Syncope, falls and cobalamin deficiency in the old population

Skrabal, F.

doi:10.1007/s10286-004-0179-x

Cited by 13 publications

(12 citation statements)

References 22 publications

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“…Both peripheral and autonomic neuropathy develop in vitamin B 12 deficiency, and treatment improves autonomic nervous system functions more rapidly. 31 Other studies have demonstrated that the change of posture may lead to an abnormal cardiovascular response (orthostatic hypotension, POTS, syncope) in one-third of patients 32,33 and that CFS is most likely associated with sympathetic dysfunction. 34 There are also studies supporting the similarity of the autonomic dysfunctions observed in CFS and POTS.…”

Section: Discussionmentioning

confidence: 99%

Postural Orthostatic Tachycardia Syndrome (POTS) and Vitamin B12 Deficiency in Adolescents

et al. 2014

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OBJECTIVE: Vitamin B12 is involved in the production of adrenaline from noradrenaline. It is the cofactor involved in catecholamine degradation and plays a role in myelin synthesis. The current study aimed to investigate the association between vitamin B12 levels and postural orthostatic tachycardia syndrome (POTS) during adolescence when accelerated myelin synthesis increases the vitamin B12 need. METHODS: One hundred twenty-five patients (mean age 11.1 ± 2.3 years; 60% female) reporting short-term loss of consciousness and diagnosed with vasovagal syncope based on anamnesis with a normal distribution and 50 control subjects (mean age 10.94 ± 2.5 years, 62% female) were included in this study. Serum vitamin B12, folic acid, and ferritin levels were measured prospectively in addition to other tests. We defined vitamin B12 deficiency as a serum level <300 pg/mL.1–4 RESULTS: Vitamin B12 levels were significantly lower in the patient group compared with the control group (47.2% vs 18%, P < .001). In the patient group, children with the POTS pattern had significantly lower vitamin B12 levels compared with children without the POTS response (P = .03). CONCLUSIONS: Vitamin B12 deficiency in patients with POTS may lead to sympathetic nervous system baroreceptor dysfunction.

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Section: Discussionmentioning

confidence: 99%

Postural Orthostatic Tachycardia Syndrome (POTS) and Vitamin B12 Deficiency in Adolescents

et al. 2014

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“…Furthermore, we are aware of the limitations of impedance cardiography for assessing absolute values of stroke volume. However, we were interested in assessing relative changes of SI, for which impedance cardiography is apparently well-suited 7 14 17 20. We used impedance cardiography in ironmen earlier and were able to detect the postexercise cardiac dysfunction in that study,5 which was shown by echocardiography earlier 21.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, baroreceptor reflex sensitivity was automatically assessed using the sequence technique 12. All functions of the Task Force monitor6 8 and of its predecessor7 have been assessed previously and the instrument has already been used successfully in a number of clinical studies 5 13 – 17…”

Section: Methodsmentioning

confidence: 99%

Determinants of fast marathon performance: low basal sympathetic drive, enhanced postcompetition vasodilatation and preserved cardiac performance after competition

Gratze

Mayer²,

Luft³

et al. 2008

Br J Sports Med

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Fast performance in the marathon is associated with low sympathetic modulation of vasomotor tone, maintained stroke index postcompetition and enhanced exercise-induced vasodilatation. We postulate that maintaining a low level of sympathetic modulation to resistance vessels during the course of training may indicate its appropriateness, thus enabling fast performance by optimal postexercise vasodilatation and by prevention of postcompetition cardiac dysfunction. This will have to be tested in future longitudinal studies.

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“…Impedance cardiography: Derived hemodynamic parameters were computed from continuous BP and HR and the impedance signal (Skrabal, 2004). The impedance signal was acquired from a small constant sinusoidal alternating current passing through the thorax between an electrode placed around the neck and another placed at the lower end of the sternum.…”

Section: Data Collectionmentioning

confidence: 99%

Genome-Wide Linkage Analysis of Hemodynamic Parameters Under Mental and Physical Stress in Extended Omani Arab Pedigrees: The Oman Family Study

Hassan¹,

Jaju

Voruganti

et al. 2011

Twin Res Hum Genet

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Background:We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests.Methods:The Oman Family Study subjects (N= 1277) were recruited from five extended families of ~10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (s), using variance components decomposition-based methods implemented in SOLAR.Results:Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventricular ejection time (LVET), respectively. For △WCT, suggestive QTLs were detected for CO on chr11 (LOD = 2.5), LVET on chr3 (LOD = 2.0) and EDI on chr9 (LOD = 2.1). For CPT, suggestive QTLs for HR and LVET shared the same region on chr22 (LOD 2.3 and 2.8, respectively) and on chr9 (LOD = 2.3) for SBP, chr7 (LOD = 2.4) for SV and chr19 (LOD = 2.6) for CO. For △CPT, CO and TPR top signals were detected on chr15 and 10 (LOD; 2.40, 2.08) respectively. Conclusion: Mental stress revealed the largest number of significant and suggestive loci for normal BP reported to date. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis of essential hypertension.

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Syncope, falls and cobalamin deficiency in the old population

Cited by 13 publications

References 22 publications

Postural Orthostatic Tachycardia Syndrome (POTS) and Vitamin B12 Deficiency in Adolescents

Postural Orthostatic Tachycardia Syndrome (POTS) and Vitamin B12 Deficiency in Adolescents

Determinants of fast marathon performance: low basal sympathetic drive, enhanced postcompetition vasodilatation and preserved cardiac performance after competition

Genome-Wide Linkage Analysis of Hemodynamic Parameters Under Mental and Physical Stress in Extended Omani Arab Pedigrees: The Oman Family Study

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