Synchronous mucinous adenocarcinoma of the recto sigmoid revealed by and seeding an anal fistula. (A case report and review of the literature)

Spiridakis, Konstadinos G.; Sfakianakis, Elefterios; Flamourakis, Matthaios; Intzepogazoglou, D S; Tsagataki, Eleni S.; Ximeris, Nikolaos E.; Rachmanis, Efstathios K.; Gionis, Ioannis; Kostakis, G.; Christodoulakis, Manousos

doi:10.1016/j.ijscr.2017.06.001

Cited by 3 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sixty-two patients from 37 studies were finally included in the systematic review ( 8 , 11 – 46 ). Clinical data from these articles were pooled with the 8 cases from our institution.…”

Section: Resultsmentioning

confidence: 99%

Adjuvant chemoradiotherapy does not improve outcomes in patients with fistula-associated anal adenocarcinoma undergoing abdominoperineal resection

Wang

Wang²,

Zhang³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveAbdominoperineal resection (APR) is currently established as a standard treatment regimen for fistula-associated anal adenocarcinoma (FAAA), however, the efficacy of chemoradiotherapy (CRT) remains unclear. The aim of this study is to evaluate the role of CRT in patients with FAAA treated with APR through single-center experience and literature review.MethodsA retrospective review was performed on patients with FAAA consecutive treated in our institution from 2005 to 2022. In addition, a systematic literature search was performed using PubMed and MEDLINE. All patients with FAAA who received APR in our institution and reported in the literature were included and divided into three categories for statistical analysis: APR alone (APR group), neoadjuvant therapy combined APR (CRT+APR group), and APR combined postoperative therapy (APR+CRT group).ResultsFifteen patients with FAAA were identified from our retrospective charts review. At a median follow-up time of 18 months, the recurrence-free survival rate was 53.3% and the survival rate was 73.3%. Eight patients underwent APR and 6 received postoperative chemotherapy. Among them, one died, one developed recurrence and the remaining six patients were alive with disease free. We found 37 publications describing 62 patients with FAAA treated with APR. Clinical data from these articles were analyzed together with the 8 cases in our institution. The overall survival rates were 94.1%, 70.8%, and 38.5% at 1-, 3-, 5-years respectively. Combining (neo)adjuvant therapy did not appear to improve outcomes in FAAA treated with APR (CRT+APR vs. APR, p=0.977; APR+CRT vs. APR, p=0.351). Lymph node involvement was shown to be significantly associated with poor outcomes by multivariate analysis (p=0.020).ConclusionsFor patients with FAAA without lymph node involvement, APR is adequate to control disease and the addition of CRT does not appear to prolong survival.

show abstract

“…Sixty-two patients from 37 studies were finally included in the systematic review ( 8 , 11 – 46 ). Clinical data from these articles were pooled with the 8 cases from our institution.…”

Section: Resultsmentioning

confidence: 99%

Adjuvant chemoradiotherapy does not improve outcomes in patients with fistula-associated anal adenocarcinoma undergoing abdominoperineal resection

Wang

Wang²,

Zhang³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…An anal fistula that is persistent and recurrent causes inflammation that can lead to primary cancer, in 0,1% of all anal fistulae cancer will develop (1,2) . This case emphasizes the importance of further investigation of recurrent perianal abscesses and the need for biopsy of anal fistula (3) .…”

Section: Introductionmentioning

confidence: 81%

“…A histological examination should be performed in all cases of long standing fistula and perianal abscess (3)(4)(5) . In 1907 Charles Ryall (5) was the first to report the phenomenon known as cancer infection which is implantation metastasis of solid cancers (3,6) . In our case, perianal disease was attributed as the cause of the patient's symptoms and the primary carcinoma was missed.…”

Section: Discussionmentioning

confidence: 99%

Rectosigmoid Adenocarcinoma That Is Synchronous with an Anal Fistula : Case Report in Saudi Arabia

AlYousef

Hakami

Wtayyan

et al. 2018

Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Rectosigmoid mucinous adenocarcinoma that is Synchronous with an anal fistula is a very rare condition thus its diagnosis and management are challenging. Here, we showed the diagnosis and management of a single case for a 57-year-old Saudi male presented with low rectal mass and gluteal abscess and a history of recurrent perianal abscesses that was managed as benign tumor and without a family history of neoplasms of re colorectal parts. After reviewing the literature concerning the aetiopathogenesis of this case and the suggested treatment. The clinical examination showed a perianal fistula and a digital rectal examination was conducted after incision and drainage of the right gluteal abscess then rigid sigmoidoscopy was performed and biopsy was collected showing invasive moderately differentiated adenocarcinoma. The decision was to avoid radiation preoperative due to abscess and extensive perianal disease and a treatment plan was initiated and the patient was followed up with regular CT examination.

show abstract

“…Today, the main and most accepted theory refers to the malignant degeneration of chronic inflammatory perianal fistulas (primary) [ 8 ]. However, another theory links the origin of this tumor with the seeding of premalignant cells originated in the adjacent colon (secondary) into the fistula tract [ 9 , 10 ]. Association with benign chronic inflammatory processes is common, such as perianal fistulas or abscesses and Crohn’s disease.…”

Section: Discussionmentioning

confidence: 99%

Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report

Feo

Veneroni

Santoru

et al. 2021

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

Highlights Mucinous adenocarcinoma of the perianal region is extremely rare (6.9% of anal neoplasms and 2–3% of all gastrointestinal malignancies). Given the low incidence of this tumor, it is often missed at initial evaluation. Association with chronic perianal fistula are common and inflammatory symptoms can be misleading with delay in diagnosis. The paucity of publications leads to a lack of consensus on both diagnostic and therapeutic approaches. The understanding of the etiopathogenic mechanisms may lead to the development of novel diagnostic and therapeutic protocols.

show abstract

Synchronous mucinous adenocarcinoma of the recto sigmoid revealed by and seeding an anal fistula. (A case report and review of the literature)

Cited by 3 publications

References 21 publications

Adjuvant chemoradiotherapy does not improve outcomes in patients with fistula-associated anal adenocarcinoma undergoing abdominoperineal resection

Adjuvant chemoradiotherapy does not improve outcomes in patients with fistula-associated anal adenocarcinoma undergoing abdominoperineal resection

Rectosigmoid Adenocarcinoma That Is Synchronous with an Anal Fistula : Case Report in Saudi Arabia

Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report

Contact Info

Product

Resources

About