Syndrome d'interruption de la tige pituitaire

Barbeau, C; Jouret, Béatrice; D, Gallegos; Sévely, A; Manelfe, C.; Oliver, Isabel; Pienkowski, Catherine; Tauber, MT; Rochiccioli, P

doi:10.1016/s0929-693x(97)89368-2

Cited by 28 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The children all suffered acute brain trauma associated with loss of consciousness and subdural haematoma and were diagnosed with multiple pituitary hormone deficiencies several years after the initial insult. Delay in the diagnosis of hypopituitarism has frequently been reported (28,30,32,35,36).…”

Section: Evidence For Abnormal Pituitary Function After Tbi In Childrmentioning

confidence: 99%

See 1 more Smart Citation

Hypopituitarism in childhood and adolescence following traumatic brain injury: the case for prospective endocrine investigation

et al. 2006

View full text Add to dashboard Cite

Pituitary dysfunction is now well recognised after traumatic brain injury (TBI) in adults; however, little except anecdotal evidence is known about this potential complication in childhood and adolescence. Histopathological evidence exists for both hypothalamic and pituitary damage, but few data specific to children have been published. We review the available paediatric data, which shows that after both mild and severe TBI, hypopituitarism may occur, with GH and gonadotrophin deficiencies appearing to be most common. Precocious puberty has also been documented. Road-traffic accidents, falls, sport and child abuse are the most common aetiological factors for paediatric TBI. There are no published data on the incidence or prevalence, neither within a population of children with TBI, of hypopituitarism, nor on its natural history or response to hormone replacement. We urge paediatric endocrinologists, in collaboration with adult endocrinologists, to perform formal prospective research studies in patients suffering from TBI to clarify these questions.

show abstract

Section: Evidence For Abnormal Pituitary Function After Tbi In Childrmentioning

confidence: 99%

“…In these patients, responses of pituitary hormones to gonadotrophin-releasing hormone or thyrotrophin-releasing hormone (TRH) or growth hormone-releasing hormone and elevated prolactin were demonstrated. Magnetic resonance imaging (MRI) also demonstrated pituitary stalk transaction in several cases (30,31,35).…”

Section: Characteristics Of Hypopituitarismmentioning

confidence: 99%

Hypopituitarism in childhood and adolescence following traumatic brain injury: the case for prospective endocrine investigation

et al. 2006

View full text Add to dashboard Cite

show abstract

“…If Barbeau (1998), Nagel (1997) Fujisawa et al (1997, Lo et al (2004), Kikuchi et al (1988), and Kaffel (2006) found a correlation between pituitary height and intensity and number of endocrine deficiencies, other authors, do not find it (Argyropoulou et al, 1992;Bozzola,1996;Leger et al, 2005).…”

Section: Discussionmentioning

confidence: 98%

“…When it is ectopic, other malformations of HH region are associated (Bereqszaszi et al, 1996;Pinto et al, 1997), while in the case where the post pituitary gland is in place, there are no abnormalities in general (Colombo et al, 1987;Barbeau et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Interruption Syndrome Pituitary Stalk: About 8O Cases

Fedala¹,

Chentli²,

Meskine³

et al. 2015

ijccr

View full text Add to dashboard Cite

Summary We report the study of 80 patients (65 M, 15 F) with Interruption Syndrome Pituitary Stalk. They had consulted for delay stature n: 65 and polyuropolydipsic syndrome n: 2. The mean age at diagnosis was 7±2.8 years. Delivery dystocia was noted in 18.7%. Neonatal hypoxia has been reported in 5%. The average size of patients was -.3±DS/M (Sempe). Micropenis ± cryptorchidism was present in 50%. Pituitary hypoplasia represents 91.2% of abnormality. The post pituitary gland is ectopic in 37.5%: infundibular place (90%) Tubercinerum (10%). In 3.7%, it is not found. The number of ectopic and unseen post pituitary gland is significantly higher (p<10-6) when the stalk is discontinued (n: 28). Than when pituitary gland is normally (n=3). When the post pituitary gland is ectopic or unseen (n: 37), malformations of HH are associated generally (81, 08%).Pituitary is more severely reduced when the post pituitary gland is ectopic or invisible and that the stalk is interrupted than when it is normal: 1.5mm±0.6 vs. 1.8±3 mm (p: 0.01).Hormonal assessment revealed IGH in 100%. It was associated with others pituitary deficiencies in 68.7%. Diabetes insipidus was found in 05 cases.Multiple pituitary deficiencies are more common when there are at least two malformations anomalies. Reassessment revealed other hormonal deficiencies in 22, 5% of patients with a mean of 05 years.The genetic study performed showed no molecular defect (PROP 1 PIT1, LHX3, LHX4, HESX1).

show abstract

“…A total of 20 patients ranging in age from 0.1 to 16 years were included in the retrospective analysis; the severity of head injuries varied from mild without loss of consciousness to severe (table 5) [23,24,25,26,27,28,29,30,31,32]. As expected, most injuries were the result of falls or traffic accidents; however, there were also documented cases of hypopituitarism following abuse (e.g., direct injury, shaking) and sports-related injuries (e.g., judo).…”

Section: Tbi-induced Hypopituitarism In Childhoodmentioning

confidence: 99%