Synchronously Multiple Gastric Adenocarcinomas with Intestinal Mucin Phenotype in a Patient not Infected with &lt;i&gt;Helicobacter pylori&lt;/i&gt;, Showing a Gastritis-like Appearance

Kishimoto, Kenichi; Shibagaki, Kotaro; Itawaki, Ayako; Tanaka, Shinsaku; Takahashi, Yusuke; Cho, Yumi; Ikuta, Yukihiro; Oshima, Naoki; Nagasaki, Makoto; Ishihara, Shunji

doi:10.2169/internalmedicine.5393-20

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…There was no area suspicious of hard texture in the lesion, and the depth was expected to be intramucosal (Categories 4.2, 4.3, and 4.4 of the revised Vienna classification). 4 There was no Barrett’s mucosa at the EGJ. Magnifying endoscopy with narrow-band imaging (NBI) showed granular and papillary micro-mucosal patterns of unequal size and an enlarged white zone ( Figure 1(d) –( f )).…”

Section: Case Presentationmentioning

confidence: 98%

A rare case of Helicobacter pylori–uninfected foveolar-type gastric cancer with submucosal invasion and lymph node metastasis

Hirano

Nomura

Dan

et al. 2022

SAGE Open Medical Case Reports

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Gastric cancer without Helicobacter pylori infection accounts for less than 1% of all gastric cancers, and is generally considered to be less invasive. This report describes a rare case of H. pylori–uninfected gastric cancer with deep submucosal invasion and lymph node metastasis. Endoscopic submucosal dissection was performed, and pathological examination revealed tubular adenocarcinoma with deep submucosal invasion. We diagnosed foveolar-type gastric adenocarcinoma. While many cases of foveolar-type gastric adenocarcinoma, especially of the white elevated type, are reported as early stage gastric cancer, this case is very rare because it showed submucosal invasion and lymph node metastasis.

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Section: Case Presentationmentioning

confidence: 98%

A rare case of Helicobacter pylori–uninfected foveolar-type gastric cancer with submucosal invasion and lymph node metastasis

Hirano

Nomura

Dan

et al. 2022

SAGE Open Medical Case Reports

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Intestinal-type gastric dysplasia in Helicobacter pylori-naïve patients

et al. 2021

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Gastric dysplastic lesions in Helicobacter pylori‐naïve stomach: Foveolar‐type adenoma and intestinal‐type dysplasia

Shibagaki,

Kushima,

Mishiro

et al. 2024

Pathology International

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Reports of Helicobacter pylori (Hp)‐naïve gastric neoplasm (HpNGN) cases have been rapidly increasing due to the recent increase in the Hp‐naïve population in Japan. Most HpNGNs exhibit the gastric immunophenotype and a low malignant potential regardless of histological type. Especially, foveolar‐type gastric adenoma (FGA) and intestinal‐type gastric dysplasia (IGD) rarely progress to invasive carcinoma. FGA is a foveolar epithelial neoplasm that occurs in the fundic gland (oxyntic gland) mucosa and is classified as the flat type or raspberry type (FGA‐RA). The flat type is a large, whitish flatly elevated lesion while FGA‐RA is a small reddish polyp. Genomically, the flat type is characterized by APC and KRAS gene mutations and FGA‐RA by a common single nucleotide variant in the KLF4 gene. This KLF4 single‐nucleotide variant reportedly induces gastric foveolar epithelial tumorigenesis and activates both cell proliferation and apoptosis, leading to its slow‐growing nature. IGD consists of an intestinalized epithelial dysplasia that develops in the pyloric gland mucosa, characterized as a superficial depressed lesion surrounded by raised mucosa showing a gastritis‐like appearance. Immunohistochemically, it exhibits an intestinal or gastrointestinal phenotype and, frequently, p53 overexpression. Thus, IGD shows unique characteristics in HpNGNs and a potential multistep tumorigenic process.

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Synchronously Multiple Gastric Adenocarcinomas with Intestinal Mucin Phenotype in a Patient not Infected with <i>Helicobacter pylori</i>, Showing a Gastritis-like Appearance

Cited by 4 publications

References 18 publications

A rare case of Helicobacter pylori–uninfected foveolar-type gastric cancer with submucosal invasion and lymph node metastasis

A rare case of Helicobacter pylori–uninfected foveolar-type gastric cancer with submucosal invasion and lymph node metastasis

Intestinal-type gastric dysplasia in Helicobacter pylori-naïve patients

Gastric dysplastic lesions in Helicobacter pylori‐naïve stomach: Foveolar‐type adenoma and intestinal‐type dysplasia

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