Syndecan-1 improves severe acute kidney injury prediction after pediatric cardiac surgery

Abstract

Postoperative plasma syndecan-1 is associated with subsequent severe acute kidney injury and poor outcomes among children undergoing cardiac surgery. It may be useful to identify patients who are at increased risk for acute kidney injury after cardiac surgery.

Endothelial Glycocalyx and Cardiac Surgery: Newer Insights

“…4 Postoperative syndecan-1 levels also have been linked to increased risk of acute kidney injury after pediatric cardiac surgery. 5 A wide variation in the preoperative levels and other relevant causes of elevation (ischemia reperfusion injury, etc) present peculiar impediments to a universal application of EG degradation products despite the above-mentioned associations. Thus, Nussbaum et al studied the alterations in EG thickness after infant cardiac surgery by estimating the perfused boundary region with the aid of sidestream dark field imaging to visualize the microcirculation.…”

Effects of Low Versus Standard Pressure Pneumoperitoneum on Renal Syndecan-1 Shedding and VEGF Receptor-2 Expression in Living-donor Nephrectomy: A Randomized Controlled Study

“…Elevated serum syndecan-1 has predicted AKI and mortality in patients with acute heart failure and in cardiac surgery. 8,9 Higher tubular epithelial syndecan-1 expression promotes tubular cell survival and repair, that is correlated with prolonged allograft survival in kidney transplant patients. 10 Activation of vascular endothelial growth factor (VEGF) binding to VEGF receptor-2 (VEGFR-2) has an important role in maintaining angiogenesis and microvasculature permeability.…”

“…10 Activation of vascular endothelial growth factor (VEGF) binding to VEGF receptor-2 (VEGFR-2) has an important role in maintaining angiogenesis and microvasculature permeability. 9 Overstimulation of VEGF-VEGFR-2 induces renal tubulointerstitial injury through altered endothelial proliferation, abnormal angiogenesis, and extracellular matrix deposition. 10 These findings indicate that the inhibition of syndecan-1 shedding and VEGF-VEGFR-2 stimulation are novel targets in preventing or managing AKI, since serum blood urea nitrogen (BUN), creatinine, and urine output are delayed signs of deteriorating kidney function.…”

Awake Thoracic Epidural Anesthesia in Transapical Transcatheter Aortic Valve Implantation

“…4 Postoperative syndecan-1 levels also have been linked to increased risk of acute kidney injury after pediatric cardiac surgery. 5 A wide variation in the preoperative levels and other relevant causes of elevation (ischemia reperfusion injury, etc) present peculiar impediments to a universal application of EG degradation products despite the above-mentioned associations. Thus, Nussbaum et al studied the alterations in EG thickness after infant cardiac surgery by estimating the perfused boundary region with the aid of sidestream dark field imaging to visualize the microcirculation.…”