Syndrome of Inappropriate Secretion of ADH (SIADH) Following Cisplatin Administration in a Pulmonary Adenocarcinoma Patient with a Malignant Pleural Effusion.

Kagawa, Koichi; Fujitaka, Kazunori; Isobe, Takeshi; Yamasaki, Masahiro; Miyazaki, Masahito; Oguri, Tetsuya; Kohno, Nobuoki

doi:10.2169/internalmedicine.40.1020

Cited by 17 publications

(8 citation statements)

References 18 publications

(9 reference statements)

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“…Besides paraneoplastic, there is also one case of SIADH in advanced ONB induced by cisplatin (CDDP) [ 48 ]. A similar situation was also reported in some other cancer patients after CDDP administration [ 49 ].…”

Section: Syndrome Of Inappropriate Adh Secretionsupporting

confidence: 87%

Review Paraneoplastic syndromes in olfactory neuroblastoma

Kunc¹,

Gabrych²,

Czapiewski³

et al. 2015

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Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of sinonasal tract, derived from olfactory epithelium. Unilateral nasal obstruction, epistaxis, sinusitis, and headaches are common symptoms. Olfactory neuroblastoma shows neuroendocrine differentiation and similarly to other neuroendocrine tumors can produce several types of peptic substances and hormones. Excess production of these substances can be responsible for different types of endocrinological paraneoplastic syndromes (PNS). Moreover, besides endocrinological, in ONB may also occur neurological PNS, caused by immune cross-reactivity between tumor and normal host tissues in the nervous system. Paraneoplastic syndromes in ONB include: syndrome of inappropriate ADH secretion (SIADH), ectopic ACTH syndrome (EAS), humoral hypercalcemia of malignancy (HHM), hypertension due to catecholamine secretion by tumor, opsoclonus-myoclonus-ataxia (OMA) and paraneoplastic cerebellar degeneration. Paraneoplastic syndromes in ONB tend to have atypical features, therefore diagnosis may be difficult. In this review, we described initial symptoms, patterns of presentation, treatment and outcome of paraneoplastic syndromes in ONB, reported in the literature.

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Section: Syndrome Of Inappropriate Adh Secretionsupporting

confidence: 87%

Review Paraneoplastic syndromes in olfactory neuroblastoma

Kunc¹,

Gabrych²,

Czapiewski³

et al. 2015

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“…However, accumulated effusion in this case was estimated to be only slight through the observation of chest X ray, suggesting that the elevation of the pressure should be limited. Because a previous report about SIADH assuming the involvement of elevated intra-thoracic cavity pressure as a cause of SIADH demonstrates the accumulation of a large amount of effusion which might be more than half of the thoracic cavity [8], the implication of pleural effusion for SIADH was assessed to be not significant in this case. Those findings suggested that SIADH in this case was not the secondary but, rather, the idiopathic type.…”

Section: Discussionmentioning

confidence: 95%

A case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lupus erythematosus in the central nervous system

et al. 2012

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We report on a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lupus erythematosus in the central nervous system (CNS). A 73-year-old woman with essential hypertension suddenly demonstrated consciousness disturbance. Upon her admission, laboratory data showed significant hyponatremia (114 mEq/L) and a lack of body fluid loss. Diminished free water excretion (urine osmolality 684 mOsm/kg) and normal urine Na excretion (FENa 1.70 %) were consistent with the diagnosis of SIADH, which was confirmed by an inappropriately high concentration of plasma antidiuretic hormone (ADH) (15.3 pg/mL at 256 mOsm/kg of plasma osmolality). The hyponatremia was corrected by a combination of oral water intake restriction and saline infusion with furosemide administration until the 20th hospital day. Simultaneously, the presence of exudative pleural effusion in both chest cavities, suggesting the existence of pleuritis, and high titer of anti-nuclear antibody (ANA, 51209) and anti-doublestrand DNA antibody (6500 IU/mL), indicated the subclinical development of systemic lupus erythematosus (SLE), although the diagnostic criteria were not satisfied at that time. On the 34th hospital day, the sudden onset of unknown consciousness disturbance confirmed the diagnosis of SLE as CNS lupus. In previous case reports on SLE and/or SIADH, a few cases in which SLE and SIADH developed concomitantly regularly showed high immunological activities, as in our case. Some common pathophysiological bases might be involved in the concomitant appearance of those disorders.

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“…Hormone: Approximately 10% to 45% of SCLC and 1% of other lung cancer cases (squamous cell carcinoma 58 and adenocarcinoma 59,60 ) produce arginine vasopressin (ie, antidiuretic hormone [ADH]), but only 1% to 5% of patients with lung cancer have symptomatic syndromes of inappropriate ADH (SIADH). 11 Excess ADH activates vasopressin 2 receptors in renal tubules, resulting in increased aquaporins and impaired free water clearance.…”

Section: Syndrome Of Inappropriate Antidiureticmentioning

confidence: 99%