyanin Pigment 1) gene, upregulating the early biosynthetic genes, were crossed to obtain CHI x PAP1 lines. The resulting tomato line accumulated higher levels of rutin and anthocyanins in the fruit skin compared to wild type tomatoes [107]. If in most of the cases, flavonoid biofortification has been realized by classic transgenic approaches, emerging genome editing technologies are revealing their great potential in the improvement of plant food quality.…”

Section: Flavonoids Biofortificationmentioning

confidence: 99%

Looking at Flavonoid Biodiversity in Horticultural Crops: A Colored Mine with Nutritional Benefits

Scarano

Chieppa

Santino

2018

Plants

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Flavonoids represent a wide group of plant secondary metabolites implicated in many physiological roles, from the attraction of pollinators to the protection against biotic or abiotic stresses. Flavonoids are synthetized in a number of horticultural crops that are important components of our daily diet. In the last decades, the consumption of vegetables rich in antioxidants has been strongly promoted from the perspective of prevention/protection against chronic diseases. Therefore, due to their nutritional importance, several attempts have been made to enhance flavonoid levels in species of agronomic interest. In this review, we focus on the flavonoid biodiversity among the major horticultural species, which is responsible of differences among closely related species and influences the qualitative/quantitative composition. We also review the role of flavonoids in the nutritional quality of plant products, contributing to their organoleptic and nutritional properties, and the main strategies of biofortification to increase their content.

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“…CHI is the first enzyme in flavonoid isomerization and usually controls flavonoid isomerization in metabolic pathways (Jiang et al, 2015;Lim and Li, 2017). However, there is not enough information about the light-regulated mechanism of CHI genes in flavonoid biosynthesis in T. hemsleyanum and other plants.…”

Section: Discussionmentioning

confidence: 99%

Physiological Responses of the Tetrastigma hemsleyanum Plant under Different Color Films

Bai¹,

Wen²,

Liu³

et al. 2021

horts

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Tetrastigma hemsleyanum is a traditional Chinese medicine herb, commonly used for its anti-inflammatory and antitumor properties. Flavonoids are the main functional constituents of T. hemsleyanum, and their production in the herb is affected by light quality. T. hemsleyanum is a shade-loving plant and is usually covered by black shade nets during cultivation. However, there are only a few studies on the effects of using color films on growth and flavonoid synthesis in T. hemsleyanum. In this study, we measured the influence of five different color films on growth indexes—sugar, soluble amino acid, soluble protein, and flavonoid content—and flavonoid-synthesizing enzyme activities in T. hemsleyanum. The films used were colorless plastic film as the control group (CK-W), red film (RF), yellow film (YF), green film (GF), and blue film (BF). BF promoted plant growth and increased yield, as evidenced by the highest growth indexes, soluble amino acid content, and chalcone isomerase (CHI) enzyme activity. RF increased the content of secondary metabolites, thereby enhancing herb quality, as evidenced by the highest phenylalanine ammonia lyase (PAL) activity and increased flavonoid content.

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Synergetic effect of the Onion CHI gene on the PAP1 regulatory gene for enhancing the flavonoid profile of tomato skin

Cited by 15 publications

References 48 publications

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Looking at Flavonoid Biodiversity in Horticultural Crops: A Colored Mine with Nutritional Benefits

Physiological Responses of the Tetrastigma hemsleyanum Plant under Different Color Films

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