Syndrome of Inappropriate ADH Secretion (SIADH) in Birth Asphyxia and its Comparison in Different Grades of Birth Asphyxia, Gestation &amp; Birth Weight

Gupta, Harish; Dalal, Poonam; Sethi, Gurmeet Kaur; Kumar, Aashish; Bajaj, Hanish; Locham, K K

doi:10.1177/0973217920130106

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Immediate aggressive treatment of these abnormalities could modify the entire outcome of the babies. 6 Insufficient data regarding syndrome of inappropriate antidiuretic hormone in neonates making it difficult to optimize fluid and electrolyte support and precise guidelines for fluid and electrolyte therapy in these neonates. Keeping this in mind and working under such circumstances this study is designated to evaluate the occurrence of syndrome of inappropriate antidiuretic hormone in different grades of perinatal asphyxia and its correlation to gestation and birth weight.…”

Section: Introductionmentioning

confidence: 99%

Syndrome of inappropriate antidiuretic hormone secretion in neonates with birth asphyxia at tertiary care centre

Gagandeep

Vidhya

2019

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Syndrome of inappropriate antidiuretic hormone is an important metabolic complication of perinatal asphyxia. This study aims to study the occurrence of syndrome of inappropriate antidiuretic hormone in different grades of perinatal asphyxia and to find out the correlation of syndrome of inappropriate antidiuretic hormone to gestational age and birth weight in birth asphyxiated babies.Methods: It was a hospital-based cohort study. 50 neonates with different grades of asphyxia were enrolled in the study and 50 controls were taken. Syndrome of inappropriate antidiuretic hormone was diagnosed based on calculated plasma osmolality, serum and urine sodium, urine specific gravity and analyzed with different grades of birth asphyxia and birthweight and gestation age.Results: The occurrence of SIADH in birth asphyxiated babies was 26% and none of the babies in control group developed SIADH. The occurrence was more in the severely asphyxiated babies (53.8%), followed by moderate (30.8%) and then mildly asphyxiated babies (15.4%). Hyponatremia was seen in 26% of birth asphyxiated babies and can be used as a marker of SIADH. In relation to gestation age and birth weight there was no statistically significant correlation between SIADH and different grades of asphyxia. Mortality was high among the neonates who developed SIADH.Conclusions: The occurrence of SIADH was 26% in asphyxiated neonates and high in severe asphyxia and gestation age and birth weight beard no significant co relation.

show abstract

Section: Introductionmentioning

confidence: 99%

Syndrome of inappropriate antidiuretic hormone secretion in neonates with birth asphyxia at tertiary care centre

Gagandeep

Vidhya

2019

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

Coagulation profiles and percentiles in neonates with hypoxic‐ischemic encephalopathy undergoing therapeutic hypothermia: A step toward more accurate transfusion thresholds

De Rose,

Maddaloni,

Ronci

et al. 2024

Pediatric Blood & Cancer

View full text Add to dashboard Cite

BackgroundIn the literature, there are no studies about the transfusion threshold for neonates with hypoxic‐ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). In order to facilitate accurate interpretation of coagulation results in these neonates, we aimed to generate specific reference intervals in this specific population.MethodsThis retrospective study included all HIE neonates admitted from 2014 to 2022 to undergo TH. All infants during TH underwent blood exams, including the coagulation profile. Our primary outcome was to assess the estimates of the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles for each parameter on admission (before transfusion). By the receiver operating characteristic (ROC) analysis, the area under the ROC curve (AUC) and the best cut‐off point were used to evaluate the ability of the prothrombin time expressed as international normalized ratio (PT‐INR) to predict the risk of any bleeding.ResultsA total of 143 infants were included in this study. On admission, the median fibrinogen value was 205 mg/dL, prothrombin time 18.6 seconds, PT‐INR 1.50, activated partial thromboplastin time 38.3 seconds, thrombin time 18.6 seconds, antithrombin 57.0%. The optimal cut‐off of PT‐INR in predicting the risk of any bleeding was greater than 1.84 (AUC .623, p = .024).ConclusionFor the first time, we proposed the percentiles of coagulation parameters in our cohort of neonates with HIE. Furthermore, we found that a PT‐INR greater than 1.84 can significantly predict the risk of any bleeding. Further studies are needed to determine if a restrictive versus a liberal transfusion approach can be equally safer for these high‐risk infants.

show abstract

Syndrome of Inappropriate ADH Secretion (SIADH) in Birth Asphyxia and its Comparison in Different Grades of Birth Asphyxia, Gestation & Birth Weight

Cited by 2 publications

References 0 publications

Syndrome of inappropriate antidiuretic hormone secretion in neonates with birth asphyxia at tertiary care centre

Syndrome of inappropriate antidiuretic hormone secretion in neonates with birth asphyxia at tertiary care centre

Coagulation profiles and percentiles in neonates with hypoxic‐ischemic encephalopathy undergoing therapeutic hypothermia: A step toward more accurate transfusion thresholds

Contact Info

Product

Resources

About