Syndromes of Disseminated Intravascular Coagulation

Hardaway, Robert M.

doi:10.1097/00000441-196611000-00045

Cited by 63 publications

(24 citation statements)

References 0 publications

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“…intervals) showed a progressive rise. Six of the 19 patients with abnormal tests (9,13,20,23,24,26) had elevated values (greater than 14 sec.) prior to incubation.…”

Section: Amentioning

confidence: 95%

“…2. Coagulation defects and renal or liver dysfunction with or without bleeding: Among the 26 patients with abnormal coagulation tests were 13 (Table I , 9,10,11,18,20,23,26). Seven of the eight had abnormal S T T (two mildly abnormal).…”

Section: Amentioning

confidence: 99%

“…Five patients were on cytoxic drugs (7, 8, (9,23,26). All had sepsis, bleeding, and one or more abnormal coagulation tests.…”

Section: Coagulation Defects and Chemotherapymentioning

confidence: 99%

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Disseminated intravascular coagulation in cancer patients: Supportive evidence

Peck

Reiquam

1973

Cancer

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Coagulation tests including platelet count, factor V assay, fibrinogen, fibrin split products, and serial thrombin time were performed on 51 patients with cancer. Elevated fibrin split products and/or abnormal serial thrombin time was present in 24 (48%) patients. Bleeding occurred in three patients; each had normal platelet counts. However, the serial thrombin time was not normal and/or increased fibrin split products were present. The data add support to the hypothesis that cancer patients do have a delicately balanced coagulation mechanism, and chronic disseminated intravascular coagulation may be induced or aggravated by various stimuli, including radiation therapy, chemotherapy, sepsis, and perhaps other unrecognized situations.

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“…intervals) showed a progressive rise. Six of the 19 patients with abnormal tests (9,13,20,23,24,26) had elevated values (greater than 14 sec.) prior to incubation.…”

Section: Amentioning

confidence: 95%

Section: Amentioning

confidence: 99%

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Disseminated intravascular coagulation in cancer patients: Supportive evidence

Peck

Reiquam

1973

Cancer

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“…The significance of disseminated intravascular coagulation (DIC) as a pathogenic mechanism in various clinical conditions is becoming increasingly appreciated (Hardaway 1966. Massive DIC is associated with low values of platelets and coagulation factors and thus easily detected (Merskey et al 1967, Verstrate & Vermylen 1968).…”

mentioning

confidence: 99%

Discrepancy between Thrombotest and Normotest — an Indicator of Disseminated Intravascular Coagulation (DIC)?

Slaastad

Godal

1972

Scandinavian Journal of Haematology

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A low Thrombotest (IT) value, as compared with Normotest (NT) was found in 64% of 181 unselected medical patients. An NT/TT discrepancy was met with in most disease categories, but there was a significant preponderance of patients with malignant diseases. A positive ethanol test was found in 20 % of patients with a great NT/TT discrepancy, but only in 5 % of patients with no such discrepancy. No other signs of disseminated intravascular coagulation could be demonstrated.

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“…In recent years disseminated intravascular coagulation has been reported to play a role in various apparently different pathological processes (12,17,21,22,24,30,31,33,36). Conditions in which disseminated intravascular coagulation has been considered an important pathogenetic factor are thrombotic thrornbocytopenic purpura, haemolytic uraemic syndrome, renal cortical necrosis, malignant hypertension, liver cirrhosis and hyaline membrane disease, Shwartzman phenomenon and shock of various aetiology (33).…”

mentioning

confidence: 99%