Syndrome de Cushing révélateur d’un carcinoïde pulmonaire

Chadli, A.; Alami, L.; Aziz, S. El; Lazghad, A.; Ghomari, H. El; Kafih, M.; Essodegui, Fatiha; Jabri, L.; Farouqi, A; Marouan, F.

doi:10.1016/s0003-4266(06)72595-1

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“…Dans prés de la moitié des cas, la tumeur est d'origine bronchique, viennent ensuite par ordre de fréquence décroissant les tumeurs thymiques, les carcinomes pancréatiques, les cancers médul-laires de la thyroïde, les phéochromocytomes. Dans 30 à 50 % des cas, la tumeur reste occulte [2][3][4][7][8][9][10][11].…”

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Syndrome de Cushing paranéoplasique : intérêt de la scintigraphie des récepteurs de la somatostatine

et al. 2015

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“…De plus, l'IRM déter-mine la taille de l'adénome, ses rapports avec les sinus caverneux et son caractère éventuellement invasif. Elle guide le chirurgien durant l'exploration, évitant une chirurgie agressive et ses complications [3,4,7,11,12].…”

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Syndrome de Cushing paranéoplasique : intérêt de la scintigraphie des récepteurs de la somatostatine

et al. 2015

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A ‘smart’ type of Cushing's syndrome

Razenberg

Elte²,

Rietveld³

et al. 2007

European Journal of Endocrinology

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Cushing's syndrome results from lengthy and inappropriate exposure to excessive concentrations of either endogenous or exogenous glucocorticoids. This case report describes a patient with a novel type of Cushing's syndrome due to the use of party drugs. A 35-year-old woman had gained 8 kg body weight in 5 months and complained of anxiety. She showed a Cushing-like appearance and mild hypertension (blood pressure, BP 150/95 mmHg). She reported daily use of increasing doses of g-hydroxybutyric acid (GHB), a popular party drug. ACTH plasma levels were in the upper normal range (41 ng/l), with normal plasma cortisol (0.36 mmol/l). She showed an abnormal overnight 1 mg dexamethasone suppression test (cortisol 0.38 mmol/l). The urinary excretion of free cortisol in 24 h was also increased (0.47 mmol/24 h). CT scanning of the abdomen showed normal adrenals. After stopping GHB intake she lost 7 kg body weight and her BP normalized (BP 135/80 mmHg). GHB is a popular party drug in the Netherlands, but it is also used as a narcotic and for the treatment of narcolepsy. We hypothesize that GHB may bind to the pituitary gland g-aminobutyric acid-B receptors leading to ACTH overproduction. European Journal of Endocrinology 157 779-781

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Syndrome de Cushing révélateur d’un carcinoïde pulmonaire

Cited by 2 publications

References 16 publications

Syndrome de Cushing paranéoplasique : intérêt de la scintigraphie des récepteurs de la somatostatine

Syndrome de Cushing paranéoplasique : intérêt de la scintigraphie des récepteurs de la somatostatine

A ‘smart’ type of Cushing's syndrome

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