Synchrotron Radiation-Induced Formation and Reactions of Free Radicals in Human Acellular Dermal Matrix

Gouk, Sok-Siam; Kocherginsky, N.M.; Kostetski, Yu.; Moser, H. O.; Yang, Ping; Lim, Teck Guan; Sun, Wendell Q.

doi:10.1667/rr3351

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…They were mainly retrospective cohort studies, in which the observation period ranged between the years 2001 and 2012. With the exception of two works, performed in UK [8] and Canada [7], one study reported the results obtained in a private practice in USA [28] and the others were done in departments of hospitals and universities in the USA. Sixteen percent of reconstructions were irradiated before, after, or before and after surgery; in these cases the rate of development for complications was 33%.…”

Section: Resultsmentioning

confidence: 99%

“…They are generally protein derivatives, mainly composed of collagen, to which elastin, proteoglycans, and glycosaminoglycans may be added. The impact with ionizing radiation to sterilize the dried form of Alloderm affected the 3D structure of the collagen matrix, and different species of free radicals developed [28, 30, 31]. An unsolved issue is how the modalities of irradiation could be modified to reduce the impact on the skin and on the implant.…”

Section: Discussionmentioning

confidence: 99%

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Acellular Dermal Matrices and Radiotherapy in Breast Reconstruction: A Systematic Review and Meta-Analysis of the Literature

Valdatta

Cattaneo

Pellegatta³

et al. 2014

Plastic Surgery International

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The increasing use of commercially available acellular dermis matrices for postmastectomy breast reconstruction seems to have simplified the surgical procedure and enhanced the outcome. These materials, generally considered to be highly safe or with only minor contraindications due to the necessary manipulation in preparatory phases, allow an easier one-phase surgical procedure, in comparison with autologous flaps, offering a high patient satisfaction. Unfortunately, the claim for a higher rate of complications associated with irradiation at the implant site, especially when the radiation therapy was given before the reconstructive surgery, suggested a careful behaviour when this technique is preferred. However, this hypothesis was never submitted to a crucial test, and data supporting it are often discordant or incomplete. To provide a comprehensive analysis of the field, we searched and systematically reviewed papers published after year 2005 and registered clinical trials. On the basis of a meta-analysis of data, we conclude that the negative effect of the radiotherapy on the breast reconstruction seems to be evident even in the case of acellular dermis matrices aided surgery. However, more trials are needed to make solid conclusions and clarify the poor comprehension of all the factors negatively influencing outcome.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acellular Dermal Matrices and Radiotherapy in Breast Reconstruction: A Systematic Review and Meta-Analysis of the Literature

Valdatta

Cattaneo

Pellegatta³

et al. 2014

Plastic Surgery International

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“…The benefit of cold gamma irradiation is therefore often attributed to the low mobility and reactivity of free radicals at −80°C. In an earlier study, we investigated the formation and reactions of free radicals in AlloDerm upon irradiation 32. Free radicals formed within AlloDerm upon irradiation were stable at temperatures below T g .…”

Section: Discussionmentioning

confidence: 99%

Alterations of human acellular tissue matrix by gamma irradiation: Histology, biomechanical property, stability, in vitro cell repopulation, and remodeling

et al. 2007

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AlloDerm, a processed acellular human tissue matrix, is used in a number of surgical applications for tissue repair and regeneration. In the present work, AlloDerm serves as a model system for studying gamma radiation-induced changes in tissue structure and stability as well as the effect of such changes on the cell-matrix interactions, including cell repopulation and matrix remodeling. AlloDerm tissue matrix was treated with 2-30 kGy gamma irradiation at room temperature. Gamma irradiation reduced the swelling of tissue matrix upon rehydration and caused significant structural modifications, including collagen condensation and hole formation in collagen fibres. The tensile strength of AlloDerm increased at low gamma dose but decreased with increasing gamma dosage. The elasticity of irradiated AlloDerm was reduced significantly. Calorimetric study showed that gamma irradiation destabilized the tissue matrix, resulting in greater susceptibility to proteolytic enzyme degradation. Although gamma irradiation did not affect in vitro proliferation of fibroblast cells, it promoted tissue degradation upon cell repopulation and influenced synthesis and deposition of new collagen.

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“…27 The diffusion model described the radical reaction kinetics in terms of fast free radical decay on the fibre surface and a diffusion-limited slow decay of radicals formed inside the fibre. The dispersive model considered the molecular mobility and dispersivity of free radicals in a heterogeneous material, but only as a first-order decay process.…”

Section: Diffusion-controlled Model For Picl Decaymentioning

confidence: 99%

Kinetics of Photo-Induced Chemiluminescence Decay from Polymers

Millington

Maurdev

2009

Polym. J.

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Previous studies showed that the decay of photo-induced chemiluminescence (PICL) in polymers does not obey classical first or second order kinetics. This study demonstrates that plotting PICL second-order decay from three fibrous polymers (polypropylene, polyamide 6 and wool keratin) in a modified form gives excellent linear plots. The existence of a significantly less reactive fraction of macroperoxy radicals in heterogeneous polymers can explain the deviation from classical behaviour and this fraction can be quantified from the gradient of the modified plots. This unreactive fraction could be due to either dispersive or diffusive effects in a disordered heterogeneous polymer medium. Both dispersive and diffusive models give very good fits to the PICL decay profiles using three fitting parameters.

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Synchrotron Radiation-Induced Formation and Reactions of Free Radicals in Human Acellular Dermal Matrix

Cited by 12 publications

References 21 publications

Acellular Dermal Matrices and Radiotherapy in Breast Reconstruction: A Systematic Review and Meta-Analysis of the Literature

Acellular Dermal Matrices and Radiotherapy in Breast Reconstruction: A Systematic Review and Meta-Analysis of the Literature

Alterations of human acellular tissue matrix by gamma irradiation: Histology, biomechanical property, stability, in vitro cell repopulation, and remodeling

Kinetics of Photo-Induced Chemiluminescence Decay from Polymers

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