Syndrome de sevrage au cannabis dans une population de patients mono- et polydépendants (cannabis et opiacés)

Vorspan, Florence; Guillem, E; Bloch, Vanessa; Bellais, Laetitia; Sicot, Romain; Noble, Florence; Lépine, J; Gorelick, David A.

doi:10.1016/j.encep.2010.12.007

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Subjects with heroin dependence did not report more insomnia, not confirming a previous study in an opiate-dependent sample. 14,15 Feeling bored was the third most common withdrawal symptom (one third of subjects), consistent with the proportion (50%) in a previous study of subjects without psychiatric or substance use comorbidity. 11 This study has several limitations.…”

Section: Brief Reportssupporting

confidence: 86%

“…In our study, 42% of non–heroin-dependent and 39% of heroin-dependent subjects experienced at least 2 DSM-5 withdrawal symptoms. This is less than the proportion previously reported in an opioid-dependent population (62.5% to 65.1%) 15 and in adults without major psychiatric or substance abuse comorbidity (57.3%). 11 Thirty-three percent of participants without heroin dependence met DSM-5 criteria for a cannabis withdrawal syndrome, comparable to the 40.9% prevalence previously reported among adults without substance abuse or psychiatric comorbidity.…”

Section: Discussioncontrasting

confidence: 60%

“…We are aware of only one study that investigated cannabis withdrawal symptoms, in a sample of 99 cannabis-dependent outpatients with or without concomitant opiate dependence 14-15 . That study reported no difference, with one exception, between the two groups in average number of withdrawal symptoms reported or the frequency and duration of symptoms, but only evaluated 6 symptoms: decreased appetite or weight loss, irritability, nervousness or anxiety, anger or aggression, restlessness, and sleep disturbance.…”

Section: Introductionmentioning

confidence: 99%

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Cannabis Withdrawal in Patients with and without Opioid Dependence

et al. 2014

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Background Cannabis use is common among opioid-dependent individuals, but little is known about cannabis withdrawal in this population. Method Thirty inpatients (57% men) completed the Marijuana Quit Questionnaire (MJQQ) after completing acute heroin detoxification treatment in St. Petersburg, Russia. The MJQQ collected data on motivations for quitting, withdrawal symptoms, and coping strategies used to help maintain abstinence during their most “userious” (self-defined) quit attempt made without formal treatment outside a controlled environment. Results At the start of their quit attempt, 70% of participants smoked cannabis at least weekly (40% daily), averaging [SD] 2.73 [1.95] joints daily; 60% were heroin-dependent. Subjects with heroin dependence were significantly older at the start of their quit attempt (22.9 [3.6] years vs. 19.1 [2.9] years), were significantly less likely to report withdrawal irritability/anger/aggression (22% vs. 58%), restlessness (0% vs. 25%), or physical symptoms (6% vs. 33%), or to meet diagnostic criteria for DSM-5 cannabis withdrawal syndrome (6% vs. 33%), and had shorter duration of abstinence (29.6 [28.7] months vs. 73.7 [44.1] months) than those without heroin dependence. Conclusion Cannabis users with opioid dependence are less likely to experience cannabis withdrawal, suggesting that opiate use may prevent or mask the experience of cannabis withdrawal. Results should be considered preliminary due to small convenience sample and retrospective data.

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Section: Brief Reportssupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

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Cannabis Withdrawal in Patients with and without Opioid Dependence

et al. 2014

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At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities

Greenwald

Moses

Roehrs

2021

Translational Research

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Weighing the balance: how analgesics used in chronic pain influence sleep?

Bohra

Kaushik

Temple

et al. 2014

British Journal of Pain

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Pain and sleep share a bidirectional relationship, with each influencing the other. Several excellent reviews have explored this relationship. In this article, we revisit the evidence and explore existing research on this complex inter-relationship. The primary focus of the article is on the pharmacological treatment of chronic non-malignant pain and the main purpose is to review the effect of various pharmacological agents used in the management of chronic pain on sleep. This has not been comprehensively done before. We explore the clinical use of these agents, their impact on sleep architecture and sleep physiology, the mechanism of action on sleep parameters and sleep disorders associated with these agents. Pharmacological classes reviewed include antidepressants, opioid analgesics, anti-epileptics, cannabinoids and non-steroidal anti-inflammatory agents, drugs most commonly used to manage chronic pain. The objective is to help health professionals gain better insight into the complex effect that commonly used analgesics have on an individual's sleep and how this could impact on the effectiveness of the drug as an analgesic. We conclude that antidepressants have both positive and negative effects on sleep, so do opioids, but in the latter case the evidence shifts towards the counterproductive side. Some anticonvulsants are sleep sparing and non-steroidal anti-inflammatory drugs (NSAIDs) are sleep neutral. Cannabinoids remain an underexplored and researched group.

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Syndrome de sevrage au cannabis dans une population de patients mono- et polydépendants (cannabis et opiacés)

Cited by 4 publications

References 34 publications

Cannabis Withdrawal in Patients with and without Opioid Dependence

Cannabis Withdrawal in Patients with and without Opioid Dependence

At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities

Weighing the balance: how analgesics used in chronic pain influence sleep?

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