Synchrotron radiation in radiology: radiology techniques based on synchrotron sources

Meuli, Reto; Hwu, Y.; Je, Jung Ho; Margaritondo, G.

doi:10.1007/s00330-004-2361-x

Cited by 62 publications

(63 citation statements)

References 28 publications

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“…[3][4][5] In essence, SR produces superior image quality because, first, the extremely high intensity of radiation emitted from the synchrotron storage ring produces extremely bright light. This allows greater X-ray penetration of thick tissues, greater image contrast, and greater X-ray flux during short exposure time to produce sharp and blur-free images.…”

Section: Sr Microangiographymentioning

confidence: 99%

“…3,4 Phase-contrast X-ray imaging makes use of the phase shift and the associated change in the propagation direction of the X-rays. Because SR provides X-rays with a well-defined phase, it is feasible to measure and use phase changes in imaging, and even to exploit these properties.…”

Section: Other Sr Techniques and Simultaneous Multi-sr Imaging Approamentioning

confidence: 99%

“…The principles of SR generation and imaging techniques from a physics perspective are presented in previous reviews. [2][3][4] A comparison of SR angiography approaches for small-and large-area imaging is briefly described here but is considered in detail elsewhere with consideration of radiation skin entry dosage. 5 …”

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confidence: 99%

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Synchrotron Radiation Imaging for Advancing Our Understanding of Cardiovascular Function

Shirai

Schwenke

Tsuchimochi

et al. 2013

Circulation Research

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Synchrotron radiation (SR) is increasingly being used for micro-level and nano-level functionalimaging in in vivo animal experiments. This review focuses on the methodology that enables repeated and regional assessment of vessel internal diameter and flow in the resistance vessels of different organ systems. In particular, SR absorption microangiography approaches offer unique opportunities for real-time in vivo vascular imaging in small animals, even during dynamic motion of the heart and lungs. We also describe recent progress in the translation of multiple phase-contrast imaging techniques from ex vivo to in vivo smallanimal studies. Furthermore, we also review the utility of SR for multiple pinpoint (dimensions 0.2×0.2 mm) assessments of myocardial function at the cross-bridge level in different regions of the heart using small-angle X-ray scattering, resulting from increases in SR flux at modern facilities. Finally, we present cases for the use of complementary SR approaches to study cardiovascular function, particularly the pathological changes associated with disease using small-animal models. -times brighter than laboratory or medical X-ray sources). This brightness is attributable to the fine collimation of the X-ray beam (http:// www.spring8.or.jp/en/about_us/whats_sr/generation_sr/).At SPring-8 in Japan, which is one of the largest SR facilities in the world, one of the smallest beam sizes is ≈2 mm horizontally by 0.4 mm vertically at 40 m from the X-ray source. This divergence is much smaller than that of most laboratory lasers. The X-ray beam is further collimated with focusing optics, so that it is <0.2 mm in diameter at the sample, concentrating a large number of X-ray photons on the sample. There are tens of SR facilities around the world, most of which are available for public access (for details on SR facilities, SR characteristics, and other science applications, http://www.lightsources.org/cms/).The intense X-ray beam from the synchrotron beamlines only can be used in metal-shielded hutches. X-ray image formation and acquisition have to be performed under remote control, including operations to inject contrast medium into an animal or to stop artificial ventilation temporarily. Despite this restriction, when the animal is closely monitored, the experiment can be performed smoothly. At SR medical imaging beamlines important infrastructure for animal experiments such as an animal house, and biology and chemistry preparation laboratories are an essential capability for the experiments described in this review. SR Absorption MicroangiographyThe vascular smooth muscle tone of arterioles is meticulously modulated via multiple mechanistic pathways, including, but not limited to, the vessel endothelium, the vascular smooth muscle, and neurohumoral stimuli to regulate resistance to flow and, hence, to optimize regional blood flow. Impairment of any of these regulatory systems has the potential to adversely impact on the vascular control of blood flow and, thus, impair the homeostatic control...

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Section: Sr Microangiographymentioning

confidence: 99%

Section: Other Sr Techniques and Simultaneous Multi-sr Imaging Approamentioning

confidence: 99%

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Synchrotron Radiation Imaging for Advancing Our Understanding of Cardiovascular Function

Shirai

Schwenke

Tsuchimochi

et al. 2013

Circulation Research

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“…Applying new techniques for the detection of fibrosis may potentially circumvent the pitfalls and deficiencies of the existing surrogates mentioned above. These include serum proteomics, glycomics and new imaging techniques such as molecular imaging technique for the imaging of cellular biochemical processes 82 , diffraction-enhanced imaging technique for the imaging of soft tissues 83 , photonic imaging technique for three-dimensional whole-body images 84 . However, further studies are needed to develop or validate noninvasive tests that can accurately reflect the full spectrum of hepatic fibrosis in CLDs.…”

Section: Resultsmentioning

confidence: 99%

Noninvasive Alternatives for the Assessment of Liver Fibrosis

Lu¹,

Zhou²

2011

Liver Biopsy

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“…X-ray SR sources revolutionized biological imaging. Several techniques exploiting phase contrast (PC), including X-ray interferometry, diffraction-enhanced imaging, and in-line PC radiography benefit particularly well of characteristic properties of synchrotron beams [1]. Phase contrast, due to its sensitivity, up to 10 3 times higher in the range of photon energies between 15 and 35 keV, as compared to absorption contrast, can be monitored by SR even in cases, when absorption differences are extremely small [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Bioimaging with 4th Generation X-Ray Sources

Pełka

2009

Acta Phys. Pol. A

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Newly constructed 4th generation sources of intense synchrotron radiation in ultrafast pulses of only 10-50 fs and wavelengths up to X-rays, the free electron lasers, are expected to revolutionize development of biological science. To take full advantage of unique properties of the sources, new imaging techniques of molecular and microscopic biological objects are developed. Present article provides a short review of a stormy development of bioimaging with incoming soon 4th generation synchrotron radiation X-ray sources. Some implications for the future of new sources and techniques are discussed as well.

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Synchrotron radiation in radiology: radiology techniques based on synchrotron sources

Cited by 62 publications

References 28 publications

Synchrotron Radiation Imaging for Advancing Our Understanding of Cardiovascular Function

Synchrotron Radiation Imaging for Advancing Our Understanding of Cardiovascular Function

Noninvasive Alternatives for the Assessment of Liver Fibrosis

Bioimaging with 4th Generation X-Ray Sources

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