Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in patients with limited stage small cell lung cancer

Serum level of arginine-vasopressin influences the prognosis of extensive-disease small-cell lung cancer

“…Hyponatremia, occasionally experienced in SCLC patients, has been previously reported to aVect the survival of SCLC marginally (Sagman et al 1991;Kawahara et al 1997). However, the correlation of SIADH with the prognosis of SCLC is controversial (Tai et al 2006;List et al 1986;Harper et al 1982). On the other hand, there are several cases whose serum-sodium level was normal despite elevation of serum AVP level , and a third of patients with SCLC developing hyponatremia had no AVP activity in their plasma (Kamoi et al 1987;Bliss Jr et al 1990;.…”

Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Mimicking Limbic Encephalitis

“…The syndrome of inappropriate antidiuretic hormone has been reported in conjunction with many types of cancer, most frequently in association with small cell lung carcinoma. [6][7][8] Because of the common linkage between LE, SIADH, and cancer, a thorough workup for malignancy needs to be initiated in any patient with subacute memory impairment, seizures, and hyponatremia. We discuss the case of a patient with this type of presentation who was ultimately found to have SIADH due to ectopic antidiuretic hormone (ADH) production by a neuroendocrine tumor with a Merkel cell carcinoma (MCC) immunophenotype.…”

Small Cell Gallbladder Carcinoma Complicated by Paraneoplastic Hyponatremia: A Case Report and Literature Review

“…Paraneoplastic hyponatremia is important to recognize and treat because it can lead to life-threatening neurological complications [4]. It is also associated with poorer prognosis [5], and recurrence of hyponatremia may herald a relapse of the disease [6]. Furthermore, hyponatremia may also complicate treatment as it may be aggravated by certain types of chemotherapy, such as in our patient's case.…”