Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration
Zih-Yin Lai,
Chung-Chi Yang,
Po-Hsun Chen
et al.
Abstract:Background
The healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In contrast, zebrafish display a remarkable capacity for scar-free heart regeneration. Previous studies have revealed that syndecan-4 (SDC4) regulates inflammatory response and fibroblast activity following cardiac injury in higher vertebrates. However, whether and how Sdc4 regulates h… Show more
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