Syndrome d’activation macrophagique d’origine infectieuse : étiologies et prise en charge

Hemophagocytic syndrome in pregnancy: case report, diagnosis, treatment, and prognosis

“…Given the patient's medical history, HPS secondary to autoimmune disease seemed highly likely after excluding any infectious disease. Immune deficiency-related HPS is very common [4,6,[15][16][17][18][19] (45%). The most prevalent pathogens responsible for immune deficiency-related HPS were reported to be herpesviridae, in particular, CMV, EBV, and HSV.…”

Macrophage activation syndrome associated with co-trimoxazole

“…Moreover, the reported cases of MAS induced by pyogenic bacteria, especially Staphylococcus aureus, usually occurred 8 days (5-15 days) after the onset of infection [4][5][6][7], whereas for our patient, MAS occurred 24 days after the onset of infection. MAS secondary to bacterial infection has a poor prognosis without a specific treatment such as steroid or immunosuppressive drugs [1,2], with a mortality rate superior to 49 % [1]. In our patient, the outcome was favorable only by stopping co-trimoxazole.…”

“…Most cases of MAS are induced by infectious diseases, especially viral infections [1,2]. The clinical presentation of MAS secondary to bacterial infections is almost always associated with severe sepsis or septic shock [2][3][4][5][6][7]; this was not the case for our patient whose osteitis outcome was good.…”

“…The clinical presentation of MAS secondary to bacterial infections is almost always associated with severe sepsis or septic shock [2][3][4][5][6][7]; this was not the case for our patient whose osteitis outcome was good. Moreover, the reported cases of MAS induced by pyogenic bacteria, especially Staphylococcus aureus, usually occurred 8 days (5-15 days) after the onset of infection [4][5][6][7], whereas for our patient, MAS occurred 24 days after the onset of infection.…”

“…In adults, the hemophagocytic syndrome is usually a secondary event and is called Macrophage Activation Syndrome (MAS). MAS is a rare disease, with an underestimated incidence, due to the secretion of pro-inflammatory cytokines, leading to the phagocytosis of blood cells in bone marrow and lymphoid organs [1,2].…”