Synchrotron based planar imaging and digital tomosynthesis of breast and biopsy phantoms using a CMOS active pixel sensor

Szafraniec, Magdalena B.; Konstantinidis, Anastasios; Tromba, Giuliana; Dreossi, Diego; Vecchio, Sara Del; Rigon, Luigi; Sodini, Nicola; Naday, Steve; Gunn, Spencer; McArthur, Alan; Olivo, Alessandro

doi:10.1016/j.ejmp.2014.11.003

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…In addition to 2D and DBT imaging [34], BCT with a monoenergetic, parallel beam from a synchrotron radiation source and the patient in prone position is under investigation at the Elettra facility (Trieste, Italy) [35][36][37][38]. In that experimental project, the patient is placed on a rotating and vertically translating bed with her breast freely hanging from a hole.…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models

et al. 2018

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“…to that of the current custom-made phantom. Moreover, commercially available medical detector and CMOS APS X-ray detector with larger dimensions and advanced characteristics [25], [26], [27], [52] and [53] will be used.…”

Section: Cnrmentioning

confidence: 99%

“…Furthermore, the use of dual energy iodine-based contrast enhanced digital mammography (CEDM) has been evaluated for the improvement in the detection of lesions [23] and [24]. Digital X-ray detectors, based on complementary metal oxide semiconductor (CMOS) active pixel sensors (APS), have been recently introduced in medical imaging applications [25], [26] and [27]. A pixel pitch smaller than 70-100 m  , that is currently available in flat panels, can improve the detection and characterization of Cs  [28].…”

Section: Introductionmentioning

confidence: 99%

Dual energy subtraction method for breast calcification imaging

Koukou

Martini

Fountos

et al. 2017

Nuclear Instruments and Methods in Physics Research Section A:

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The aim of this work was to present an experimental dual energy (DE) method for the visualization of microcalcifications (Cs ). A modified radiographic X-ray tube combined with a high resolution complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) X-ray detector was used. A 40/70 kV spectral combination was filtered with 100 m  cadmium (Cd) and 1000 m  copper (Cu) for the low/highenergy combination. Homogenous and inhomogeneous breast phantoms and two calcification phantoms were constructed with various calcification thicknesses, ranging from 16 to 152 m . Contrast-to-noise ratio (CNR) was calculated from the DE subtracted images for various entrance surface doses. A calcification thickness of 152 m  was visible, with mean glandular doses (MGD) in the acceptable levels (below 3 mGy). Additional post-processing on the DE images of the inhomogeneous breast phantom resulted in a minimum visible calcification thickness of 93 m  (MGD=1.62 mGy). The proposed DE method could potentially improve calcification visibility in DE breast calcification imaging.

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“…In this paper, we draw the reader's attention to biological and medical synchrotron studies, and, within this area, the focus will be even narrower, by including only research involving the distribution and biochemistry of trace elements in human tissues. Synchrotron-based biological and medical research including conventional and phase-contrast X-ray imaging (planar and tomographic modalities) [14][15][16][17][18], protein crystallography and X-ray diffraction (XRD) on cells and tissues [19][20][21], and radiation therapy studies [22][23][24] were excluded. The importance of such investigations for the advancement of both diagnostic and therapeutic modalities employed in clinical practice, cannot be underestimated.…”

Section: Introductionmentioning

confidence: 99%

Probing Trace Elements in Human Tissues with Synchrotron Radiation

Gherase

Fleming

2019

Crystals

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For the past several decades, synchrotron radiation has been extensively used to measure the spatial distribution and chemical affinity of elements found in trace concentrations (<few µg/g) in animal and human tissues. Intense and highly focused (lateral size of several micrometers) X-ray beams combined with small steps of photon energy tuning (2–3 eV) of synchrotron radiation allowed X-ray fluorescence (XRF) and X-ray absorption spectroscopy (XAS) techniques to nondestructively and simultaneously detect trace elements as well as identify their chemical affinity and speciation in situ, respectively. Although limited by measurement time and radiation damage to the tissue, these techniques are commonly used to obtain two-dimensional and three-dimensional maps of several elements at synchrotron facilities around the world. The spatial distribution and chemistry of the trace elements obtained is then correlated to the targeted anatomical structures and to the biological functions (normal or pathological). For example, synchrotron-based in vitro studies of various human tissues showed significant differences between the normal and pathological distributions of metallic trace elements such as iron, zinc, copper, and lead in relation to human diseases ranging from Parkinson’s disease and cancer to osteoporosis and osteoarthritis. Current research effort is aimed at not only measuring the abnormal elemental distributions associated with various diseases, but also indicate or discover possible biological mechanisms that could explain such observations. While a number of studies confirmed and strengthened previous knowledge, others revealed or suggested new possible roles of trace elements or provided a more accurate spatial distribution in relation to the underlying histology. This area of research is at the intersection of several current fundamental and applied scientific inquiries such as metabolomics, medicine, biochemistry, toxicology, food science, health physics, and environmental and public health.

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Synchrotron based planar imaging and digital tomosynthesis of breast and biopsy phantoms using a CMOS active pixel sensor

Cited by 13 publications

References 18 publications

Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models

Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models

Dual energy subtraction method for breast calcification imaging

Probing Trace Elements in Human Tissues with Synchrotron Radiation

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