Syndromes and epistemology II: Is autism a polygenic disorder?

Oppositional Defiant and Conduct Disorder Behaviors in Boys With Autism Spectrum Disorder With and Without Attention-Deficit Hyperactivity Disorder Versus Several Comparison Samples

“…ADHD). A related strategy is becoming more widely embraced in molecular biology (e.g., endophenotypes, subphenotypes) (e.g., Fisch 2008;Kendler 2006;Liu et al 2008;Shao et al 2003). Moreover, this study does not resolve the conundrum of whether it is better to characterize behavioral syndromes (e.g., ODD, CD) in children with ASD with symptom characterizations that reflect their social cognition deficits or to use symptom characterizations that apply equally to a wide range of comorbid neurobehavioral syndromes.…”

Oppositional Defiant and Conduct Disorder Behaviors in Boys With Autism Spectrum Disorder With and Without Attention-Deficit Hyperactivity Disorder Versus Several Comparison Samples

“…ADHD). A related strategy is becoming more widely embraced in molecular biology (e.g., endophenotypes, subphenotypes) (e.g., Fisch 2008;Kendler 2006;Liu et al 2008;Shao et al 2003). Moreover, this study does not resolve the conundrum of whether it is better to characterize behavioral syndromes (e.g., ODD, CD) in children with ASD with symptom characterizations that reflect their social cognition deficits or to use symptom characterizations that apply equally to a wide range of comorbid neurobehavioral syndromes.…”

Book review: Autism Spectrum Disorders. Amara David G, Dawson Geraldine, Geschwind Daniel H (Eds.). Oxford University Press: Oxford, UK, 2011

“…However, the neural dysfunction based on evidence from speech and language assessments is weak and often contradictory. A particular sticking point for this reviewer was to have his point of view misrepresented, suggesting that autism was probably polygenic in origin [Fisch, 2008]. In fact, I proposed that autism was probably multi‐monogenic in origin.…”

Oppositional Defiant and Conduct Disorder Behaviors in Boys With Autism Spectrum Disorder With and Without Attention-Deficit Hyperactivity Disorder Versus Several Comparison Samples

“…ADHD). A related strategy is becoming more widely embraced in molecular biology (e.g., endophenotypes, subphenotypes) (e.g., Fisch 2008;Kendler 2006;Liu et al 2008;Shao et al 2003). Moreover, this study does not resolve the conundrum of whether it is better to characterize behavioral syndromes (e.g., ODD, CD) in children with ASD with symptom characterizations that reflect their social cognition deficits or to use symptom characterizations that apply equally to a wide range of comorbid neurobehavioral syndromes.…”

Book review: Autism Spectrum Disorders. Amara David G, Dawson Geraldine, Geschwind Daniel H (Eds.). Oxford University Press: Oxford, UK, 2011

“…However, the neural dysfunction based on evidence from speech and language assessments is weak and often contradictory. A particular sticking point for this reviewer was to have his point of view misrepresented, suggesting that autism was probably polygenic in origin [Fisch, 2008]. In fact, I proposed that autism was probably multi‐monogenic in origin.…”

Oppositional Defiant and Conduct Disorder Behaviors in Boys With Autism Spectrum Disorder With and Without Attention-Deficit Hyperactivity Disorder Versus Several Comparison Samples

“…ADHD). A related strategy is becoming more widely embraced in molecular biology (e.g., endophenotypes, subphenotypes) (e.g., Fisch 2008;Kendler 2006;Liu et al 2008;Shao et al 2003). Moreover, this study does not resolve the conundrum of whether it is better to characterize behavioral syndromes (e.g., ODD, CD) in children with ASD with symptom characterizations that reflect their social cognition deficits or to use symptom characterizations that apply equally to a wide range of comorbid neurobehavioral syndromes.…”

Book review: Autism Spectrum Disorders. Amara David G, Dawson Geraldine, Geschwind Daniel H (Eds.). Oxford University Press: Oxford, UK, 2011

“…However, the neural dysfunction based on evidence from speech and language assessments is weak and often contradictory. A particular sticking point for this reviewer was to have his point of view misrepresented, suggesting that autism was probably polygenic in origin [Fisch, 2008]. In fact, I proposed that autism was probably multi‐monogenic in origin.…”