Abstract:Extrapulmonary neuroendocrine carcinoma is uncommon. Cases of primary neuroendocrine carcinoma of the breast have been reported, though rare. We report the case of a 53-year-old woman who underwent a mastectomy for breast carcinoma and presented three years later with synchronous masses in the head of the pancreas and liver. Fine-needle aspiration of both organs revealed a neuroendocrine carcinoma. The original breast tumor was reviewed and found to express neuroendocrine markers. A diagnosis of a primary neur… Show more
Metastatic lesions of the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. Many tumours involve the pancreas secondarily and may manifest with different clinical and imaging characteristics. Although many patients have widespread disease, isolated metastases can be found. Surgical management is associated with improved survival in these cases. The experience of the pancreatic surgery unit and imaging department of our hospital in many patients presenting with pancreatic metastases is presented, and a review of the recent literature is undertaken. Main Messages• The early recognition of secondary pancreatic tumours on US, CT and MRI is extremely important.• Pancreatic metastases may mimic primary pancreatic adenocarcinoma or induce acute pancreatitis.• Most pancreatic metastases are discovered on a CT examination performed for follow-up.
Metastatic lesions of the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. Many tumours involve the pancreas secondarily and may manifest with different clinical and imaging characteristics. Although many patients have widespread disease, isolated metastases can be found. Surgical management is associated with improved survival in these cases. The experience of the pancreatic surgery unit and imaging department of our hospital in many patients presenting with pancreatic metastases is presented, and a review of the recent literature is undertaken. Main Messages• The early recognition of secondary pancreatic tumours on US, CT and MRI is extremely important.• Pancreatic metastases may mimic primary pancreatic adenocarcinoma or induce acute pancreatitis.• Most pancreatic metastases are discovered on a CT examination performed for follow-up.
“…Par ailleurs, la certitude de l'origine mammaire primitive de ces tumeurs repose essentiellement sur la présence d'une composante carcinomateuse intracanalaire. L'expression de récepteurs hormonaux par les cellules tumorales conforte également le diagnostic [18,19]. Dans notre série, l'origine mammaire était retenue après avoir éliminé une métastase tumorale d'autres sites par un bilan d'extension ; de même, les tumeurs exprimaient les récepteurs hormonaux dans 62 % des cas.…”
Section: éTude Clinique Et Diagnostic Positifunclassified
“…The histological differentiation grade is the most significant prognostic factor. oestrogen and progesterone receptor positivity and mucinosis differentiation are characteristics which favour a better prognosis 21. According to a study, patients with neuroendocrine carcinoma of the breast have a graver prognosis in the form of shorter overall survival and disease-specific survival when compared with the invasive breast carcinoma NOS in identical stages 7.…”
Primary neuroendocrine carcinoma of breast is a very rare malignancy and preoperative diagnosis is difficult by clinical examination alone.Most oftenly, histopathological examination (HPE) and immunohistochemistry (IHC) studies are required to establish the diagnosis. We describe here a case of a primary neuroendocrine carcinoma of right breast in a 32-year-old woman. The patient underwent a right modified radical mastectomy, and the diagnosis was conclusively established postoperatively by the HPE and IHC reports. The IHC report revealed positive status of oestrogen, progesterone and Herceptin receptors.
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