Synchronous Seminoma in Abdominopelvic and Inguinal Testes: A Rare Presentation with Unusual Morphology

Abstract

The development of testes occurs in the abdomen during fetal life, after which they migrate into the scrotal sacs during the third trimester. During their descent, they may get arrested anywhere along the tract. Risk of testicular cancer is higher in patients with undescended testes, abdominal testis being more prone than inguinal. Seminoma is the commonest cancer in undescended testis. However, synchronous seminoma involving bilateral cryptorchid testis is rare. Present case is uncommon due to synchronous involvement of abdominopelvic and inguinal testes in extended age. It also exhibited unusual morphology with marked heterogeneity grossly as well as microscopically, instead of a common homogenous appearance.

Intraabdominal mass in adult men with unilateral UDT revealed as seminoma: A case report

“…Testicular cancer is more likely to occur in people who are infertile or sub-fertile. 4 , 5 There is also evidence of a connection between testicular cancer and low birth weight, small for gestational age infants, and hypospadias. The patient in this study had scrotal hypospadias and was infertile.…”

“…In the literature, cases of seminomas in the retroperitoneum, mediastinum, and thymus have been recorded. 5 Neoplastic development of extra-testicular seminoma is thought to occur during the migration of primordial germ cells from the yolk sac endoderm to the scrotum. 3 In our cases the patient presented with retroperitoneal seminoma.…”

“…Seminoma is one of the curable cancers, with cure rates nearing 100% and very high sensitivity with chemotherapy. 5 The patient received 3 and 4 cycles with bleomycin, etoposide, and cisplatin regiment with good response.…”