Syndrome of Hyperinfection with Strongyloides stercoralis

Igra-Siegman, Y; Kapila, Rajendra; Sen, Purnendu; Kaminski, Zigmund C.; Louria, Donald B.

doi:10.1093/clinids/3.3.397

Cited by 288 publications

(160 citation statements)

References 44 publications

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“…Eosinopenia, or at least absence of eosinophilia, is associated with most conditions in which immunodeficiency leads to S. stercoralis hyperinfection and consequently to high lethality 6,13 . On the other hand, patients with strongyloidiasis and hyper eosinophilia appear to survive longer 6,20 and may have few symptoms in spite of immune suppression 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Coinfection with HIV has also been implicated, although the views are somewhat conflicting and the accepted view is that there are no solid criteria to establish a relationship between HIV infection and HS 14,16 . The death rate from HS, particularly in the DS form, can be as high as 60-86% 7,13 . Although Ivermectin at one or two doses per day is the drug of choice for S. stercoralis infection, the dosing for HS or DS does not appear to have been worked out yet, as it has not for Thiabendazole, an effective drug, but with side effects, or Albendazole, a much less effective drug 14 .…”

Section: Introductionmentioning

confidence: 99%

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Hyperinfection by Strongyloides stercoralis probably associated with Rituximab in a patient with mantle cell lymphoma and hyper eosinophilia

Incani¹,

Hernández

González³

2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe first report to our knowledge, of hyperinfection by Strongyloides stercoralis (HS) and hypereosinophilia, associated to immune suppression by Rituximab (the only drug received for the last one year and 10 months), in a patient with mantle-cell lymphoma (MCL), is presented. The patient has a 3-year history of MCL, and developed two accesses of HS during 2008, including meningitis, pneumonia and presence of larvae of S. stercoralis in the lungs. We had a unique chance to look at cytotoxicity of filariform larvae in the expectoration after Ivermectin treatment, showing immobilization and death of larvae, associated with eosinophils attached to the cuticle of the parasite.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperinfection by Strongyloides stercoralis probably associated with Rituximab in a patient with mantle cell lymphoma and hyper eosinophilia

Incani¹,

Hernández

González³

2010

Rev. Inst. Med. trop. S. Paulo

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“…High percentage of eosinophils are compatible with hyperinfection syndrome. If all patients (compromised and non compromised) are considered, higher eosinophil counts (>8%) are associated with a better prognosis (6). In contrast, eosinopenia shows a poor prognosis in patients with strongyloidiasis (7).…”

Section: Discussionmentioning

confidence: 99%

Strongyloidiasis Associated with Nephrotic Syndrome.

Mori¹,

Konishi²,

K³

et al. 1998

Intern. Med.

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Wereport a nephrotic syndrome patient with eosinophilia who developed ileus, epigastralgia and malabsorption due to strongyloidiasis which became symptomatic by steroid therapy. The patient was then treated with thiabendazole and recovered. A percutaneous renal biopsy revealed minimal change nephrotic syndrome. This renal injury may be brought on by severe infection of Strongyloides stercoralis. It is important to rule out strongyloidiasis prior to corticosteroid therapy to patients from eosinophilia endemicareas. (Internal Medicine 37: 606-610, 1998)

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“…Another situation that has been well described in transplant patients, not related to transmission via the organ but related to prior infection of the recipient, is hyperinfestation syndrome (113,187,247,257,284,325,379,381,398). This is due to an accelerated autoinfection cycle almost always associated with immune suppression (especially suppression of T-lymphocyte activity).…”

Section: Infections Caused By Strongyloides Stercoralismentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Syndrome of Hyperinfection with Strongyloides stercoralis

Cited by 288 publications

References 44 publications

Hyperinfection by Strongyloides stercoralis probably associated with Rituximab in a patient with mantle cell lymphoma and hyper eosinophilia

Hyperinfection by Strongyloides stercoralis probably associated with Rituximab in a patient with mantle cell lymphoma and hyper eosinophilia

Strongyloidiasis Associated with Nephrotic Syndrome.

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

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