Synchronous mantle cell lymph node lymphoma and pulmonary adenocarcinoma: a case report with literature review

Braham, Emna; Zarrouk, M.; Mlika, Mona; Kilani, T.; Mezni, Faouzi El

doi:10.1111/crj.12352

Cited by 9 publications

(11 citation statements)

References 11 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coexistence of adenocarcinoma and mantle cell lymph node lymphoma in other anatomical sites, such as lung, has been reported in literature. Braham et al 13 presented the first case of primary lung adenocarcinoma associated to lymph node MCL. This lymphoma is usually synchronously present with plasma cell dyscrasia or granulomatous diseases such as sarcoidosis 14,15 .…”

Section: Discussionmentioning

confidence: 99%

What can hide an enlarged lymph node of a patient with prostatic adenocarcinoma?

et al. 2023

View full text Add to dashboard Cite

Introduction. Adenocarcinoma is the most common prostatic malignancy where clinical management, Gleason score and recent updates in prostate cancer staging play critical role. Mantle cell lymphoma originates from malignant transformation of B lymphocyte in the outer edge of lymph node follicle, with pathognomonic overexpression of cyclin D1. We present a rare case of two neoplasms occurred in the same individual person. Case report. In a 68-year-old patient planned for radical prostatectomy during the hospital preoperative examinations using multislice computed tomography tumor mass confined to the prostate but also excessive lymph node enlargement were revealed. Tissue specimens were analyzed after using hematoxylin and eosin staining, as well as immunohistochemical biomarker panel. Having performed a thorough histological examination, a diagnosis of prostatic adenocarcinoma, Gleason score 3+4=7, ISUP GG2, was given. Microscopic analysis of lymph node involvement showed unexpected, diffuse proliferation of small lymphoid cells, with irregular nuclei, wide mantle zone and hyalinized blood vessels. After using immunohistochemical staining for specific markers, another diagnosis was set, and it was non Hodgkin mantle cell lymphoma. Conclusion. A prostatic adenocarcinoma can extremely rarely be in a coexistence with undiagnosed lymphoproliferative disease, such as non Hodgkin mantle cell lymphoma in our case.

show abstract

Section: Discussionmentioning

confidence: 99%

What can hide an enlarged lymph node of a patient with prostatic adenocarcinoma?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…[275,276] One of the most accepted theories about the synergy between one neoplasm and another is the secondary chronic inflammatory process that solid neoplasms generate can trigger lymphoma. [35,90] Chronic inflammatory processes such as infections (H. Pylori, Epstein-Barr, HIV, and hepatitis C) or autoimmune diseases (chronic thyroiditis, Sjogren's syndrome, celiac disease, and rheumatoid arthritis) are known to be associated with the development of B-cell lymphoma, mainly MALT type lymphoma. [277,278] The mechanisms for this lymphoid transformation are not clear.…”

Section: Discussionmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

View full text Add to dashboard Cite

Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

show abstract

“…In the literature, a total of 6 cases with synchronous MCL and lung carcinoma were reported, and all of them received chemotherapy (18,(32)(33)(34)(35)(36) (Table II). Specifically, Kampalath et al (18) reported that a rare case of synchronous MCLBMI and ES-SCLC was treated with cisplatin, etoposide and rituximab, and remained in complete remission for ~2.5 years following the initial diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Synchronous mantle cell lymphoma bone marrow involvement complicated with extensive‑stage small cell lung cancer: A case report and literature review

Fan

Liu

et al. 2022

Oncol Lett

View full text Add to dashboard Cite

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma with an advanced stage; it occurs frequently and affects the lymph nodes, spleen, blood and bone marrow. The synchronous occurrence of MCL bone marrow involvement (MCLBMI) and malignant tumors is extremely rare. To the best of our knowledge, synchronous extensive-stage small cell lung cancer (ES-SCLC) and MCLBMI have not been previously reported. In the present study, a rare case of ES-SCLC with synchronous MCLBMI is reported in a 59-year-old man. The patient received cisplatin, etoposide, dexamethasone and rituximab chemotherapy for the treatment of both malignancies. The follow-up computed tomography scan disclosed regression of the left upper lobe mass and the routine blood test indicated that the platelet count was gradually increasing to normal levels. Following therapy, the patient achieved a partial response. The experience in this case report indicated that the treatment of synchronous SCLC and MCLBMI requires consideration of the respective patient clinical features, biological behavior and cumulative toxicity of the treatment regimens administered for both malignant tumors. The present study demonstrated that thrombocytopenia was not a chemotherapy contraindication, thus providing a new treatment option for this type of patient.

show abstract

Synchronous mantle cell lymph node lymphoma and pulmonary adenocarcinoma: a case report with literature review

Abstract: Progresses are necessary to understand the pathogenesis of of synchronous occurrence of both diseases.

Cited by 9 publications

References 11 publications

What can hide an enlarged lymph node of a patient with prostatic adenocarcinoma?

What can hide an enlarged lymph node of a patient with prostatic adenocarcinoma?

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous mantle cell lymphoma bone marrow involvement complicated with extensive‑stage small cell lung cancer: A case report and literature review

Contact Info

Product

Resources

About