Synchronous multicentric desmoid tumors (aggressive fibromatosis) of the extremities

Sundaram, Murali; Duffrin, Henry; McGuire, Michael H.; Vas, Wenzel

doi:10.1007/bf00361449

Cited by 63 publications

(22 citation statements)

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“…For now, an estimation of the growth potential of a desmoid tumor can be obtained only from T2-weighted magnetic resonance images showing increased cellularity. [14][15][16][17][18][19][20][21][22][23][24][25] The role of 2[ 18 F] fluoro-2-deoxy-D-glucose positron emission tomograpy [18FDG-PET] scans to assess the growth potential of DTs and to predict their clinical course based on their metabolic activity is a possibility that has not been examined and may offer a noninvasive means of stratifying the behavior of these tumors.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric Desmoid Tumors in Singapore Familial Adenomatous Polyposis Patients: Clinical Course and Genetic Profile in a Predominantly Chinese Population

Koh¹,

Loi²,

Cao³

et al. 2007

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Mesenteric Desmoid Tumors in Singapore Familial Adenomatous Polyposis Patients: Clinical Course and Genetic Profile in a Predominantly Chinese Population

Koh¹,

Loi²,

Cao³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…However, it has been accurate in predicting the histological nature of a mass only in patients with lipomas, lipoma-like liposarcomas, hematomas, hemangiomas, aggressive fibromatosis, and pigmented villonodular synovitis [6][7][8][9]. We believe that myxoid liposarcomas may be added to this list.…”

Section: Discussionmentioning

confidence: 99%

Myxoid liposarcoma: magnetic resonance imaging appearances with clinical and histological correlation

et al. 1990

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Myxoid liposarcoma is the most common type of liposarcoma. The magnetic resonance imaging (MRI) features of this tumor were evaluated and correlated with its clinical and histological features in seven patients to determine under what circumstances the tumor should be considered in differential diagnosis and why its signal intensity differs from those of lipoma and lipoma-like (lipoblastic) liposarcoma. In all patients the tumor presented in a lower extremity (5 thigh, 2 calf) as a painless, slowly growing mass which had been present for several months to several years. MRI examination revealed the tumors to be encapsulated, noninfiltrating, and usually septated. On T1-weighted sequences five of seven lesions (71%) showed lacy, amorphous, or linear foci of high signal within a low signal mass. These foci are believed to represent fat within the tumor and distinguish it from several other benign and malignant masses. If an indolent mass in a lower extremity demonstrates a predominantly low signal with a few amorphous or linear high signal foci on T1-weighted sequences, one should consider the possibility of myxoid liposarcoma even if it appears benign by all other criteria. Histologic evaluation showed that myxoid liposarcomas contain less than 10% mature fat, which accounts for their low signal on T1-weighted sequences in contrast to the high signal of lipomas and lipoblastic liposarcomas.

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“…There have also been reports of patients with local multicentric tumors present at diagnosis. These include a patient with masses on the right thigh and buttock (26), and another with masses in the left hip and popliteal fossa (27). In these cases, microscopic contiguous invasion of the initial lesion probably led to the formation of the second focus.…”

Section: Discussionmentioning

confidence: 99%

Contralateral recurrence of aggressive fibromatosis in a young woman: A case report and review of the literature

2015

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Abstract. Aggressive fibromatosis (AF) is a benign non-encapsulated tumor of mesenchymal origin, with a tendency for local spread along fascial planes. Local invasion can lead to extensive morbidity and even mortality due to destruction of the bones, organs and soft tissues. This rare lesion is observed 1,000 times more frequently in patients with familial adenomatous polyposis or Gardner's syndrome due to the inheritance of the adenomatous polyposis coli (APC) gene. While AF does not metastasize, local recurrence is common. Distant recurrence is extremely rare, but is observed in those with a germ line APC mutation. The present study details the case of a 20-year-old woman with a melanoma of the right shoulder, treated definitively with surgery. The patient then developed a painful mass at the surgical site; a surgical biopsy demonstrated that the mass was AF. The patient was treated with surgical resection, radiation therapy, and a course of tamoxifen. Five years later, the patient presented with left forearm pain and diminished range of motion due to an infiltrating mass. This was excised and a clinical diagnosis of recurrent AF was made, in this patient lacking familial predisposition to the disease.

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Synchronous multicentric desmoid tumors (aggressive fibromatosis) of the extremities

Cited by 63 publications

References 5 publications

Mesenteric Desmoid Tumors in Singapore Familial Adenomatous Polyposis Patients: Clinical Course and Genetic Profile in a Predominantly Chinese Population

Mesenteric Desmoid Tumors in Singapore Familial Adenomatous Polyposis Patients: Clinical Course and Genetic Profile in a Predominantly Chinese Population

Myxoid liposarcoma: magnetic resonance imaging appearances with clinical and histological correlation

Contralateral recurrence of aggressive fibromatosis in a young woman: A case report and review of the literature

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