Syndecan-4 Modulates Epithelial Gut Barrier Function and Epithelial Regeneration in Experimental Colitis

Fröhling, Mareike; Tepasse, P; Intemann, Johanna; Sambale, Meike; Sherwood, J.; Paruzel, Peter; Tiemeyer, Nina-Marie; Nowacki, Tobias M.; Brückner, Markus; Mennigen, Rudolf; Lügering, Andreas; Echtermeyer, Frank; Pap, Thomas; Stratis, Athanasios; Bettenworth, Dominik

doi:10.1093/ibd/izy248

Cited by 18 publications

(15 citation statements)

References 53 publications

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“…While primarily expressed in the colonic epithelium, syndecan-4 accumulated the deficiency during the growth of susceptibility regarding the intestinal inflammation. Mechanisms were proposed that syndecan-4 played a role in protecting against inflammation, keeping the epithelial gut barrier's unity and regeneration (64). When using anti-syndecan-4 antibodies as a therapeutic approach to treat patients with inflammatory disorders, researchers must carefully evaluate patients who have inflammatory diseases associated with an epithelial barrier function.…”

Section: The Role Of Pgs In Brain Inflammation and Plasticitymentioning

confidence: 99%

Proteoglycans as Therapeutic Targets in Brain Cancer

Yan¹,

Wang

2020

Front. Oncol.

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Proteoglycans (PGs) are heavily glycosylated diverse proteins consisting of a "core protein" covalently attached to glycosaminoglycans (GAGs) and present on the cell surface, extracellular matrix, and intracellular milieu. Extracellular proteoglycans play crucial roles in facilitating cell signaling and migration, interacting with growth factor receptors, intracellular enzymes, extracellular ligands, and matrix components, as well as structural proteins and promoting significant tumor-microenvironment interactions in cancerous settings. As a result of their highly regulated expression patterns, recent research has focused on the role of proteoglycans in the development of nervous tissue, such as their effect on neurite outgrowth, participation in the development of precursor cell types, and regulation of cell behaviors. The present review summarizes current progress for the studies of proteoglycan function in brain cancer and explains recent research involving brain glycoproteins as modulators of migration, cell adhesion, glial tumor invasion, and neurite outgrowth. Furthermore, we highlight the correlations between specific proteoglycan alterations and the suggested cancer-associated proteoglycans as novel biomarkers for therapeutic targets.

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Section: The Role Of Pgs In Brain Inflammation and Plasticitymentioning

confidence: 99%

Proteoglycans as Therapeutic Targets in Brain Cancer

Yan¹,

Wang

2020

Front. Oncol.

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“… 39 Another important function of GAG-PGs is the maintenance of the gut barrier function. 40 Membrane homeostasis is shown to be achieved by the modulation of epithelial regeneration through HSPGs 41 and HA. 42 The loss of barrier function is directly associated with the protein leaking enteropathy, 43 colitis, and IBD.…”

Section: Host Gags and The Hgm – Physiological Implicationsmentioning

confidence: 99%

“… 42 The loss of barrier function is directly associated with the protein leaking enteropathy, 43 colitis, and IBD. 41 , 44 …”

Section: Host Gags and The Hgm – Physiological Implicationsmentioning

confidence: 99%

Utilization of glycosaminoglycans by the human gut microbiota: participating bacteria and their enzymatic machineries

et al. 2022

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“…These either act directly on integrins or via the action of tertiary receptors. For references see [39,40,42,122,[194][195][196][197][198][199][200][201][202][203][204][205].…”

Section: Heparan Sulfate Proteoglycans In Fibrosismentioning

confidence: 99%

Syndecan receptors: pericellular regulators in development and inflammatory disease

et al. 2021

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The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in both vertebrates and invertebrates have shown that syndecans link to the actin cytoskeleton and can fine-tune cell adhesion, migration, junction formation, polarity and differentiation. Although often associated as co-receptors with other classes of receptors (e.g. integrins, growth factor and morphogen receptors), syndecans can nonetheless signal to the cytoplasm in discrete ways. Syndecan expression levels are upregulated in development, tissue repair and an array of human diseases, which has led to the increased appreciation that they may be important in pathogenesis not only as diagnostic or prognostic agents, but also as potential targets. Here, their functions in development and inflammatory diseases are summarized, including their potential roles as conduits for viral pathogen entry into cells.

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Syndecan-4 Modulates Epithelial Gut Barrier Function and Epithelial Regeneration in Experimental Colitis

Cited by 18 publications

References 53 publications

Proteoglycans as Therapeutic Targets in Brain Cancer

Proteoglycans as Therapeutic Targets in Brain Cancer

Utilization of glycosaminoglycans by the human gut microbiota: participating bacteria and their enzymatic machineries

Syndecan receptors: pericellular regulators in development and inflammatory disease

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