Synchrotron radiation-based coronary angiography

Rubenstein, Edward; Zeman, Herbert; Thompson, C.; Thomlinson, W.; Otis, J. N.; Kernoff, Robert S.; Hughes, Emlyn; Hofstadter, R.; Harrison, Donald C.; Gordon, H.J.; Giacomini, J.C.; Brown, G. S.

doi:10.1364/cleo.1986.tuf4

Cited by 6 publications

(6 citation statements)

References 2 publications

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“…Literature dating as far back as 1947 and in the 1950 ′ s [60][61][62] discuss the use of monochromatic Xrays. In later part of twentieth century, the focus shifted to exploring the potential of monochromatic X-rays obtained from synchrotrons [63,64]. In 1987, studies using monochromatic X rays from 20 to 100 keV showed that in the energy range of approximately 20-30 keV, cancerous breast tissues exhibit a higher attenuation than normal tissues [65].…”

Section: Past Studies That Demonstrated Advantages Of Monochromatic X-raysmentioning

confidence: 99%

Monochromatic X-rays: The future of breast imaging

Fishman

Rehani

2021

European Journal of Radiology

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To present details about the innovative and disruptive technology of monochromatic X-rays and its application to breast imaging. Methods: To analyze results of studies done using a prototype system for breast imaging that generates monochromatic X-rays through fluorescence emission. To assess signal-to-noise ratio (SNR) as a measure of image quality at different doses in breast phantoms of different sizes and review the comparison of parameters with a standard mammography system. Results: Monochromatic X-rays reduce the radiation dose per mammogram by a factor of 5 to 10 times. For phantom simulating thick breast (9 cm), the SNR for monochromatic system was 2.6 times higher and the dose 4.2 times lower than the respective values obtained with the conventional system within the same 5 mm × 5 mm square area of the 100% glandular step wedge. For the conventional broadband system to equal the SNR of the monochromatic system, it would require a dose of 19 mGy, 29 times higher than the dose delivered by the monochromatic system. Contrast-enhanced digital mammography with monochromatic X-rays is shown to provide a simpler and more effective technique at substantially lower radiation dose. Conclusions: Lowering radiation dose by a factor of 5 to 10 while maintaining image quality implies a major reduction in total exposure from breast cancer screening and dramatically less risk of radiation-induced cancers in at-risk women. The high SNRs for very thick breast phantoms provide strong evidence that screening with lower breast compression is possible while maintaining image quality.

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Section: Past Studies That Demonstrated Advantages Of Monochromatic X-raysmentioning

confidence: 99%

Monochromatic X-rays: The future of breast imaging

Fishman

Rehani

2021

European Journal of Radiology

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“…His idea was to take advantage of the differences in absorption of two or more monochromatic X-ray beams to produce an image only showing these differences and/or the concentration of an element in an object. The first studies of KES were performed by Rubenstein et al [34,35] at the Stanford Synchrotron Radiation Laboratory demonstrating the feasibility of coronary angiography. The first in vivo KES images were made of the coronary arteries of an anesthetized dog [36].…”

Section: History Of K-edge Subtraction Imaging At Synchrotron Sourcesmentioning

confidence: 99%

Spectroscopic imaging at compact inverse Compton X-ray sources

et al. 2020

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While K-edge subtraction (KES) imaging is a commonly applied technique at synchrotron sources, the application of this imaging method in clinical imaging is limited although results have shown its superiority to conventional clinical subtraction imaging. Over the past decades, compact synchrotron X-ray sources, based on inverse Compton scattering, have been developed to fill the gap between conventional X-ray tubes and synchrotron facilities. These so called inverse Compton sources (ICSs) provide a tunable, quasi-monochromatic X-ray beam in a laboratory setting with reduced spatial and financial requirements. This allows for the transfer of imaging techniques that have been limited to synchrotrons until now, like KES imaging, into a laboratory environment. This review article presents the first studies that have successfully performed KES at ICSs. These have shown that KES provides improved image quality in comparison to conventional X-ray imaging. The results indicate that medical imaging could benefit from monochromatic imaging and KES techniques. Currently, the clinical application of KES is limited by the low K-edge energy of available iodine contrast agents. However, several ICSs are under development or already in commissioning which will provide monochromatic X-ray beams with higher X-ray energies and will enable KES using high-Z elements as contrast media. With these developments, KES at an ICS has the ability to become an important tool in pre-clinical research and potentially advancing existing clinical imaging techniques.

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“…However, as highly brilliant X-rays are required for this imaging method, it has been limited to synchrotron facilities so far. Rubenstein et al [6,7] were the first to describe a dual-energy subtraction technique using synchrotron radiation, imaging coronary arteries around the K-edge of iodine. Elleaume et al [8] showed that it is possible to acquire high quality images at a synchrotron for coronary angiography in patients after intravenous injection of iodine contrast agent.…”

Section: Introductionmentioning

confidence: 99%

K-edge subtraction imaging for coronary angiography with a compact synchrotron X-ray source

et al. 2018

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About one third of all deaths worldwide can be traced back to cardiovascular diseases. An interventional radiology procedure for their diagnosis is Digital Subtraction Angiography (DSA). An alternative to DSA is K-Edge subtraction (KES) imaging, which has been shown to be advantageous for moving organs and eliminating image artifacts caused by patient movement. As highly brilliant, monochromatic X-rays are required for this method, it has been limited to synchrotron facilities so far, restraining the feasibility in clinical routine. Compact synchrotron X-ray sources based on inverse Compton scattering, which have been evolving substantially over the past decade, provide X-rays with sufficient brilliance that meet spatial and financial requirements affordable in laboratory settings or for university hospitals. In this work, we demonstrate a first proof-of-principle K-edge subtraction imaging experiment using the Munich Compact Light Source (MuCLS), the first user-dedicated installation of a compact synchrotron X-ray source worldwide. It is shown experimentally that the technique of KES increases the visibility of small blood vessels overlaid by bone structures.

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Synchrotron radiation-based coronary angiography

Cited by 6 publications

References 2 publications

Monochromatic X-rays: The future of breast imaging

Monochromatic X-rays: The future of breast imaging

Spectroscopic imaging at compact inverse Compton X-ray sources

K-edge subtraction imaging for coronary angiography with a compact synchrotron X-ray source

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