Syndrome of Inappropriate Antidiuretic Hormone Secretion in Cancer of the Head and Neck

Zohar, Yuval; Yp, Talmi; Finkelstein, Yoram; Nobel, Michael; Gafter, Uzi

doi:10.1177/000348949110000415

Cited by 28 publications

(22 citation statements)

References 12 publications

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“…Head and neck cancers are responsible for only 1.5% of syndrome of inappropriate secretion of ADH (SIADH) [24] and a rare case report suggested that SIADH can be related to thyroid cancer [27]. In our univariate analysis, we found that lung metastasis had significant association with hyponatremia in moderate to severe group.…”

Section: Discussionmentioning

confidence: 66%

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

et al. 2014

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BackgroundDue to the alarming increase in the incidence of thyroid cancer worldwide, more patients are receiving postoperative radioactive iodine (RAI) therapy and these patients are given a low-iodine diet along with levothyroxine withdrawal to induce a hypothyroid state to maximize the uptake of RAI by thyroid tissues. Recently, the reported cases of patients suffering from life-threatening severe hyponatremia following postoperative RAI therapy have increased. This study aimed to systematically assess risk factors for developing hyponatremia following RAI therapy in post-thyroidectomy patients.MethodsWe reviewed the medical records of all thyroid cancer patients who underwent thyroidectomy and postoperative RAI therapy from July 2009 to February 2012. Demographic and biochemical parameters including serum sodium and thyroid function tests were assessed along with medication history.ResultsA total of 2229 patients (47.0±11.0 years, female 76.3%) were enrolled in the analysis. Three hundred seven patients (13.8%) of all patients developed hyponatremia; 44 patients (2.0%) developed moderate to severe hyponatremia (serum Na+≤130 mEq/L) and another 263 (11.8%) patients showed mild hyponatremia (130 mEq/L

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Section: Discussionmentioning

confidence: 66%

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

et al. 2014

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“…No correlation was found between lymphatic nodal status and the syndrome. 4–6,10,11 Our results indicate that the two parameters correlate, but without statistical proof ( P = .1231).…”

Section: Discussionmentioning

confidence: 62%

“…Previous studies have suggested a connection between disease recurrence and the syndrome 2,6,10,11 although no connection was statistically significant. 5 Our results did not show any correlation between disease recurrence and the syndrome.…”

Section: Discussionmentioning

confidence: 81%

Syndrome of Inappropriate Antidiuretic Hormone or Arginine Vasopressin Secretion in Patients Following Neck Dissection

et al. 2002

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SIADH following neck dissection may be less common than formerly reported. Previous studies have presented contradicting data concerning the influence of tumor recurrence or prior radiation therapy on its incidence. Our results indicate no such association. A statistically significant connection between smoking and the syndrome was found. No clinical symptoms developed in the patients with SIADH, but it seems prudent to suggest limiting fluid intake in the first postoperative 24 hours for patients following neck dissection.

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“…Although the prognosis of patients with paraneoplasti c syndromes associated with laryngeal cancer is poor (80), we believe that knowledge of these syndromes is important for diagnosis and treatment. In particular, water restriction and parenteral sodium chloride may be suf cient for overcoming the acute phase of the syndrome of inappropriate antidiuretic hormone secretion (81).…”

Section: Paraneoplastic Syndromesmentioning

confidence: 99%

The Future of Laryngology

Ferlito

Buckley²,

Ossoff³

et al. 2001

Acta Oto-Laryngologica

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Ferlito A, Buckley JG, Ossoff RH, Rinaldo A, Weir N. The future of laryngology. Acta Otolaryngol 2001; 121: 859 -867.Otorhinolaryngolog y has only been recognized as a single and distinct specialty since about 1920 (1). The specialty of otolayrngolog y is a product of the 20th century; otology and laryngology have quite different origins. The early otologists were surgeons used to the scalpel and trephine whilst the early laryngologists were physicians who combined their knowledge of the larynx with that of the chest. The link between the two, namely rhinology, was embraced by the laryngologists. The two separate disciplines had their own practitioners, departments and journals and only came together, with a few exceptions, in the middle of the rst half of the 20th century (2).This technological era is fast-moving and rapidly changing. Medicine must be updated and go where the ''world goes''. In the beginning otolaryngology was a specialty created from a fusion of the disciplines of otology and laryngology (2) and concerned the study and treatment of otological, rhinological, laryngological and pediatric otolaryngological diseases. However, the increasing knowledge and complexity of the subject lead this specialty to subdivide again over the last few decades. Within 5 years of completion of residency training, it is no longer possible in most cases to consider a general otolaryngologist to be a well-prepared and updated specialist in all elds of the specialty. We have seen increasing subspecialization in otolaryngology over the last few years. This has principally been into otology neurotology, rhinology, laryngology, head and neck surgery and pediatric otolaryngology . Within these areas some practitioners have developed further special expertise in the elds of otological and oncological skull base surgery, hearing and balance, facial plastic and reconstructive surgery and voice disorders. There is also a trend towards subspecialization in some aspects of otology (3).There still remains a need for the general otolaryngologist but there is also a place for suf cient subspecialists to serve a wider population's needs (2). Subspecialization is a natural progression of the accumulation of increasing knowledge that improves the technology and surgical techniques, as well as focusing on a clinical practice that is of bene t to both the specialty and the patient (4). The American Board of Otolaryngolog y (ABOto) has suggested that they would consider subspecialty certi cation in those situations in which there is already a well-established subspecialty (4). A certi cate that recognizes subspecialty training provides an obvious recognition of the additional training and expertise (4). The approval of a Certi cate of Added Quali cation (CAQ) in a subspecialty was granted by the ABOto in otology neurotology and pediatric otolaryngology . Approval has also been given for subspecialization in facial plastic surgery in conjunction with the American Board of Plastic Surgery (4). Specialization increases in the clinic as in th...

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Syndrome of Inappropriate Antidiuretic Hormone Secretion in Cancer of the Head and Neck

Cited by 28 publications

References 12 publications

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

Syndrome of Inappropriate Antidiuretic Hormone or Arginine Vasopressin Secretion in Patients Following Neck Dissection

The Future of Laryngology

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