Syndrome de Gougerot-Sjögren primitif du sujet âgé: caractéristiques cliniques et immunologiques

Chebbi, Wafa; Salem, Wafa Ben; Klii, R.; Kessomtini, W.; Jerbi, Saïda; Sfar, M.H.

doi:10.11604/pamj.2015.20.8.5042

Cited by 7 publications

(11 citation statements)

References 15 publications

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“…Its prevalence increases with age with a variable rate according to the literature. Indeed, the frequency was 30% according to Haga and [12] and was higher with 6% to 20% in other studies [10] [18] [19]. SS predominates in women with a female/male sex ratio of 9/1 or more [10] [11] [18] [19].…”

Section: Discussionmentioning

confidence: 96%

“…In Senegal, a study in a rheumatology department reported 74 cases of connective tissue disease in the elderly in 5 years [5]. Several studies have been carried out on the particularities of RA in the elderly [6] [7] [8] [9] and other studies have concerned SS [10] [11] [12] and systemic lupus erythematosus in the elderly [13] [14] [15] [16] and often the aspects of these affections were compared with those of the adults [17] [18] [19]. Our present study aimed to determine the clinical and paraclinical characteristics of systemic autoimmune diseases in the elderly in internal medicine in Dakar.…”

Section: Introductionmentioning

confidence: 99%

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Connective Tissue Diseases on the Elderly Population in Dakar Hospital Setting

Cheikh¹,

Faye²,

Dia³

et al. 2022

OJIM

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Introduction: Immunosenescence contributes to the development of autoantibodies. However, while the prevalence of some autoantibodies increases with age, the incidence of connective tissue diseases decreases with age. This study aims to determine the clinical and paraclinical characteristics of connective tissue diseases in the elderly population. Materials and Methods: We conducted a retrospective and descriptive study, from March 2010 to March 2021, in the Internal Medicine Department of Aristide Le Dantec Hospital, including all the medical records of patients followed up for connective tissue disease and whose symptomatology began at an age greater than or equal to 65 years. Epidemiological, clinical, paraclinical, therapeutic and evolutionary data were collected from a pre-established survey form and then processed using SPSS software. Results: Overall, 22 cases were collected out of 275 seen on consultation. They involved 16 women and 6 men, aged between 65 and 85 years with a median of 70 years. The mean duration of the clinical picture was 15.7 months with extremes of 1 and 96 months. The clinical symptoms were joint pain in 21 patients associated with dry eye and mouth syndrome in seven cases and one patient underwent isolated dry eye and mouth syndrome. Joint involvement was deforming in 13 patients. Poor general condition was noted in 20 patients. Biology showed anemia in 14 patients, hyperleukocytosis (2 patients) and thrombocytosis (5 patients). The sedimentation rate (SR) was accelerated in 9 patients and the C-reactive protein (CRP) was positive in 12 patients. Immunology showed a positive Latex test (3 patients/6), Waaler-Rose reaction (8 patients/13), anti-cyclic citrullinated peptides (anti-CCP) antibodies (11 patients/11), anti-nuclear antibodies (2 patients/4). Anti-extractable nuclear antigens (anti-ENA) antibody testing in 4 patients showed positive

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Connective Tissue Diseases on the Elderly Population in Dakar Hospital Setting

Cheikh¹,

Faye²,

Dia³

et al. 2022

OJIM

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“…The most frequently involved organs were joints (85.0%), nervous system (28.3%), and lungs (23.3%). 23 In the second largest series from Morocco, the most frequently involved organs in the 57 patients with pSS were joints (87.7%), lungs (28.1%), and nervous system (17.5%), with 50 (87.7%) patients complaining of severe fatigue. Neither rates of glandular involvement nor findings on salivary gland biopsy or results of the Schirmer test were specified.…”

