Syncope as an Initial Manifestation of Atypical Lipomatous Hypertrophy of the Interatrial Septum

Sheikh, Mujeeb; Hasan, Syed Shahzad; Kanjwal, Yousuf; Schwann, Thomas A.; Grubb, Blair P.

doi:10.1111/j.1540-8191.2012.01465.x

Cited by 5 publications

(20 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, LHIS can present with arrhythmias, caval obstruction, or even congestive heart failure. In symptomatic cases surgical treatment can be considered …”

Section: Discussionmentioning

confidence: 99%

“…Lipomatous hypertrophy of the interatrial septum (LHIS) is a relatively rare but well‐defined entity, consisting of a non‐capsulated deposition of fat within the atrial septum . Most of the patients with LHIS are asymptomatic and the condition is found incidentally, although some patients can present with supraventricular rhythm disturbances or heart block, which can result in sudden death . Differentiation from a malignant neoplasm can represent a diagnostic challenge.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Septectomy and biatrial resection for extensive septal lipomatosis

Sef¹,

Turina

2016

J Card Surg

View full text Add to dashboard Cite

show abstract

“…However, LHIS can present with arrhythmias, caval obstruction, or even congestive heart failure. In symptomatic cases surgical treatment can be considered …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Septectomy and biatrial resection for extensive septal lipomatosis

Sef¹,

Turina

2016

J Card Surg

View full text Add to dashboard Cite

show abstract

“…Although it is regarded as an incidental finding, only a few patients with obstructive physiology or intractable arrhythmias requiring surgery have been reported [Christiansen et al, 2000; Zeebregts et al, 1997]. Histologically, LHIS is made up of mature fat cells interspersed with hypertrophic cardiomyocytes [Cale et al, 2009; Sheikh et al, 2012]. Physiologic myocardial fat has also been seen during CT scans of asymptomatic subjects, most commonly along the right ventricular outflow tract and free wall, and on histology, it is typically seen in perivascular areas [Kimura and others 2010].…”

Section: Discussionmentioning

confidence: 99%

Myocardial fat overgrowth in Proteus syndrome

Hannoush

Sachdev

Brofferio

et al. 2014

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Proteus syndrome is a rare, mosaic disorder with asymmetric and distorting overgrowth of the skeletal system, skin, and adipose tissues. Cardiac abnormalities are rare in this syndrome and only two prior cases have been reported. Many patients with PS followed at our institution underwent transthoracic echocardiograms for preoperative evaluation or as work-up for associated pulmonary disease. Some were noted to have prominent, focal echodense areas in the myocardium. We further investigated cardiac findings in a cohort of children and adult patients with PS. Patients with abnormal echocardiograms were referred for cardiac magnetic resonance imaging, Holter monitoring, and exercise treadmill testing. Twenty children and adults with PS, age 24 months to 50 years old, underwent transthoracic echocardiograms. Seven patients (35%) had focal bright echodense areas within the myocardium suggesting fatty infiltration. The majority of patients had significant involvement of the interventricular septum. The cardiac characteristics of all patients with fatty infiltration on transthoracic echocardiograms were compared to Proteus patients without these findings. There were no significant differences in chamber sizes, mass, systolic or diastolic function. No increased risk of conduction defects or arrhythmias was found. This study shows that abnormal fat overgrowth is a common finding in the myocardium in patients with Proteus syndrome; however, it is not associated with functional derangements or arrhythmias. Further evaluation of a larger number of Proteus patients is needed in order to determine the frequency and prognosis of cardiac involvement.

show abstract

“…LHIS is a rare, benign lesion (incidence 1.1–2.2%) that is usually asymptomatic, and the diagnosis is incidentally made during imaging or at autopsy . Interatrial septal thickening can occur on either side of the septum with the greatest thickness usually superior to and sparing the fossa ovalis . Criteria for diagnosing LHIS includes septal thickness between 15 and 20 mm (more commonly 20 mm) although the septal thickness range is highly variable and has been observed up to 150 mm .…”

Section: Subtypes Of Pseudotumorsmentioning

confidence: 99%

“…Criteria for diagnosing LHIS includes septal thickness between 15 and 20 mm (more commonly 20 mm) although the septal thickness range is highly variable and has been observed up to 150 mm . LHIS occurs in the age range of 22–91 years (average age at diagnosis of 70 years old) . LHIS has an association with obesity and has a higher incidence in women .…”

Section: Subtypes Of Pseudotumorsmentioning

confidence: 99%

Intrinsic and Extrinsic Cardiac Pseudotumors: Echocardiographic Evaluation and Review of the Literature

et al. 2015

View full text Add to dashboard Cite

Echocardiography is the most common imaging modality for the assessment of cardiovascular tumors, followed by more advanced imaging modalities, such as cardiac computed tomography or cardiac magnetic resonance imaging. Non-neoplastic lesions that may simulate a true neoplasm on imaging are termed "cardiac pseudotumors." As echocardiography is the initial imaging modality where pseudotumors are identified, it is imperative to have a fundamental understanding of pseudotumors evaluation using echocardiography. There is paucity of the literature describing the different kinds of pseudotumors. This review is an attempt to describe common cardiac pseudotumors and to classify them based on their origin. The tumors arising from cardiac structures, such as epicardium, endocardium, or myocardium, were termed as "intrinsic" while the pseudotumors with no cardiac origin were termed as "extrinsic." The more common pseudotumors are described in detail with pertinent echocardiographic features and examples.

show abstract

Syncope as an Initial Manifestation of Atypical Lipomatous Hypertrophy of the Interatrial Septum

Cited by 5 publications

References 15 publications

Septectomy and biatrial resection for extensive septal lipomatosis

Septectomy and biatrial resection for extensive septal lipomatosis

Myocardial fat overgrowth in Proteus syndrome

Intrinsic and Extrinsic Cardiac Pseudotumors: Echocardiographic Evaluation and Review of the Literature

Contact Info

Product

Resources

About