Syndrome d’inflammation orbitaire idiopathique : à propos de 24 cas

Khochtali, Sana; Zayani, M.; Ksiaa, Imen; Meriem, I. Ben; Zaouali, Sonia; Jelliti, Béchir; Khairallah, Moncef

doi:10.1016/j.jfo.2017.09.013

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…OIP is slightly more prevalent in middle-aged females [ 62 ]. The presenting symptoms and signs of OIP may include orbital pain, swelling/mass, erythema, diplopia, proptosis, limited ocular motility, decreased vision, optic neuropathy, conjunctival congestion and ptosis [ 1 , 63 ]. OIP can be divided into the following categories according to different anatomical sites.…”

Section: Diagnosismentioning

confidence: 99%

Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment

Fang,

Shen,

Dai

et al. 2023

Eur J Med Res

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Orbital inflammatory pseudotumor (OIP) is a benign, non-specific inflammatory disorder that commonly occurs in middle-aged adults and is usually unilateral but can occur bilaterally. Its clinical manifestations have tremendous clinical heterogeneity and vary according to the site of infiltration and the degree of lesions, including orbital pain, swelling, diplopia, proptosis, restricted eye movement, and decreased visual acuity. Clinical features, Image characteristics and pathological examinations often need to be evaluated to confirm the diagnosis. Currently, there is no systematic research on the pathogenesis of OIP, which may be related to immunity or infection. The first-line treatment is glucocorticoids. Radiotherapy, immunosuppressants, and biologics can be considered for treatment-resistant, hormone-dependent, or intolerant patients. In this review, we aim to summarize and focus on new insights into OIP, including new diagnostic criteria, pathogenesis, and discoveries in new drugs and treatment strategies. In particular, we highlight the literature and find that T cell-mediated immune responses are closely related to the pathogenesis of OIP. Further exploration of the mechanism and signaling pathway of T cells in the immune process will help to identify their therapeutic targets and carry out targeted therapy to treat refractory OIP and reduce the side effects of traditional treatments.

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Section: Diagnosismentioning

confidence: 99%

Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment

Fang,

Shen,

Dai

et al. 2023

Eur J Med Res

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Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers

Jiang,

Xu,

Yao

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Clinical Characteristics of Idiopathic Orbital Inflammation Syndrome in Relation to Intraocular Pressure

Otsuka¹,

Yunoki²,

Ozaki³

et al. 2022

OPTH

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Purpose To investigate the clinical characteristics of idiopathic orbital inflammation and changes in intraocular pressure (IOP) before and after its treatment. Patients and Methods We retrospectively studied 20 eyes from the medical records of 19 patients who were diagnosed with idiopathic orbital inflammation between April 1, 2004, and April 30, 2019, at Toyama University Hospital. The inflammation site (type of disease), treatment provided, IOP before and after treatment, and the symptoms (proptosis, decreased ocular movements or diplopia, periorbital edema, and ocular pain) were analyzed. Results The types of idiopathic orbital inflammation were dacryoadenitis in 14, myositis in 7, diffuse-type in 3, and posterior periscleritis in 1 case. The mean IOP after treatment was 15.4±3.9 mm Hg, which was significantly lower than the mean pretreatment IOP of 19.0±5.3 mm Hg (p = 0.009). Before treatment, all cases with the diffuse-type had high IOPs of 21 mm Hg or more. Ocular pain and eye movement disorders were present in 86% and 100% of subjects in the group with an IOP of 21 mm Hg or higher, but 38% and 31% in the group with an IOP of 20 mm Hg or lower, respectively. Conclusion Diffuse-type of idiopathic orbital inflammation is prone to develop high IOP. Patients with idiopathic orbital inflammation and high IOP exhibit many symptoms such as decreased ocular movements, diplopia, and ocular pain.

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Syndrome d’inflammation orbitaire idiopathique : à propos de 24 cas

Cited by 4 publications

References 30 publications

Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment

Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment

Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers

Clinical Characteristics of Idiopathic Orbital Inflammation Syndrome in Relation to Intraocular Pressure

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