Section: Glandular Extraglandular and Autoantibody Featuresmentioning

confidence: 97%

“…13,17,18,[21][22][23]25,27 In the largest series, antinuclear antibodies, anti-Ro/SS antigen A (SSA), and anti-La/SS antigen B (SSB) antibodies were found in 42 (70%), 35 (58.3%), and 22 (36.7%) patients, respectively. 23 In the second largest series, anti-Ro/SSA and anti-La/SSB autoantibodies were reported in 44 (77.2%) and 46 (80.7%) patients, respectively. 17 In another Tunisian study involving 31 patients (20 pSS/11 sSS), 18 (69.3%) of 26 patients tested had both anti-Ro/ SSA and anti-La/SSB antibodies.…”

Section: Glandular Extraglandular and Autoantibody Featuresmentioning

confidence: 99%

Epidemiology of Sjögren Syndrome in Africa

et al. 2022

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Background:The epidemiology of Sjögren syndrome (SS) has been extensively studied in America, Europe, and Asia.Objective: To summarize available data on the epidemiology of SS in Africa. Methods: MEDLINE, EMBASE, and African Journals Online were searched from inception up to May 17, 2020, to identify relevant articles. Data gleaned from these reports have been summarized narratively in this review.Results: Twenty-one hospital-based studies were included. These studies reported 744 cases of SS. The mean age at diagnosis varied between 28 and 73.6 years, and the female proportion ranged from 83.3% to 100%. There was no population-based incidence or prevalence. Among people with autoimmune and other rheumatic conditions, the frequency of primary SS was in the range 1.9% to 47.6%, whereas that of rheumatoid arthritisassociated secondary SS was in the range 4.3% to 100%. Sicca symptoms were the commonest features, with most frequently involved organs being joints, lungs, and neurological structures. Main autoantibodies were anti-Ro/SS antigen A, anti-La/SS antigen B, and antinuclear antibodies. Conclusions:The epidemiology of SS is poorly characterized in Africa.Available data are broadly consistent with those from other populations. Extensive and high-quality research is urgently needed.

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“…EOpSS has an estimated overall prevalence of approximately 3%, but epidemiological data are very heterogeneous, depending on variables such as geographic area and diagnostic criteria. As an example, in an Italian cohort, 6% of patients had EOpSS [16], while in a Tunisian cohort this value was 30% [17].…”

Section: Introductionmentioning

confidence: 98%

Sweet’s Syndrome Following Therapy with Hydroxychloroquine in a Patient Affected with Elderly-Onset Primary Sjogren’s Syndrome

2019

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Sweet’s syndrome is an uncommon skin disease characterized by painful polymorphic lesions associated with fever and neutrophilia. When biopsied, these lesions reveal a diffuse infiltrate of mature neutrophils in the papillary dermis. Several drugs can induce Sweet’s syndrome (so-called drug-induced Sweet’s syndrome (DISS)) but reports of DISS associated with hydroxychloroquine (HCQ) are exceptionally limited. A 72-year-old Caucasian female patient with elderly-onset primary Sjogren’s syndrome (EOpSS) but low disease activity presented with an abrupt onset of painful nodular and papular erythematous skin lesions after two weeks of therapy with HCQ 400 mg. A histological examination revealed a diffuse infiltrate of mature neutrophils in the papillary dermis, without vasculitis. After therapy with 25 mg/day prednisone and HCQ withdrawal, the cutaneous manifestations disappeared. When prednisone was permanently discontinued, the primary Sjogren’s syndrome (pSS) manifestations worsened and therapy with HCQ 200 mg was reintroduced. In a few days, the same skin lesions reappeared. Withdrawal of HCQ and a new cycle of prednisone resulted in their permanent disappearance. We reported a case of DISS following therapy with HCQ in a female patient affected by EOpSS. According to a literature review, this is the first report of this association.

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Syndrome de Gougerot-Sjögren primitif du sujet âgé: caractéristiques cliniques et immunologiques

Cited by 7 publications

References 15 publications

Connective Tissue Diseases on the Elderly Population in Dakar Hospital Setting

Connective Tissue Diseases on the Elderly Population in Dakar Hospital Setting

Epidemiology of Sjögren Syndrome in Africa

Sweet’s Syndrome Following Therapy with Hydroxychloroquine in a Patient Affected with Elderly-Onset Primary Sjogren’s Syndrome

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