Abstract:Syncope is a relatively common clinical syndrome that is a subset of a broader range of conditions that cause transient loss of consciousness (TLOC). Other TLOC conditions include seizures, concussions, and intoxications. However, despite frequent confusion in the medical literature, syncope is and should be clearly distinguished from those other causes of TLOC by virtue of its pathophysiology; specifically, syncope is the result of self-terminating inadequacy of global cerebral nutrient perfusion, while the o… Show more
“…In this sense, before requesting this test, it is important to survey the clinical history of the syncope episode. If there is the suspicion of cardiac or neurological cause, the specific investigation must be conducted 33 . Leman et al 16 .…”
“…In this sense, before requesting this test, it is important to survey the clinical history of the syncope episode. If there is the suspicion of cardiac or neurological cause, the specific investigation must be conducted 33 . Leman et al 16 .…”
“…Stiffness of the limbs and opisthotonus might occur, but are quite uncommon compared to generalised epileptic seizures. Tonic-clonic movements and rigidity of the limbs might occur during and after the episode (hypoxic convulsive syncope), which might be confounded with generalised tonic-clonic epileptic seizures (Ettinger, 1972, Folino, 2005, Jhanjee et al, 2006, Strickberger et al, 2006. In the latter, dogs experience tonic-clonic movements and contractions of the facial muscles, with loss of consciousness (Heaven et al, 2000).…”
Section: Signs That Animals Present During the Main Phase Of The Episodementioning
Generalised epileptic seizures and syncope are two syndromes with similar clinical manifestation and their differentiation can be quite challenging. The aim of this review is to use an evidence-based approach in differentiating these two syndromes through the comprehension of the pathophysiological mechanisms involved and their clinical signs. Both syndromes affect regions of the forebrain and consciousness level, although, different mechanisms are involved. Syncope is a paroxysmal event secondary to a short-term decrease in cerebral perfusion, oxygenation or essential nutrients delivery. Generalised epileptic seizure activity is defined as the clinical manifestation of transient paroxysmal disturbances in brain function secondary to an imbalance between excitatory and inhibitory neurotransmitters. Clinical criteria, including precipitating events, clinical signs preceding, during and following the episodes and event duration, can be used to differentiate the two syndromes. Although these criteria might be useful for the practitioner, definite conclusions should be precluded due to the lack of original research articles and weak evidence on this specific field.
Application:The review might be a useful tool for the general practitioner and clinical scientist as it will aid towards the differentiation of two syndromes, i.e. generalised epileptic seizures and syncope, with similar clinical presentation.
“…6 A common presenting problem in health care settings, syncope accounts for 1% of emergency department (ED) visits 7,8 and 1% to 3% of hospital admissions. 1,15 Position statements from other professional medical organizations [16][17][18][19] and excellent reviews 20,21 have also been published recently for the same purpose. [12][13][14] Recognizing the scope of the problem, professional medical societies such as the European Society of Cardiology (ESC) have published clinical guidelines to direct a more effective management strategy.…”
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