Synchronous Resection of Colon Adenocarcinoma and Bisegmentectomy of Liver Metastases

Montalvo-Jave, EE; B, Jiménez Bobadilla; M, Espejel Deloiza; Ih, Aguilar Preciado; Lf, Negrete Cervantes; Diliz-Pérez, Héctor Santiago

doi:10.1159/000499423

Cited by 3 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surgical approach of colorectal liver metastases has a lot of controversial points; for example, elderly patients were initially excluded from this possibility. However, liver resections are now routinely performed for patients in their 70s and 80s [ 15 , 16 ]. New surgical techniques, technology, and multidisciplinary teamwork allow surgeons to decide either a synchronous resection, which has shown very good results in selected cases [17] , or a staged resection.…”

Section: Discussionmentioning

confidence: 99%

Right Hepatic and Portal Vein Embolization before Right Hepatectomy for Colorectal Cancer Liver Metastases

Montalvo-Javé¹,

Ayala-Moreno²,

García³

et al. 2023

Case Rep Gastroenterol

View full text Add to dashboard Cite

Colon cancer has had a significant increase in its incidence in recent years. Many of the cases are diagnosed late; it is not unusual that a large number of cases present metastatic disease at the time of diagnosis, and the liver is the main organ where these lesions occur. Surgical approach to this condition has undergone many advances which have allowed a better approach to them. Local techniques such as embolization have gained momentum in recent years and are a great help to the surgical planning. We present the case of a 72-year-old female patient diagnosed with colorectal cancer and metastatic disease. Multiple liver tumors were demonstrated by imaging studies. A staged resection of the primary tumor and the metastatic hepatic tumors was planned. It was decided to perform an embolization of the hepatic artery to cause hypertrophy of the left lobe before the second stage of the surgical approach with good clinical and laboratorial findings after the surgery. Follow-up with adjuvant chemotherapy, imaging studies and tumor markers is planned. Several publications state that surgical approach of metastatic disease is still controversial and that decisions should be made under the context of each patient. Many techniques have shown good results; embolization of the hepatic tumors has a good outcome in the survival rate in selected patients. Hepatic volume and future liver remnant should be always assessed with imaging studies. Each case has to be individualized for the approach of the metastatic disease, always in a coordinated teamwork for maximum benefit of the patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Right Hepatic and Portal Vein Embolization before Right Hepatectomy for Colorectal Cancer Liver Metastases

Montalvo-Javé¹,

Ayala-Moreno²,

García³

et al. 2023

Case Rep Gastroenterol

View full text Add to dashboard Cite

show abstract

“…In this clinical case, an open approach was performed due to the suspicion of perforation of the hollow viscus, and due to the location of both tumors, one on the proximal third of the ascending colon and the other on the splenic flexure, it was decided to perform an extended resection with total colectomy, due to the perforation in one of the tumors, the presence of intestinal material, and contamination of the abdominal cavity, it was decided to perform terminal ileostomy. The incidence of liver metastases in synchronous colon cancer is 11.8%; the possibility of performing resection of synchronous tumors and liver metastases has been described to improve the prognosis of the patients; however, in this clinical case, liver metastases were considered unresectable due to their location, depth, and abscesses presence [15, 20, 21].…”

Section: Discussionmentioning

confidence: 99%

Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor

González

Villaseñor²,

Cruz

et al. 2022

Case Rep Gastroenterol

View full text Add to dashboard Cite

Colorectal cancer is one of the most common malignant neoplasms worldwide. Overall mortality is 33%. Synchronous colorectal cancer refers to more than one malignant tumor detected in different segments of the colon, simultaneously or within 6 months of initial diagnosis. The development of colorectal cancer is a multistep process that originates with a genetic mutation leading to a malignant phenotype and generating a growth advantage. Colorectal cancer presents up to 16% of hypermutations, of which 75% are characterized by microsatellite instability which in turn leads to poorer cell differentiation. Patients with synchronous tumors appear to have a higher proportion of microsatellite instability than patients with single tumors. The clinical case of a 35-year-old man with a perforated left colon tumor and a locally advanced synchronous tumor of the right colon and signs of acute abdomen is presented. The treatment should be based on the location of the synchronous tumors, stage at the time of approach, and the patient’s condition. However, when faced with a complication secondary to colonic cancer, adhering to the principles of oncological surgery can be overcome by the nature of the emergency.

show abstract

“…Surgical treatment for liver and pulmonary metastases in selected mCRC patients may improve survival and prognosis. The five-year survival for mCRC patients with liver metastases who underwent surgical treatment reaches 58%, whereas the survival rate for mCRC patients with liver metastasis without surgical treatment ranges 20-24 months [18,19]. Pulmonary resection for metastases from CRC may improve survival in selected patients.…”

Section: Discussionmentioning

confidence: 99%

Can multidisciplinary approach win the battle against metastatic rectal cancer?

et al. 2021

View full text Add to dashboard Cite

Introduction. Colorectal cancer is the third most common cancer and one of the leading causes of cancer-related deaths in men and women worldwide. The contemporary multidisciplinary approach has decreased rates of local recurrence and improved outcomes in metastatic colorectal cancer. We present a case of a primarily metastatic rectal cancer patient who underwent multidisciplinary planned treatment and showed complete response with now three years disease-free survival. Case outline. A 61-year-old female was diagnosed with a T4N2M1a rectal adenocarcinoma at the age of 58. She underwent six cycles of systemic chemotherapy capecitabine-oxaliplatin plus bevacizumab with partial response confirmed by diagnostic imaging procedures. According to multidisciplinary board decision, preoperative radiotherapy treatment was administered with concomitant Capecitabine-based chemotherapy. A 50.4 Gy total dose was delivered with 1.8 Gy fraction dose. After concomitant chemoradiotherapy treatment, two more cycles of systemic chemotherapy Capecitabine-Oxaliplatin plus Bevacizumab were administered. One month after completion of systemic chemotherapy, primary rectal cancer was operated with a complete response on histopathologic specimens. Six weeks following previous surgery, metastasectomy of lung deposits was performed; histopathology confirmed metastatic adenocarcinoma of colorectal origin. Three more cycles of postoperative chemotherapy capecitabine-oxaliplatin plus bevacizumab were administered. Conclusion. On regular follow-up, no evidence of disease was shown, with disease-free survival of three years. The treatment improved the patient?s quality of life.

show abstract

Synchronous Resection of Colon Adenocarcinoma and Bisegmentectomy of Liver Metastases

Cited by 3 publications

References 6 publications

Right Hepatic and Portal Vein Embolization before Right Hepatectomy for Colorectal Cancer Liver Metastases

Right Hepatic and Portal Vein Embolization before Right Hepatectomy for Colorectal Cancer Liver Metastases

Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor

Can multidisciplinary approach win the battle against metastatic rectal cancer?

Contact Info

Product

Resources

About