Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: Case report of an unusual event

Santos, Harim-Tavares dos; Benevenuto, Bruno-Augusto; Filho, Edson-Robles-Castilla; Altemani, Albina

doi:10.4317/jced.52643

Cited by 5 publications

(19 citation statements)

References 18 publications

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“…On thorough review, all these cases involved male patients who ranged from 44 to 83 years of age [1]. Another case report, written seven years prior, stated that there have only been 11 reported cases of cutaneous SCC metastatic to tissues involving CLL/SLL.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that the mechanism underlying the development of synchronous malignancies may be the result of cancer-to-cancer metastasis which is influenced by nonmodifiable factors such as age and genetic susceptibility or modifiable factors such as exposure to carcinogenic agents via environment or lifestyle habits. Furthermore, cancer-tocancer metastasis can be investigated by using specific immunohistochemical profiles [1]. Although many theories have been postulated, the exact mechanism has yet to be established.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism for which chronic lymphocytic leukemia leads to impaired flow through the coronary arteries is proposed as different compared to that of an atherosclerotic plaque or thrombus. Tumor encases the coronary arteries causing external compression of the vessel, whereas atherosclerotic plaque or thrombus precipitates occlusion within the vessel [1]. This was demonstrated on autopsy in which malignant cells extended into the tunica adventitia and tunica media.…”

Section: Discussionmentioning

confidence: 99%

“…Synchronous tumors are rare. Patients who present with CLL/SLL associated with an aggressive metastatic SCC are more vulnerable to malignant spread, recurrence, and death as compared to individuals without an associated secondary malignancy [1]. It is known that cancer cells impact the coagulation cascade leading to a hypercoagulable state, thrombus formation and propagation, and anemia which can lead to venous thromboembolism.…”

Section: Introductionmentioning

confidence: 99%

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Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction

Bernshteyn

Smith-Hannah

Dhamoon

2020

Case Reports in Oncological Medicine

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A 66-year-old woman presented to the hospital with a one-month history of shortness of breath, fatigue, and postmenopausal vaginal bleeding and a one-week history of chest pain. This case report discusses the rare synchronous occurrence of two different malignancies in the setting of non-ST segment elevation myocardial infarction and the relation between these unfortunate events. Besides the case presented in this report, there have been only 13 reported cases of synchronous chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) associated with metastatic squamous cell carcinoma. While it is well known that malignancy causes a hypercoagulable state, there are other mechanisms which may have contributed to the patient's myocardial ischemia including external vascular compression, tumor lysis syndrome, and anemia. This case report discusses the rarity of synchronous malignancies but the importance of understanding and consideration of cardiac events in this population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction

Bernshteyn

Smith-Hannah

Dhamoon

2020

Case Reports in Oncological Medicine

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“…Swelling of the cervical lymph nodes may indicate lymphadenitis 5) , malignant lymphoma 15) , or lymph node metastasis 4) . In cases where the nodes are larger than 10 mm on postoperative computed tomography (CT) images of a malignant tumor, metastasis can be assumed.…”

Section: Introductionmentioning

confidence: 99%

Carcinoma of Maxillary Gingiva with Non-specific Cervical Lymph Node Swelling

Matsushima

Shigematsu

Ohata

et al. 2017

Bull. Tokyo Dent. Coll.

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Swelling of the cervical lymph nodes may indicate lymphadenitis, malignant lymphoma, or metastasis. Lymph nodes larger than 10 mm on computed tomography (CT) are strongly indicative of postoperative metastasis from carcinoma. Here, we report a case of large, inflamed lymph nodes mimicking metastasis. The patient was a 76-year-old woman who experienced discomfort in the left-side maxillary gingiva commencing in August 2011. By September, the area had become painful, causing her to visit the Tokyo Dental College Chiba Hospital, at which time a 75×50-mm swollen ulcer was observed in the maxillary gingiva on the left side. A CT image revealed a neoplastic lesion between the alveolar bone on the left side of the maxilla and the base of the maxillary sinus, together with evidence of osteoclastic activity. The bilateral cervical lymph nodes were Level II and had a uniform interior of approximately 5 mm. The lesion was subsequently excised under general anesthesia. At 34 days postoperatively, CT imaging revealed bilateral 40-mm internal heterogeneous lymphadenopathy at Level II. No inflammation of the maxillary gingiva was observed, however, and blood tests revealed no inflammatory findings. Bilateral cervical lymph node metastasis was diagnosed based on CT and oral cavity observation. Radical neck dissection of left cervical region was performed under general anesthesia. Histopathological examination of the lymph nodes revealed no metastasis at Levels I-V, however. The reason for this increase in lymph node size is discussed.

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Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

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Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: Case report of an unusual event

Cited by 5 publications

References 18 publications

Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction

Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction

Carcinoma of Maxillary Gingiva with Non-specific Cervical Lymph Node Swelling

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

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