Syndrome of Nonsyphilitic Interstitial Keratitis and Vestibuloauditory Symptoms

Atypical Cogan's syndrome presenting with bilateral acute glaucoma

“…The Valsalva manoeuvre comprises forcible exhalation against a closed glottis, thereby creating a sudden increase in the intrathoracic or intraabdominal pressure. 1 Spontaneous rupture of peri-foveal capillaries may develop, leading to a characteristic clinical picture of a retinal haemorrhage in an otherwise healthy eye. 2 The haemorrhage typically occurs at the macula and in the vast majority of cases is an isolated and self-limited event.…”

Inaugural description of Cogan syndrome in an HIV-infected person

“…In the CSF, cultures were negative such as were serology for syphilis and PCR for HIV, cytomegalovirus (CMV), herpes simplex-1 and -2, varicella zoster, and Epstein-Barr viruses, and for Sirs: Cogan syndrome is an uncommon disease, characterized by non-syphilitic interstitial keratitis, and cochleovestibular manifestations. The latter look alike severe Ménière's disease and usually lead to deafness in 3 months [1,2]. Almost 60 % of the patients develop systemic manifestations, 10 % of them suffering from life-threatening complications such as a systemic necrotizing vasculitis [3,4].…”

Síndrome de Cogan: achados oculares em um caso da forma atípica

“…Geralmente não resulta em perda visual permanente, porém este aspecto é importante para o diagnóstico precoce e prevenção de surdez irreversível (1) . Inicialmente descrita como entidade clínica em 1945 por David Cogan, ocorre em adultos jovens (20-40 anos) e ainda não há dados de incidência ou prevalência pelo número limitado de pacientes documentados (1,(3)(4)(5) . A etiologia e fisiopatologia desta entidade permanecem desconhecidas (6) , contudo há associação com infecção de vias aéreas superiores precedendo o quadro (7) e hipóteses de prováveis agentes virais (1) .…”