Syndrome Characterized by Osteitis Fibrosa Disseminata, Areas of Pigmentation and Endocrine Dysfunction, with Precocious Puberty in Females

Albright, Fuller; Butler, Allan M.; Hampton, Aubrey O.; Smith, P. E.

doi:10.1056/nejm193704292161701

Cited by 983 publications

(355 citation statements)

References 6 publications

(11 reference statements)

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“…The McCune-Albright syndrome (MAS) is characterized by a triad of physical signs: café-au-lait pigmented skin lesions, polyostotic fibrous dysplasia (FD), and endocrine dysfunction, which particularly manifests as peripheral precocious puberty in girls (1,2). Other hyperfunctional endocrinopathies have been reported such as pituitary adenomas secreting growth hormone and/or prolactin (3), hyperthyroidism (4), autonomous adrenal hyperplasia (5), and hypophosphatemic osteomalacia (6).…”

Section: Introductionmentioning

confidence: 99%

Searching for somatic mutations in McCune–Albright syndrome: a comparative study of the peptidic nucleic acid versus the nested PCR method based on 148 DNA samples

et al. 2006

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Background: Activating mutations of the Gsa gene (GNAS), which encodes for the a-subunit of the stimulatory G protein, have been identified in patients with McCune-Albright syndrome (MAS). Accuracy and sensitivity in the molecular diagnosis of MAS is mandatory for optimal therapeutic strategy and adapted follow-up, especially for incomplete clinical forms of MAS. To date, the highly sensitive nested PCR method with intermediary digestion by a restriction enzyme at the mutation site is one of the most widely used techniques. This study evaluated a new diagnostic method using a peptidic nucleic acid (PNA) and compared it with the nested PCR method. Material and methods: One hundred and forty-eight DNA samples from eighty-eight patients presenting clinical symptoms compatible with MAS were included. The DNA samples were mainly obtained from peripheral blood, ovarian tissue or cyst liquid, and bone lesions. The nested PCR method required 4 days. PNA clamping required 1.5 days and utilized the higher thermal stability and specificity of PNA-DNA coupling to inhibit PCR product formation. Direct sequencing was subsequently performed in all cases. Results: The sensitivity of mutation detection was 54% (nZ80) for nested PCR and 46.6% (nZ69) for PNA (PO0.05). The 11 cases where PNA failed to detect the mutation were mainly incomplete and atypical clinical forms of MAS (nZ10/11). The cost per sample was 50 euros for PNA clamping versus 136 euros for nested PCR. Conclusion: PNA clamping is a rapid, reliable, and economical method to diagnose MAS. It should be the first-line diagnostic method, although negative results, especially for incomplete clinical forms of MAS, should be confirmed by nested PCR.

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Section: Introductionmentioning

confidence: 99%

Searching for somatic mutations in McCune–Albright syndrome: a comparative study of the peptidic nucleic acid versus the nested PCR method based on 148 DNA samples

et al. 2006

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“…McCune-Albright syndrome is a sporadic disease characterized by polyostotic fibrous dysplasia, café-aux-lait lesions, and a variety of endocrine disorders (1,2). The molecular basis of this syndrome has recently been elucidated.…”

mentioning

confidence: 99%

Dynamics of Ovarian Function in an Adult Woman with McCune-Albright Syndrome

Laven¹,

Lumbroso²,

Sultan³

et al. 2001

Journal of Clinical Endocrinology & Metabolism

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“…This disorder also became the basis for the study of abnormal renal phosphate transport. Finally, in 1937, Albright reported five cases of another unusual bone disorder, polyostotic fibrous dysplasia, which was associated with hyperpigmented lesions of the skin and endocrine dysfunction (10). Today the disorder is called the McCune-Albright syndrome.…”

Section: Mineral Metabolismmentioning

confidence: 99%